ID A0A074X2L7_AURPU Unreviewed; 675 AA.
AC A0A074X2L7;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Pre-mRNA-splicing factor clf1 {ECO:0000313|EMBL:KEQ79740.1};
GN ORFNames=M438DRAFT_327619 {ECO:0000313|EMBL:KEQ79740.1};
OS Aureobasidium pullulans EXF-150.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Dothideales; Saccotheciaceae; Aureobasidium.
OX NCBI_TaxID=1043002 {ECO:0000313|EMBL:KEQ79740.1, ECO:0000313|Proteomes:UP000030706};
RN [1] {ECO:0000313|EMBL:KEQ79740.1, ECO:0000313|Proteomes:UP000030706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EXF-150 {ECO:0000313|EMBL:KEQ79740.1,
RC ECO:0000313|Proteomes:UP000030706};
RX PubMed=24984952;
RA Gostin Ar C., Ohm R.A., Kogej T., Sonjak S., Turk M., Zajc J., Zalar P.,
RA Grube M., Sun H., Han J., Sharma A., Chiniquy J., Ngan C.Y., Lipzen A.,
RA Barry K., Grigoriev I.V., Gunde-Cimerman N.;
RT "Genome sequencing of four Aureobasidium pullulans varieties:
RT biotechnological potential, stress tolerance, and description of new
RT species.";
RL BMC Genomics 15:549-549(2014).
CC -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC Required for the spliceosome assembly and initiation of the DNA
CC replication. {ECO:0000256|ARBA:ARBA00037040}.
CC -!- SUBUNIT: Associated with the spliceosome.
CC {ECO:0000256|ARBA:ARBA00011524}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the crooked-neck family.
CC {ECO:0000256|ARBA:ARBA00008644}.
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DR EMBL; KL585003; KEQ79740.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A074X2L7; -.
DR STRING; 1043002.A0A074X2L7; -.
DR HOGENOM; CLU_011554_1_0_1; -.
DR OrthoDB; 5479069at2759; -.
DR Proteomes; UP000030706; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR045075; Syf1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR11246:SF3; CROOKED NECK-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR11246; PRE-MRNA SPLICING FACTOR; 1.
DR Pfam; PF02184; HAT; 1.
DR Pfam; PF14559; TPR_19; 1.
DR SMART; SM00386; HAT; 14.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|ARBA:ARBA00023187};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Reference proteome {ECO:0000313|Proteomes:UP000030706};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 72..105
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 553..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..568
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 675 AA; 81290 MW; 56517C97F28388F6 CRC64;
MESSRGPPRV KNKAAAPIQI SAEQLLREAV DRQEPGLQAP TQRFADLEEL HEHQGRKRKE
FEDYVRRNRL NMGNWMRYAA WELEQKEYRR ARSVFERALD VEPTNVPLWL RYIEAEMKTR
NINHARNLLD RAVTILPRID KLWYKYVYME ETLGNIPGTR QVFERWMSWE PSEDAWGAYI
KMEKRYGEFD RARSIFERFT IVHPESKNWI KWARFEEESG TSDHVREVFG MAIETMGEDF
MDEKLFIAYA RYEVKLKEYE RARAIYKYAL DRMPRSQSAI LHKHYTTFEK QYGDQEGVED
VVLSKRRVQY EEQVRENSKN YDAWIDYARL EESLGDAERT RDVYERAIAQ VPPTQEKRHW
RRYIYIWIFY ALWEEMENKD VERARQVYAE CQKLIPHKKF TFAKFWLLKA QFEIRQMQLQ
AARKSLGIAI GMCPKDKLFR GYIDLELKLF EFMRCRTLYE KHIEWNPANC QAWIKFAELE
RGLEDLERTR AIFELAVDQP SLDMPELLWK AYIDFEEEEG EWDRTRDLYE RLLEKTGHVK
VWISYAHFEI NVPDPDEEEA DEDEEEEKPI SENAKLRARK VFQRAYEDMK QKDLKEERVA
LLNAWKSFET THGSSSDLEK VEKQMPRRVK KRRKLSEDEW EEYMDYVFPA DDESAAKMSK
LLQMAQAWKK EQASG
//
