ID A0A074W6X8_9PEZI Unreviewed; 339 AA.
AC A0A074W6X8;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Autophagy-related protein 27 {ECO:0000256|ARBA:ARBA00013776};
GN ORFNames=M437DRAFT_71158 {ECO:0000313|EMBL:KEQ67334.1};
OS Aureobasidium melanogenum CBS 110374.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Dothideales; Saccotheciaceae; Aureobasidium.
OX NCBI_TaxID=1043003 {ECO:0000313|EMBL:KEQ67334.1, ECO:0000313|Proteomes:UP000030672};
RN [1] {ECO:0000313|EMBL:KEQ67334.1, ECO:0000313|Proteomes:UP000030672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 110374 {ECO:0000313|EMBL:KEQ67334.1,
RC ECO:0000313|Proteomes:UP000030672};
RX PubMed=24984952;
RA Gostin Ar C., Ohm R.A., Kogej T., Sonjak S., Turk M., Zajc J., Zalar P.,
RA Grube M., Sun H., Han J., Sharma A., Chiniquy J., Ngan C.Y., Lipzen A.,
RA Barry K., Grigoriev I.V., Gunde-Cimerman N.;
RT "Genome sequencing of four Aureobasidium pullulans varieties:
RT biotechnological potential, stress tolerance, and description of new
RT species.";
RL BMC Genomics 15:549-549(2014).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004358}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004358}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Preautophagosomal structure membrane
CC {ECO:0000256|ARBA:ARBA00004472}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004472}.
CC -!- SIMILARITY: Belongs to the ATG27 family.
CC {ECO:0000256|ARBA:ARBA00005363}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL584824; KEQ67334.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A074W6X8; -.
DR STRING; 1043003.A0A074W6X8; -.
DR HOGENOM; CLU_047751_0_0_1; -.
DR OrthoDB; 1332975at2759; -.
DR Proteomes; UP000030672; Unassembled WGS sequence.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.70.130.10; Mannose-6-phosphate receptor binding domain; 1.
DR InterPro; IPR018939; Autophagy-rel_prot_27.
DR InterPro; IPR009011; Man6P_isomerase_rcpt-bd_dom_sf.
DR InterPro; IPR044865; MRH_dom.
DR PANTHER; PTHR15071:SF38; AUTOPHAGY-RELATED PROTEIN 27; 1.
DR PANTHER; PTHR15071; MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER; 1.
DR Pfam; PF09451; ATG27; 1.
DR SUPFAM; SSF50911; Mannose 6-phosphate receptor domain; 1.
DR PROSITE; PS51914; MRH; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030672};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..339
FT /note="Autophagy-related protein 27"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001701187"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 21..250
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT REGION 194..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..219
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 339 AA; 37825 MW; 90A534D8DF1EECC8 CRC64;
MLGSLPALFL LSATTATAVS LDCKNVVVKG QHFDLSELAG PRAVHLIEDT PPSLSNTTFT
IDICNPLKKT KNVPKENECP TGTYVCGIEY DYNLADNSST IRKVVPIAGQ YAASHSRYLD
PEWTRLKNSA SHDDANKEGL RVELHGGRYP FEKSDGRQQK AIIEFQCDRN RTGLEGSEHD
SRDKLDEDQE AARLAIRAEP DDKKDDKKDD KEEPAEDASL KLISYRSEGE GDAEFDVLRL
QWKTKYACEG MTEHKPSSGN NTSKHWGFFT WFLIIAFLGA AAYLIFGTWL NSSKYGAQGF
DSVPHADFWR DLPYTVKDWG RSIVGMIQNR GSRGGYSAV
//
