ID   A0A074VI76_9PEZI        Unreviewed;       322 AA.
AC   A0A074VI76;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Di-copper centre-containing protein {ECO:0000313|EMBL:KEQ60213.1};
GN   ORFNames=M437DRAFT_87047 {ECO:0000313|EMBL:KEQ60213.1};
OS   Aureobasidium melanogenum CBS 110374.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Dothideomycetidae; Dothideales; Saccotheciaceae; Aureobasidium.
OX   NCBI_TaxID=1043003 {ECO:0000313|EMBL:KEQ60213.1, ECO:0000313|Proteomes:UP000030672};
RN   [1] {ECO:0000313|EMBL:KEQ60213.1, ECO:0000313|Proteomes:UP000030672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 110374 {ECO:0000313|EMBL:KEQ60213.1,
RC   ECO:0000313|Proteomes:UP000030672};
RX   PubMed=24984952;
RA   Gostin Ar C., Ohm R.A., Kogej T., Sonjak S., Turk M., Zajc J., Zalar P.,
RA   Grube M., Sun H., Han J., Sharma A., Chiniquy J., Ngan C.Y., Lipzen A.,
RA   Barry K., Grigoriev I.V., Gunde-Cimerman N.;
RT   "Genome sequencing of four Aureobasidium pullulans varieties:
RT   biotechnological potential, stress tolerance, and description of new
RT   species.";
RL   BMC Genomics 15:549-549(2014).
CC   -!- COFACTOR:
CC       Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC         Evidence={ECO:0000256|ARBA:ARBA00001973};
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DR   EMBL; KL584844; KEQ60213.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A074VI76; -.
DR   STRING; 1043003.A0A074VI76; -.
DR   HOGENOM; CLU_865946_0_0_1; -.
DR   OrthoDB; 4070889at2759; -.
DR   Proteomes; UP000030672; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 2.
DR   InterPro; IPR008922; Di-copper_centre_dom_sf.
DR   InterPro; IPR002227; Tyrosinase_Cu-bd.
DR   PANTHER; PTHR11474:SF124; TYROSINASE; 1.
DR   PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR   Pfam; PF00264; Tyrosinase; 1.
DR   SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
PE   4: Predicted;
KW   Copper {ECO:0000256|ARBA:ARBA00023008}; Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030672};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        41..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          151..201
FT                   /note="Tyrosinase copper-binding"
FT                   /evidence="ECO:0000259|Pfam:PF00264"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..32
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   322 AA;  36288 MW;  A8B99A1EDFCC308F CRC64;
     MSQQTILSEK QQLAQELEKK QPQNNDLESQ SPGSPPPARP VFLLLWLLFV LGTVATIVSS
     NWSKPDCLNK AQHILHKSTN PVTTSTSLPK SAPTSTCDNL TLRREWRSMK PLEQARYRSA
     VRCLLDLPSK NDNTGNRLGD FLSAYSVSGW HATQTSDYLP WNRFFMHSLE SALRNECAYR
     GDMPYLDWTV AAAYPESLGE PASATTASPQ AAFHDKLTKQ HLDPALVSEI MSAGTYDDFA
     HVLEARITSL APFDLSSPEL PQDPLFLHQL QVDRLWWLWQ QQHPKAEMLV EDERVRLHGF
     GNSIAVKSVA STEGYDLCYR YV
//