ID A0A074W8N7_9PEZI Unreviewed; 576 AA.
AC A0A074W8N7;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=PNPLA domain-containing protein {ECO:0000259|PROSITE:PS51635};
GN ORFNames=M437DRAFT_37991 {ECO:0000313|EMBL:KEQ67949.1};
OS Aureobasidium melanogenum CBS 110374.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Dothideales; Saccotheciaceae; Aureobasidium.
OX NCBI_TaxID=1043003 {ECO:0000313|EMBL:KEQ67949.1, ECO:0000313|Proteomes:UP000030672};
RN [1] {ECO:0000313|EMBL:KEQ67949.1, ECO:0000313|Proteomes:UP000030672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 110374 {ECO:0000313|EMBL:KEQ67949.1,
RC ECO:0000313|Proteomes:UP000030672};
RX PubMed=24984952;
RA Gostin Ar C., Ohm R.A., Kogej T., Sonjak S., Turk M., Zajc J., Zalar P.,
RA Grube M., Sun H., Han J., Sharma A., Chiniquy J., Ngan C.Y., Lipzen A.,
RA Barry K., Grigoriev I.V., Gunde-Cimerman N.;
RT "Genome sequencing of four Aureobasidium pullulans varieties:
RT biotechnological potential, stress tolerance, and description of new
RT species.";
RL BMC Genomics 15:549-549(2014).
CC -!- FUNCTION: Probable lipid hydrolase. {ECO:0000256|ARBA:ARBA00002682}.
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DR EMBL; KL584824; KEQ67949.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A074W8N7; -.
DR STRING; 1043003.A0A074W8N7; -.
DR HOGENOM; CLU_009031_5_0_1; -.
DR OrthoDB; 154387at2759; -.
DR Proteomes; UP000030672; Unassembled WGS sequence.
DR GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006641; P:triglyceride metabolic process; IEA:UniProt.
DR CDD; cd07229; Pat_TGL3_like; 1.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002641; PNPLA_dom.
DR InterPro; IPR021771; Triacylglycerol_lipase_N.
DR PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR PANTHER; PTHR14226:SF44; TRIACYLGLYCEROL LIPASE 3; 1.
DR Pfam; PF11815; DUF3336; 1.
DR Pfam; PF01734; Patatin; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000030672}.
FT DOMAIN 187..389
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
FT REGION 550..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 576 AA; 64954 MW; EAE08C60202DD7E1 CRC64;
MATRSRSSSV AAFLKALIRL FCDVAFFWHM RLWAWWTRPS QKDIQLECLN SARYYEEWEA
AAFALDELFG NDLWFENPSS KHYDYRLIHS RLQYILEARE DDDILGLVNL LRSGLVRNLG
NITAPRLYNR AYAGTKLLIE DYITQVALAV EYVTAYPTSP MYDTSLTNQA KLDLLHDTRQ
ALGRSVLVLQ GGSIFGLCHI GVVKALHLRG LLPRIISGTA TGALMAALVG VHNEDELLKF
LSGEGIDLTA FATRSDQMAK NSDSGFVQHG WISTWFRRAK RFITEGYLLD SRVLEECVRA
NVGDLTFMEA YQRTKRVLNI TVAPMGNGMP NLLNYLTAPN VLIWSAALAS NASDVLYSPL
TMKCKDESGN IVPWASTHPI NPRPTTPSGY ASERDSPLTR IAELFNANHF IVSQARPYIA
PFLRSDLHSP KPGYKGRSSL TNSLMKVMVM EVQHRLHQLD SLGYLPAQIR RFLLDENIPG
TSLTLVPEVK FTDFFRLLEN PTRQSVEYWI SRGEKMVWPA VDALKVRCAV EVELDRGYQV
VRRRKPFDAS PMASAHGTVR LDKKGIKKRS SSSALE
//
