ID A0A074Z2L6_9TREM Unreviewed; 1021 AA.
AC A0A074Z2L6;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Integrin alpha second immunoglobulin-like domain-containing protein {ECO:0000259|Pfam:PF20805};
GN ORFNames=T265_10413 {ECO:0000313|EMBL:KER21203.1};
OS Opisthorchis viverrini.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Opisthorchis.
OX NCBI_TaxID=6198 {ECO:0000313|EMBL:KER21203.1, ECO:0000313|Proteomes:UP000054324};
RN [1] {ECO:0000313|EMBL:KER21203.1, ECO:0000313|Proteomes:UP000054324}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Young N.D., Nagarajan N., Lin S.J., Korhonen P.K., Jex A.R., Hall R.S.,
RA Safavi-Hemami H., Kaewkong W., Bertrand D., Gao S., Seet Q., Wongkham S.,
RA Teh B.T., Wongkham C., Intapan P.M., Maleewong W., Yang X., Hu M., Wang Z.,
RA Hofmann A., Sternberg P.W., Tan P., Wang J., Gasser R.B.;
RT "Opisthorchis viverrini - life in the bile duct.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL596984; KER21203.1; -; Genomic_DNA.
DR RefSeq; XP_009175043.1; XM_009176779.1.
DR AlphaFoldDB; A0A074Z2L6; -.
DR STRING; 6198.A0A074Z2L6; -.
DR GeneID; 20324581; -.
DR KEGG; ovi:T265_10413; -.
DR CTD; 20324581; -.
DR OrthoDB; 2911572at2759; -.
DR Proteomes; UP000054324; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF133; INTEGRIN ALPHA-PS2; 1.
DR Pfam; PF01839; FG-GAP; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 1.
DR PROSITE; PS51470; FG_GAP; 3.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000054324};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 23..1021
FT /note="Integrin alpha second immunoglobulin-like domain-
FT containing protein"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5001422737"
FT REPEAT 43..99
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 353..416
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 480..541
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 857..950
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT REGION 393..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 977..1021
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 981..1021
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1021 AA; 112040 MW; D19871C672F965D6 CRC64;
MLRSKTNWIF LFDYYVVLLV AASAPRTEKY SQVPEDDLLF PPNAVQRYAH TKPGSYFGYS
VASYVGQSQS FCLVGAPRAS QDRPGDLLAD FGSSSSDPSS ATGLVYRIDL DFKLPYCSVV
PIATTDEARR EHGTPTPGIS SWLGGTVAAA SNAQNGIQLG CDPRYIYAPE PINQTDGIRP
TDSRPLHSQN LLGTGQCALY TGASMQYTSV DACIGQEEGA CLAGFSADVE TGTAFGEAHV
VLGMPGSYLT EGNVFLGHYR GRELVNAMRL KSSPQDLKHK GFNLGYAVLL DELVRKSVPH
PTPARHQNGP DVESVGLDRR VRLSLLVSSS MWLDNDYRGI VMILDQAMDL GGITYLKDQW
GHIGSFFGYS LATADLDGNG IADIIVGSPY FTERKDDKDQ DDSDWSVKSA KSNRPRDTLN
APREEEERDS DPNIVDRLWG RLLPDIGRVY VFHGFPSNLT SNTLVNSDSL RPDYLSRPPV
ILDGPKSVGG RFGHSVVSMG DVDGDSTEDL AISCPYCSDP EGTREKGAVF IYLGKKDTIL
EDEPFQVIWP AELPRAAPIT TCGDFDTHDS GHRMFKSFGR SLSAGIDLDG NHPPDLIAGD
FEKTSCSPVN NNNSDNTKNR PFVTPLRCLA AITPGGSTGA GILPYCPTLM RSGRNAEIGF
EPRTVVFLRA RNTIWFDSPE WDLPLARTLP WSGPDETECG TQCQFRVQLS VRVHGKPSLL
QRHQTEQFKL HVAVDMDASI VNLVYKRLAG VSDMQNAGGN GFMSMGLLES VVPITIIRDT
LMNANRMVLL SLTLEPQSAR VRPYIWKPIL LNATITPAFN AMPHVPGPKE VNSWMLHPFL
GERHFVSRPL QFANPACGAD NICYADLQVR MMDMSVGALE KLVVYFRERV TQRNLTVGVG
NLGENAYAAQ LRMTIPHQFS FVIPEELHCQ SKVLPDIQAT QIFRELGDPL GFTGRNLRPF
VVQLNTAGAF RELDELVNDE PATSPNASEA SLEPSSKPYW SPSDGSRGPL SQKTPSKSQR
K
//
