ID   A0A074W6E6_9PEZI        Unreviewed;      1310 AA.
AC   A0A074W6E6;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=CNH-domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=M437DRAFT_73413 {ECO:0000313|EMBL:KEQ65497.1};
OS   Aureobasidium melanogenum CBS 110374.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Dothideomycetidae; Dothideales; Saccotheciaceae; Aureobasidium.
OX   NCBI_TaxID=1043003 {ECO:0000313|EMBL:KEQ65497.1, ECO:0000313|Proteomes:UP000030672};
RN   [1] {ECO:0000313|EMBL:KEQ65497.1, ECO:0000313|Proteomes:UP000030672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 110374 {ECO:0000313|EMBL:KEQ65497.1,
RC   ECO:0000313|Proteomes:UP000030672};
RX   PubMed=24984952;
RA   Gostin Ar C., Ohm R.A., Kogej T., Sonjak S., Turk M., Zajc J., Zalar P.,
RA   Grube M., Sun H., Han J., Sharma A., Chiniquy J., Ngan C.Y., Lipzen A.,
RA   Barry K., Grigoriev I.V., Gunde-Cimerman N.;
RT   "Genome sequencing of four Aureobasidium pullulans varieties:
RT   biotechnological potential, stress tolerance, and description of new
RT   species.";
RL   BMC Genomics 15:549-549(2014).
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DR   EMBL; KL584827; KEQ65497.1; -; Genomic_DNA.
DR   STRING; 1043003.A0A074W6E6; -.
DR   HOGENOM; CLU_001083_2_0_1; -.
DR   OrthoDB; 2734900at2759; -.
DR   Proteomes; UP000030672; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR001180; CNH_dom.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041675; PH_5.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR   PANTHER; PTHR46572:SF1; RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1; 1.
DR   Pfam; PF00780; CNH; 1.
DR   Pfam; PF15405; PH_5; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00036; CNH; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50219; CNH; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000030672}.
FT   DOMAIN          466..658
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          695..881
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          955..1260
FT                   /note="CNH"
FT                   /evidence="ECO:0000259|PROSITE:PS50219"
SQ   SEQUENCE   1310 AA;  145776 MW;  EC586C5F16B12268 CRC64;
     MAIASIINEY SDESDAEALA GLEAMRMAEA QEADANRGSA LFGYYGSSLA NLSNEADDVE
     MPMDMSTLSG GYDAHMSYGG DPSILAAGPD TNGINSLSAS NSLRRSIGSS NPDSIYDHAM
     SLGFHGPPVA RVDAGDTGGF TDPDALNRRQ SFDEGDEYSL TDNLLQPGEP PDMFFHPGHS
     IHNHDRPLPP PPIVSENAVP RLNTSLLHQR SNSLSQAPYR MTPDGYTPST MDSGAGTFPR
     SASLLNHSQT PQVLQPARSK TDAEERRLRQ GYRASIYNTF DNTPAASTVA LDLPSLPTKR
     FNPAKLGGSD FKKCEEPWAL SSILQWLFIV ADPEKMTELK ESMVKEALVA LFTNKVPTMN
     IADAEVLSNR VVENMYASKT LVPVEEWVKL SPGHMSGVIF QLTLNGCYSH TVHNHILPGR
     CYSHHCQRTL KKVNLQTIST RASEDWATFY KLKKEDVDGH DKKEIELQNN LHEIVQTEEG
     FMESLDVMIR LYRDPLATAN PSIISPNRQE RFLRDVFSKL DLVKKANVEH LLPQLKYRQQ
     EQGPWVQGFS DIFRQWIRKA RTAYIEYATG FPSANSLMRQ ELERNISFRN FVEAARMNKL
     SNKLGWDNYL KAPITRLQRY SLLLSTVHKN MQHDCEERTN LATAIEEIRA VTLECDSRVA
     DQQRKVDLSD LSQKLVLRPG MASEVELNLT SIGRELIHQG DLQRMGTNRF TWLECHALLF
     DHYLVLAKAV SVLQKGAPNK IEKYDVSRLP IPMDLLVLEN INEDAVVRSS YVKGITSVTP
     LPSKPAPSSP DLSKMTRMTT AQSAHPTLAS VNTGSSMTSL NSVASAPSKL SSTTVLDNKD
     SEKILYPFRI KHLGNKEPYT LFANNAGNRT EWYNKIIEAK TKHAAALFAQ NAEPFRLRVI
     ADSAFYYDSN ANTKDQYGVS MVGKPVIIKG TPLDRAVKEV ENRFKASGRP APICRARVNC
     ATSFTTSYPD TKHMVAVGTD FGVYCCEMDN PRGWFRSIAG TKVTQVAVLE EFNLFLVLAD
     KVLYAYHLDA VCQPLSSSTA ETPSSRKAPQ KLSGSRDVGF FAVGRMKDRT LVFYKKRDGI
     SSTFKVLEPI YQKSTEKKHG IFKRGNTEFF RDYDDFYIGT ECHGMNLFHS SLAISSDKGF
     EVLTLDKKQP WSVPDWKAPE VGNILRHVEK QETLGMLRLT DQEFLLCYNL CAVYVNKHGE
     ISRSVVMNFV ANAKSAALYG PYLVLFDNEF VEVRNAQNGR LKQIIAGKDI KCLDDGGGGT
     LSGGSTNTGI VNGVVGYGAA SRTIKIVMQH PALEKTQIVV EMVLNNEQKE
//