GenomeNet

Database: UniProt
Entry: A0A074XB72_AURPU
LinkDB: A0A074XB72_AURPU
Original site: A0A074XB72_AURPU 
ID   A0A074XB72_AURPU        Unreviewed;      1098 AA.
AC   A0A074XB72;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   05-JUN-2019, entry version 27.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=M438DRAFT_367080 {ECO:0000313|EMBL:KEQ82593.1};
OS   Aureobasidium pullulans EXF-150.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Dothideomycetes; Dothideomycetidae; Dothideales; Saccotheciaceae;
OC   Aureobasidium.
OX   NCBI_TaxID=1043002 {ECO:0000313|EMBL:KEQ82593.1, ECO:0000313|Proteomes:UP000030706};
RN   [1] {ECO:0000313|EMBL:KEQ82593.1, ECO:0000313|Proteomes:UP000030706}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EXF-150 {ECO:0000313|EMBL:KEQ82593.1,
RC   ECO:0000313|Proteomes:UP000030706};
RX   PubMed=24984952;
RA   Gostin Ar C., Ohm R.A., Kogej T., Sonjak S., Turk M., Zajc J.,
RA   Zalar P., Grube M., Sun H., Han J., Sharma A., Chiniquy J., Ngan C.Y.,
RA   Lipzen A., Barry K., Grigoriev I.V., Gunde-Cimerman N.;
RT   "Genome sequencing of four Aureobasidium pullulans varieties:
RT   biotechnological potential, stress tolerance, and description of new
RT   species.";
RL   BMC Genomics 15:549-549(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; KL584987; KEQ82593.1; -; Genomic_DNA.
DR   EnsemblFungi; KEQ82593; KEQ82593; M438DRAFT_367080.
DR   OrthoDB; 20210at2759; -.
DR   Proteomes; UP000030706; Unassembled WGS sequence.
DR   GO; GO:0043625; C:delta DNA polymerase complex; IEA:EnsemblFungi.
DR   GO; GO:0000784; C:nuclear chromosome, telomeric region; IEA:EnsemblFungi.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:1904161; P:DNA synthesis involved in UV-damage excision repair; IEA:EnsemblFungi.
DR   GO; GO:1903459; P:mitotic DNA replication lagging strand elongation; IEA:EnsemblFungi.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000030706};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030706};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      125    467       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      531    962       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     1000   1074       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION        1     57       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A074XB72}.
FT   COILED       57     84       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1098 AA;  124507 MW;  18A2579827AC3363 CRC64;
     MPAAKVQDVQ PKKRVLVDAP SSRQNIQKDS PSKRRKLNGQ PKNFKTPGGP NSSQVKSQFE
     EEVLEKLTQD LDHLKQHNAE KDQQWARPSL DDFDETRDSL CFQQIEAEEG TLHGGKTCIK
     LFGVTETGHS VLLHVTDFMH YLYVAAPTAF QQSDCESYKA YLETHLAQHQ PVIYSVQMVL
     RENLYGFQGN VKSPYLKITV TDPKHINKLR TSIESGGANY KGLWKGADGG VLTFDSIQYV
     LRFMIDTKVS GMSWVETPAS KYTVIPARDR HSNCQIEAFC HYRDLIAHPA EGEWAKMAPL
     RTLSFDIECA GRKGIFPEAN VDPVIQIANV VTRYGEEKPF VRNVFCLDTC SLIVNTQIFE
     FADEDKMLMA WRDFLEKVDP DVIIGYNISN FDFPYLLDRA KHLKCGKFPF WSRLRNVQSV
     AKDTNFSSKQ MGNRDTKATN TNGRLQLDLL QLIQRDHQLR SYTLNSVCAH FLNEQKEDVH
     HTMITELFNG TPESRRRLAV YCLKDAYLPQ RLMDKLLCLV NYTEMARVTG VPFNYLLSRG
     QQVKFISQLF RKALEQQLVI PNLRSEGTDE QYEGATVIEP TRGYYDVPIA TLDFASLYPS
     IMQAHNLCYT TLLNKNAVDK LGFKKDEDYI VTPNGDLFCT AKIRKGLLTQ ILEELLGARK
     RARKELAQEK DPFKKAVLNG RQLALKISAN SVYGITGATV GKLPCLAIAS STTSYGRQMI
     EKTRDEVQKR YTIANGYSHD AEVIYGDTDS VMVKFGPNDL AKAMELGEEA ANYVSSKFIK
     PIKLEFEKVY FPYLLINKKR YAGLYWTNPN KWDKMDSKGI ETVRRDNCRL VQTVIETSLR
     MLLIDRDVQG AQDFVKETIA ELLQNKVDMS NLVITKALTK NDYAAKQAHV ELAERMKKRD
     AGSAPALGDR VAYVMVKGAA GAKNYEKSED PIFVLENNLP IDTRYYLDNQ LAKPLGRIFE
     PILGEKKAGQ LLTGEHTRSI SVAAPTMGGL MKFAKKTETC MGCKKPLTGK DEKGGAVCEN
     DRDRLGELYQ KTLSKVAELE VRFARLWTQC QRCQGSMHNE VICSSRDCPI FYMRMKAKKD
     VEDSGKELVR FDNDGALW
//
DBGET integrated database retrieval system