ID A0A074Z0H4_9TREM Unreviewed; 910 AA.
AC A0A074Z0H4;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Iron hydrogenase large subunit C-terminal domain-containing protein {ECO:0000259|Pfam:PF02906};
GN ORFNames=T265_11005 {ECO:0000313|EMBL:KER20443.1};
OS Opisthorchis viverrini.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Opisthorchis.
OX NCBI_TaxID=6198 {ECO:0000313|EMBL:KER20443.1, ECO:0000313|Proteomes:UP000054324};
RN [1] {ECO:0000313|EMBL:KER20443.1, ECO:0000313|Proteomes:UP000054324}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Young N.D., Nagarajan N., Lin S.J., Korhonen P.K., Jex A.R., Hall R.S.,
RA Safavi-Hemami H., Kaewkong W., Bertrand D., Gao S., Seet Q., Wongkham S.,
RA Teh B.T., Wongkham C., Intapan P.M., Maleewong W., Yang X., Hu M., Wang Z.,
RA Hofmann A., Sternberg P.W., Tan P., Wang J., Gasser R.B.;
RT "Opisthorchis viverrini - life in the bile duct.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the cytosolic iron-sulfur (Fe/S) protein
CC assembly machinery. Required for maturation of extramitochondrial Fe/S
CC proteins. {ECO:0000256|ARBA:ARBA00025700}.
CC -!- SIMILARITY: Belongs to the NARF family.
CC {ECO:0000256|ARBA:ARBA00006596}.
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DR EMBL; KL597057; KER20443.1; -; Genomic_DNA.
DR RefSeq; XP_009175806.1; XM_009177542.1.
DR AlphaFoldDB; A0A074Z0H4; -.
DR STRING; 6198.A0A074Z0H4; -.
DR GeneID; 20325173; -.
DR KEGG; ovi:T265_11005; -.
DR CTD; 20325173; -.
DR OrthoDB; 5477067at2759; -.
DR Proteomes; UP000054324; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1780; -; 1.
DR InterPro; IPR009016; Fe_hydrogenase.
DR InterPro; IPR004108; Fe_hydrogenase_lsu_C.
DR PANTHER; PTHR11615:SF258; CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR CG17683-RELATED; 1.
DR PANTHER; PTHR11615; NITRATE, FORMATE, IRON DEHYDROGENASE; 1.
DR Pfam; PF02906; Fe_hyd_lg_C; 1.
DR SUPFAM; SSF53920; Fe-only hydrogenase; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000054324};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 346..723
FT /note="Iron hydrogenase large subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02906"
SQ SEQUENCE 910 AA; 101232 MW; B8255C861D6B2BEF CRC64;
MRTSSNPNAA VAGCAWVVIV LIHWMERFLH DWILVDTWLC AVRLATSVKQ SNKLEVDRCP
LGLVQLRLNK MVSDGDRVIL TVPGWRHYKI WLPTDVNGVL VISSYPDCLS ECQEVPPPST
FILFFTIRLS CKSWLYGSEA SVLTLMSMMM KVPELAIFQH YQLNCARKEL WGIQWLRCGW
FNREFTDRKS RGSNPTSASR LLSRLGLSGG NPNSQASLTR QSCIKPVKVD TQGGRTKSIR
IEQDGTYTAV TETGESYTLK KASISLNDCL ACSGCITTAE SVLISEHSAP TFLNVLRQRD
QASSSKRTIV VSISPQSIVS LASYLNKNDA VRYKEWKAKF STDLEGLPEA ECTERFLVQQ
FRAMGVGLVL NTTWFRDIAL SESAAEFIRR FTAANSDPTG AHLPVFCGAC PGWICYAEKT
HTGVETSKET TKFVNQSFSI LPHLSVVRSP QQIAGSLLKR LSESQQSSLY HVTIMPCFDK
KLEASRTEFA SPAHSARQDD PEMVPDVDLV LATNELLEIL DTVYEEITDQ GPLSMKEPVN
VECDLWQILK GSHISSVNGA VHSPMPEPTP LRTPMYRHAG SGSGGYALFV FAQAAAELFS
IHLPPDDPTS DDRVLTRTLQ NQDLQELLLF ASSQDCATAK QMLSNLPNSR TPYRSIKSVK
PPACLLAFAV ANGFRNIQNL VQSLKNVYKA RHCMENQPTA RSTCYPFDYV EIMACPGGCI
NGGGQLKGTF EQAFTFYHEL PSMRPMSTWI AQQIGAYVDQ TDPEHRSLHT QYREVPKIEI
INPSALQWTE HTRLIPKGNL FPSMAYKFSP GCVKRMPNHK AKLFRSSNIV CITTGSDPRR
AMSSAYCTLL QQAKSSDIVV VAGDMNAQVG VPVTSSVLGW RRCKEWRLID VSGVRAVNFF
PVCLIGRLEA
//
