ID   A0A074Z0U2_9TREM        Unreviewed;       594 AA.
AC   A0A074Z0U2;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=Bcl-2 Bcl-2 homology region 1-3 domain-containing protein {ECO:0000259|Pfam:PF00452};
GN   ORFNames=T265_12016 {ECO:0000313|EMBL:KER19087.1};
OS   Opisthorchis viverrini.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Opisthorchis.
OX   NCBI_TaxID=6198 {ECO:0000313|EMBL:KER19087.1, ECO:0000313|Proteomes:UP000054324};
RN   [1] {ECO:0000313|EMBL:KER19087.1, ECO:0000313|Proteomes:UP000054324}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Young N.D., Nagarajan N., Lin S.J., Korhonen P.K., Jex A.R., Hall R.S.,
RA   Safavi-Hemami H., Kaewkong W., Bertrand D., Gao S., Seet Q., Wongkham S.,
RA   Teh B.T., Wongkham C., Intapan P.M., Maleewong W., Yang X., Hu M., Wang Z.,
RA   Hofmann A., Sternberg P.W., Tan P., Wang J., Gasser R.B.;
RT   "Opisthorchis viverrini - life in the bile duct.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the Bcl-2 family.
CC       {ECO:0000256|ARBA:ARBA00009458}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KL597341; KER19087.1; -; Genomic_DNA.
DR   RefSeq; XP_009177168.1; XM_009178904.1.
DR   AlphaFoldDB; A0A074Z0U2; -.
DR   STRING; 6198.A0A074Z0U2; -.
DR   GeneID; 20326184; -.
DR   KEGG; ovi:T265_12016; -.
DR   CTD; 20326184; -.
DR   OrthoDB; 4028889at2759; -.
DR   Proteomes; UP000054324; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   Gene3D; 1.10.437.10; Blc2-like; 2.
DR   InterPro; IPR036834; Bcl-2-like_sf.
DR   InterPro; IPR046371; Bcl-2_BH1-3.
DR   InterPro; IPR026298; Bcl-2_fam.
DR   InterPro; IPR002475; Bcl2-like.
DR   InterPro; IPR020726; Bcl2_BH2_motif_CS.
DR   PANTHER; PTHR11256:SF50; APOPTOSIS REGULATOR CED-9; 1.
DR   PANTHER; PTHR11256; BCL-2 RELATED; 1.
DR   Pfam; PF00452; Bcl-2; 1.
DR   SUPFAM; SSF56854; Bcl-2 inhibitors of programmed cell death; 2.
DR   PROSITE; PS50062; BCL2_FAMILY; 1.
DR   PROSITE; PS01258; BH2; 1.
PE   3: Inferred from homology;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054324};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        569..590
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          379..419
FT                   /note="Bcl-2 Bcl-2 homology region 1-3"
FT                   /evidence="ECO:0000259|Pfam:PF00452"
FT   REGION          28..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          261..294
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          345..369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          459..494
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..119
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        268..294
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        351..369
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   594 AA;  63561 MW;  4C7CE5F519D1EF65 CRC64;
     MAESQRSRNL GLDLGSYIQG KSFNRSVSIS ESSHPDFSPP AALAESGAST TFPVSTRRIL
     SGGDAMSEPS PSPLSSATAT ISPESPPLTS SSIFPVSAAS EHESPVESET PPNLYPPHTT
     AEITSQLMTA TPVTSAVNPL SCCSTAVTAQ SSTFAIRAKN PYTSTFSTLF QNPVTHRTVS
     LLSHLIDSRL SPEWRTALFI RTTPSTTTPS PVLHTSDLLV TGSGVLFSPS TAVDSTDSAP
     LRRVPPLVSS PSDEVAVTKR FKHSDDSDLL PTNNLNKTAS EPRPPTFSTV TAGTSSGQSV
     DTFVSLRLVT CVCRLADHFE SRYRDKLGDL LEDVARLSAS HTEAESGADS AIDVMSSTTE
     GNDTPSNGAD DVSAMLIRSA RCRFHQVLNE LFRERINWGR VVAMFAFVRA LCEHVETEAE
     VRSHTVVCSG AEDDERDRVT RPFTTAECAD VDAVTEVTSS SSQTTATITP VMDNSDGRPV
     STDQTHKSTA NGSELSPKFT GLRAAHYVAW TAEFIHGSHG IWDWITANGG WDGLIKFESE
     RGIYDSTAGG DRILVGFTED DAMRLLRRAV TGVATLAVGA VGLVAALRYF SKRM
//