ID A0A074VQF1_9PEZI Unreviewed; 996 AA.
AC A0A074VQF1;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 08-NOV-2023, entry version 33.
DE RecName: Full=Transcription elongation factor SPT5 {ECO:0000256|ARBA:ARBA00020181, ECO:0000256|PIRNR:PIRNR036945};
GN ORFNames=M437DRAFT_52118 {ECO:0000313|EMBL:KEQ61394.1};
OS Aureobasidium melanogenum CBS 110374.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Dothideales; Saccotheciaceae; Aureobasidium.
OX NCBI_TaxID=1043003 {ECO:0000313|EMBL:KEQ61394.1, ECO:0000313|Proteomes:UP000030672};
RN [1] {ECO:0000313|EMBL:KEQ61394.1, ECO:0000313|Proteomes:UP000030672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 110374 {ECO:0000313|EMBL:KEQ61394.1,
RC ECO:0000313|Proteomes:UP000030672};
RX PubMed=24984952;
RA Gostin Ar C., Ohm R.A., Kogej T., Sonjak S., Turk M., Zajc J., Zalar P.,
RA Grube M., Sun H., Han J., Sharma A., Chiniquy J., Ngan C.Y., Lipzen A.,
RA Barry K., Grigoriev I.V., Gunde-Cimerman N.;
RT "Genome sequencing of four Aureobasidium pullulans varieties:
RT biotechnological potential, stress tolerance, and description of new
RT species.";
RL BMC Genomics 15:549-549(2014).
CC -!- FUNCTION: The SPT4-SPT5 complex mediates both activation and inhibition
CC of transcription elongation, and plays a role in pre-mRNA processing.
CC This complex seems to be important for the stability of the RNA
CC polymerase II elongation machinery on the chromatin template but not
CC for the inherent ability of this machinery to translocate down the
CC gene. {ECO:0000256|ARBA:ARBA00024691, ECO:0000256|PIRNR:PIRNR036945}.
CC -!- SUBUNIT: Component of the SPT4-SPT5 complex. Interacts with RNA
CC polymerase II. {ECO:0000256|ARBA:ARBA00025870}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR036945}.
CC -!- SIMILARITY: Belongs to the SPT5 family. {ECO:0000256|ARBA:ARBA00006956,
CC ECO:0000256|PIRNR:PIRNR036945}.
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DR EMBL; KL584838; KEQ61394.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A074VQF1; -.
DR STRING; 1043003.A0A074VQF1; -.
DR HOGENOM; CLU_003537_1_1_1; -.
DR OrthoDB; 24955at2759; -.
DR Proteomes; UP000030672; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006354; P:DNA-templated transcription elongation; IEA:InterPro.
DR GO; GO:0032784; P:regulation of DNA-templated transcription elongation; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd06081; KOW_Spt5_1; 1.
DR CDD; cd06082; KOW_Spt5_2; 1.
DR CDD; cd06083; KOW_Spt5_3; 1.
DR CDD; cd06084; KOW_Spt5_4; 1.
DR CDD; cd06085; KOW_Spt5_5; 1.
DR CDD; cd09888; NGN_Euk; 1.
DR Gene3D; 2.30.30.30; -; 3.
DR Gene3D; 3.30.70.940; NusG, N-terminal domain; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR041973; KOW_Spt5_1.
DR InterPro; IPR041975; KOW_Spt5_2.
DR InterPro; IPR041976; KOW_Spt5_3.
DR InterPro; IPR041977; KOW_Spt5_4.
DR InterPro; IPR041978; KOW_Spt5_5.
DR InterPro; IPR005100; NGN-domain.
DR InterPro; IPR036735; NGN_dom_sf.
DR InterPro; IPR039385; NGN_Euk.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR039659; SPT5.
DR InterPro; IPR022581; Spt5_N.
DR InterPro; IPR017071; TF_Spt5_eukaryote.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR11125; SUPPRESSOR OF TY 5; 1.
DR PANTHER; PTHR11125:SF7; TRANSCRIPTION ELONGATION FACTOR SPT5; 1.
DR Pfam; PF03439; Spt5-NGN; 1.
DR Pfam; PF11942; Spt5_N; 1.
DR PIRSF; PIRSF036945; Spt5; 1.
DR SMART; SM00739; KOW; 5.
DR SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
PE 3: Inferred from homology;
KW Elongation factor {ECO:0000313|EMBL:KEQ61394.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR036945};
KW Protein biosynthesis {ECO:0000313|EMBL:KEQ61394.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030672};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR036945}.
FT DOMAIN 306..333
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 466..493
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 519..547
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 642..667
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 736..763
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT REGION 1..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 360..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 796..851
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 919..996
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..48
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..78
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..99
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..142
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 996 AA; 107536 MW; 158F41551E8BDC8D CRC64;
MSFLNQDFGD ASDDEEEFNP APAVASDDEA DNNDDNDQGQ DDNQDDDDDA QPNARRSSAQ
ADDQDDDDAP SRRRANNDDD DEEEDDEDEE DDEEDEEDED IGHPRKRRRK GPRNQFLDVE
AEVDDEDEEE PDEDDEIAGE EMHPDDLLEL PAGAERDDRK HRELDRQRDL AASMDAEKQA
QALKERYGRN RAANVDSAVV PQRLLLPSVD DPKIWRLKCK PGKEREVVFA IMKRIEDRAG
TREPLQLISA FERGGVMAGN LYCEALVVEH VTNALEGLQN VYMGTKPMMV PITEMPDLLR
TRKSKSLEPG MYVRVKRGKY AGDLAQIDEV ESNGTEVTLR LIPRLDYGLN EDINAAVDSK
RKRGGFGANT GPRPPQRLFS ENEARKRHGR YLTKGTGFTA NTWTYMNDTY VDGFLIKDYK
ANHLQSEDVN PTLEEVTKFA ADAEDGTENL DLSALAATIK SNSSGAFLPG DHVEIWQGEQ
RGVVGKAVSV HSDIVRILVS SGELSGQIIE SPVKGLRKLF REGDHVKVIG GSKYFDEVGM
VVKIVEDRVT ILTDSNQTEI TVFSKDLRVA TDSGGQVGVG KYDLHELVQL DASTVACVIK
VDRESLRVLD QTGTVRSLLP SNISNKLERR KNAVATDREG SEIHIDDTVK EEGGEGRQGR
VLHIHRNFLF AHNREQTDNA GVFVVRTNNV KTVAAKGGRV ASAQAGLMKM NPALQRPGAQ
QAGAQAMPPP RQMGRDRLIG KTCTIRRGPH KGLLGIVKDS TDTHARVEVH GSKKIISISK
DFLTVRDPVT GAVIQQNAGQ RPGAPPAGGA GGRPPAWGGA TPGRFGATPR ASDGGRTPAW
KPAAGGRTPA WAGAGAGGRT AYGGSGASSV PAWQRGSGGT TAYGGATTYG GQTSYGGQTS
YGGSTAYGGG TWNPNTRTPY HGGGTAYESG SKTPAYGMDA PTPGFSAPTP GNLDQPTPGY
GQYRTPAAAP TPGAFPETPG AWNAETPAGD GGPGYD
//
