ID A0A074WEK8_9PEZI Unreviewed; 1535 AA.
AC A0A074WEK8;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=ABC drug exporter AtrF {ECO:0000313|EMBL:KEQ71520.1};
GN ORFNames=M436DRAFT_83793 {ECO:0000313|EMBL:KEQ71520.1};
OS Aureobasidium namibiae CBS 147.97.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Dothideales; Saccotheciaceae; Aureobasidium.
OX NCBI_TaxID=1043004 {ECO:0000313|EMBL:KEQ71520.1, ECO:0000313|Proteomes:UP000027730};
RN [1] {ECO:0000313|EMBL:KEQ71520.1, ECO:0000313|Proteomes:UP000027730}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 147.97 {ECO:0000313|EMBL:KEQ71520.1,
RC ECO:0000313|Proteomes:UP000027730};
RX PubMed=24984952;
RA Gostin Ar C., Ohm R.A., Kogej T., Sonjak S., Turk M., Zajc J., Zalar P.,
RA Grube M., Sun H., Han J., Sharma A., Chiniquy J., Ngan C.Y., Lipzen A.,
RA Barry K., Grigoriev I.V., Gunde-Cimerman N.;
RT "Genome sequencing of four Aureobasidium pullulans varieties:
RT biotechnological potential, stress tolerance, and description of new
RT species.";
RL BMC Genomics 15:549-549(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000256|ARBA:ARBA00006012}.
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DR EMBL; KL584714; KEQ71520.1; -; Genomic_DNA.
DR RefSeq; XP_013425723.1; XM_013570269.1.
DR STRING; 1043004.A0A074WEK8; -.
DR GeneID; 25417236; -.
DR HOGENOM; CLU_000604_35_0_1; -.
DR OrthoDB; 5473955at2759; -.
DR Proteomes; UP000027730; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03233; ABCG_PDR_domain1; 1.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR029481; ABC_trans_N.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR034001; ABCG_PDR_1.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010929; PDR_CDR_ABC.
DR PANTHER; PTHR19241:SF298; ABC MULTIDRUG TRANSPORTER (EUROFUNG); 1.
DR PANTHER; PTHR19241; ATP-BINDING CASSETTE TRANSPORTER; 1.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF14510; ABC_trans_N; 1.
DR Pfam; PF06422; PDR_CDR; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000027730};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 544..566
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 572..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 623..643
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 655..673
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 685..704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 796..829
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1216..1237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1249..1266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1286..1314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1326..1345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1357..1376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1481..1500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1506..1525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 187..431
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 875..1119
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 78..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 841..870
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..55
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1535 AA; 170763 MW; 65CE3D1FB6A2B1D7 CRC64;
MWGSGVADDP RVARMDSQGG QNAWHNPAEQ RAGRLHNDPE SQSTSSEEAD RNGTWGEHDA
GIPNEVMAME DYRALRRELT NRSRTSRPQS LGRSSRRHST ATNAVDEESV VGGNTEVQGK
DEDDFELSDF MRQGHLGQRK GDKSAKKVGV VYKNLTVKGV GAGATFVRTL PDAVLGTFGP
DLYHILSRFI PFLRSKNGEL KTLINDFSGV VRDGEMMLVL GRPGAGCTTF LKAIANNREG
YAQVDGDVSY GGISAEKQRK MYRGEVNYNM EDDVHFATLN VWQTFMFALL TKTKKKATGD
IPLIAEALMK MFGISHTKMT LVGDEYTRGV SGGERKRVSI AETLASKSTV VCWDNSTRGL
DASTALDYAK SLRIMTDVSN RTTLVTLYQA GQGIYDLMDK VLVIDQGRCI FTGPAAAAKQ
YFEDLGFQCP ERQTTADFLT AITDPVERKF RPGCEASTPK TPVELERAFR ESSFFTRNNQ
DIETYEQHLE QTNHEDAKEF EETVQAGKSK TVTKKSPYTV SFIRQVLACT KREFWLLWGD
TTTLYTKVFI IIANGLIVGS LFYGQSLNTD GAFSRGGSLF FSILFLGWLQ LTELMKAVSG
RAVVARQKEY AFYRPSAVSV ARVVADFPVI LVQVCLFTVI MYFMTGLDVD AGKFWIYFLF
VYVNTICITA LYRMFASLSP TIDDAVRFSG IALNLLIIYT GYVIPKTQLL NNYIWFGWIY
YINPISYSFE AVLANEFSGR TMQCSPDNLV PQGPGIDPAF QGCTLTGAAV NAQSVSGADY
LQTQYTYTRA HLWRNFGVVI AFTVLYLLVT IAATELFSFV GGGGGALVFK KSKKAKQQVK
AASSVDEEKA GSDSDTAVGG STGEKEEQEA LDSIVKSESI FTWRDVEYTV PYNGGERKLL
NKVNGYAKPG LMIALMGASG AGKTTLLNTL SQRQKMGVVQ GEMFVDGRPL GKEFQRNTGF
CEQMDLHDGT STIREALEFS AILRQDRKIP RAEKIAYVDN VIDLLELNDM QDAIISSLGV
EQRKRLTIGV ELAAKPSLLL FLDEPTSGLD SQSAYSIIRF LKKLTAAGQA IVCTIHQPSS
VLIQEFDMVL ALNPGGNTFY FGPIGENGKD VIEYFGARGV KCPPEKNVAE FLLETAIKPR
KRADGTKIDW NDEWANSKEA QAVIEEIDGL KRMRSKSVSE KQNDDDATEF AAPVWLQTTM
LTKRVFTQYW RDPSYLYGKL FVAVIVGIFN GFTFWQLGNS IQDMQNRMFT AFLILTIPPT
VVNAVVPKFY QNMALWMARE LPSRIYGWFA FSTAMVVAEI PIAVVSAVVY WLLWYFPSGL
PTDSSTAGYV FFMVLLFFFF QASWGQWICA FAPSFTVISN VLPFFFVMFS LFNGVVRPYA
SIPVFWRYWM YYVNPSTYWI SGVLAKTLDG IRVECTPSET ARFNVPGGQT CQSYAGAFAT
SAGGYLLNPD ATADCQYCPY EYANGYLASL NIKASQAWRD LGIFCIFVVS NWALVYFFIY
TVRIKGWSFG FGPLFGALGS MVGAIKKPFK SKKKE
//
