ID A0A074YN72_AURSE Unreviewed; 496 AA.
AC A0A074YN72;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=General transcription and DNA repair factor IIH {ECO:0000256|PIRNR:PIRNR015919};
GN ORFNames=AUEXF2481DRAFT_36561 {ECO:0000313|EMBL:KEQ99248.1};
OS Aureobasidium subglaciale (strain EXF-2481) (Aureobasidium pullulans var.
OS subglaciale).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Dothideales; Saccotheciaceae; Aureobasidium.
OX NCBI_TaxID=1043005 {ECO:0000313|EMBL:KEQ99248.1, ECO:0000313|Proteomes:UP000030641};
RN [1] {ECO:0000313|EMBL:KEQ99248.1, ECO:0000313|Proteomes:UP000030641}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EXF-2481 {ECO:0000313|EMBL:KEQ99248.1,
RC ECO:0000313|Proteomes:UP000030641};
RX PubMed=24984952;
RA Gostin Ar C., Ohm R.A., Kogej T., Sonjak S., Turk M., Zajc J., Zalar P.,
RA Grube M., Sun H., Han J., Sharma A., Chiniquy J., Ngan C.Y., Lipzen A.,
RA Barry K., Grigoriev I.V., Gunde-Cimerman N.;
RT "Genome sequencing of four Aureobasidium pullulans varieties:
RT biotechnological potential, stress tolerance, and description of new
RT species.";
RL BMC Genomics 15:549-549(2014).
CC -!- FUNCTION: Component of the general transcription and DNA repair factor
CC IIH (TFIIH) core complex, which is involved in general and
CC transcription-coupled nucleotide excision repair (NER) of damaged DNA
CC and, when complexed to TFIIK, in RNA transcription by RNA polymerase
CC II. {ECO:0000256|PIRNR:PIRNR015919}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR015919}.
CC -!- SIMILARITY: Belongs to the GTF2H2 family.
CC {ECO:0000256|ARBA:ARBA00006092, ECO:0000256|PIRNR:PIRNR015919}.
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DR EMBL; KL584751; KEQ99248.1; -; Genomic_DNA.
DR RefSeq; XP_013347518.1; XM_013492064.1.
DR AlphaFoldDB; A0A074YN72; -.
DR STRING; 1043005.A0A074YN72; -.
DR GeneID; 25365600; -.
DR HOGENOM; CLU_028556_2_0_1; -.
DR InParanoid; A0A074YN72; -.
DR OMA; INWVEVP; -.
DR OrthoDB; 276422at2759; -.
DR Proteomes; UP000030641; Unassembled WGS sequence.
DR GO; GO:0000439; C:transcription factor TFIIH core complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005675; C:transcription factor TFIIH holo complex; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:UniProtKB-UniRule.
DR CDD; cd01453; vWA_transcription_factor_IIH_type; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR007198; Ssl1-like.
DR InterPro; IPR004595; TFIIH_C1-like_dom.
DR InterPro; IPR012170; TFIIH_SSL1/p44.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR NCBIfam; TIGR00622; ssl1; 1.
DR PANTHER; PTHR12695; GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2; 1.
DR PANTHER; PTHR12695:SF2; GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED; 1.
DR Pfam; PF07975; C1_4; 1.
DR Pfam; PF04056; Ssl1; 1.
DR PIRSF; PIRSF015919; TFIIH_SSL1; 1.
DR SMART; SM01047; C1_4; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRNR:PIRNR015919};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR015919};
KW Reference proteome {ECO:0000313|Proteomes:UP000030641};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR015919};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR015919};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRNR:PIRNR015919};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 101..280
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT ZN_FING 333..350
FT /note="C4-type"
FT /evidence="ECO:0000256|PIRSR:PIRSR015919-1"
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 496 AA; 53701 MW; 97264D147D02D3E3 CRC64;
MAHHDNDYDM DMSDDANEDL NTRNSHSNGA SRTQDLGKTK AGSKNAEGSR ARWEAGAQKN
WDLHEGDDGN LSNVLGGMEE ATKRLRLQKD TTPLQRGIIR HCLLVLDLSL AMLEKDLRPT
RFLLTISNTM SFVREFFEQN PISQLGILGM RDGLAVRISE LSGNPNDHIT ALKELRNTEP
KGAASLQNAL DMARAALYHT PSHGTREVVI ILGALSSSDP GDIHATINAC VRDKLRVTVI
GLAAQMHICA DLCARTNSGD TSSYNVALDE QHYRELLLQI TTPPVMRTTK SSPNTTEASK
SALLQMGFPS RYTEEKATLC ACHGVLTQGG YNCSRCAAKV CSLPQTCPAC DLTLILSTHL
ARSYHHLFPL LLWNEVSWSR AVQKKSTRCY GCLSPFPHVA RGGDGVAGAG QGKRAEGASE
SSRYECPSCE RHFCVDCDVF CHEVVHNCPG CTSGRVMADG DGMRGNGDQE DGDVVMNGHV
NGSNSNGNGF AVAVAA
//