GenomeNet

Database: UniProt
Entry: A0A074YN72_AURSE
LinkDB: A0A074YN72_AURSE
Original site: A0A074YN72_AURSE 
ID   A0A074YN72_AURSE        Unreviewed;       496 AA.
AC   A0A074YN72;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   24-JAN-2024, entry version 42.
DE   RecName: Full=General transcription and DNA repair factor IIH {ECO:0000256|PIRNR:PIRNR015919};
GN   ORFNames=AUEXF2481DRAFT_36561 {ECO:0000313|EMBL:KEQ99248.1};
OS   Aureobasidium subglaciale (strain EXF-2481) (Aureobasidium pullulans var.
OS   subglaciale).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Dothideomycetidae; Dothideales; Saccotheciaceae; Aureobasidium.
OX   NCBI_TaxID=1043005 {ECO:0000313|EMBL:KEQ99248.1, ECO:0000313|Proteomes:UP000030641};
RN   [1] {ECO:0000313|EMBL:KEQ99248.1, ECO:0000313|Proteomes:UP000030641}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EXF-2481 {ECO:0000313|EMBL:KEQ99248.1,
RC   ECO:0000313|Proteomes:UP000030641};
RX   PubMed=24984952;
RA   Gostin Ar C., Ohm R.A., Kogej T., Sonjak S., Turk M., Zajc J., Zalar P.,
RA   Grube M., Sun H., Han J., Sharma A., Chiniquy J., Ngan C.Y., Lipzen A.,
RA   Barry K., Grigoriev I.V., Gunde-Cimerman N.;
RT   "Genome sequencing of four Aureobasidium pullulans varieties:
RT   biotechnological potential, stress tolerance, and description of new
RT   species.";
RL   BMC Genomics 15:549-549(2014).
CC   -!- FUNCTION: Component of the general transcription and DNA repair factor
CC       IIH (TFIIH) core complex, which is involved in general and
CC       transcription-coupled nucleotide excision repair (NER) of damaged DNA
CC       and, when complexed to TFIIK, in RNA transcription by RNA polymerase
CC       II. {ECO:0000256|PIRNR:PIRNR015919}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PIRNR:PIRNR015919}.
CC   -!- SIMILARITY: Belongs to the GTF2H2 family.
CC       {ECO:0000256|ARBA:ARBA00006092, ECO:0000256|PIRNR:PIRNR015919}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KL584751; KEQ99248.1; -; Genomic_DNA.
DR   RefSeq; XP_013347518.1; XM_013492064.1.
DR   AlphaFoldDB; A0A074YN72; -.
DR   STRING; 1043005.A0A074YN72; -.
DR   GeneID; 25365600; -.
DR   HOGENOM; CLU_028556_2_0_1; -.
DR   InParanoid; A0A074YN72; -.
DR   OMA; INWVEVP; -.
DR   OrthoDB; 276422at2759; -.
DR   Proteomes; UP000030641; Unassembled WGS sequence.
DR   GO; GO:0000439; C:transcription factor TFIIH core complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005675; C:transcription factor TFIIH holo complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:UniProtKB-UniRule.
DR   CDD; cd01453; vWA_transcription_factor_IIH_type; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR046349; C1-like_sf.
DR   InterPro; IPR007198; Ssl1-like.
DR   InterPro; IPR004595; TFIIH_C1-like_dom.
DR   InterPro; IPR012170; TFIIH_SSL1/p44.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   NCBIfam; TIGR00622; ssl1; 1.
DR   PANTHER; PTHR12695; GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2; 1.
DR   PANTHER; PTHR12695:SF2; GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED; 1.
DR   Pfam; PF07975; C1_4; 1.
DR   Pfam; PF04056; Ssl1; 1.
DR   PIRSF; PIRSF015919; TFIIH_SSL1; 1.
DR   SMART; SM01047; C1_4; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRNR:PIRNR015919};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR015919};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030641};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|PIRNR:PIRNR015919};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|PIRNR:PIRNR015919};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRNR:PIRNR015919};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          101..280
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   ZN_FING         333..350
FT                   /note="C4-type"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR015919-1"
FT   REGION          1..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..40
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   496 AA;  53701 MW;  97264D147D02D3E3 CRC64;
     MAHHDNDYDM DMSDDANEDL NTRNSHSNGA SRTQDLGKTK AGSKNAEGSR ARWEAGAQKN
     WDLHEGDDGN LSNVLGGMEE ATKRLRLQKD TTPLQRGIIR HCLLVLDLSL AMLEKDLRPT
     RFLLTISNTM SFVREFFEQN PISQLGILGM RDGLAVRISE LSGNPNDHIT ALKELRNTEP
     KGAASLQNAL DMARAALYHT PSHGTREVVI ILGALSSSDP GDIHATINAC VRDKLRVTVI
     GLAAQMHICA DLCARTNSGD TSSYNVALDE QHYRELLLQI TTPPVMRTTK SSPNTTEASK
     SALLQMGFPS RYTEEKATLC ACHGVLTQGG YNCSRCAAKV CSLPQTCPAC DLTLILSTHL
     ARSYHHLFPL LLWNEVSWSR AVQKKSTRCY GCLSPFPHVA RGGDGVAGAG QGKRAEGASE
     SSRYECPSCE RHFCVDCDVF CHEVVHNCPG CTSGRVMADG DGMRGNGDQE DGDVVMNGHV
     NGSNSNGNGF AVAVAA
//
DBGET integrated database retrieval system