ID A0A074Z2W8_AURSE Unreviewed; 466 AA.
AC A0A074Z2W8;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Probable kinetochore protein NUF2 {ECO:0000256|ARBA:ARBA00017594};
GN ORFNames=AUEXF2481DRAFT_24916 {ECO:0000313|EMBL:KER00608.1};
OS Aureobasidium subglaciale (strain EXF-2481) (Aureobasidium pullulans var.
OS subglaciale).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Dothideales; Saccotheciaceae; Aureobasidium.
OX NCBI_TaxID=1043005 {ECO:0000313|EMBL:KER00608.1, ECO:0000313|Proteomes:UP000030641};
RN [1] {ECO:0000313|EMBL:KER00608.1, ECO:0000313|Proteomes:UP000030641}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EXF-2481 {ECO:0000313|EMBL:KER00608.1,
RC ECO:0000313|Proteomes:UP000030641};
RX PubMed=24984952;
RA Gostin Ar C., Ohm R.A., Kogej T., Sonjak S., Turk M., Zajc J., Zalar P.,
RA Grube M., Sun H., Han J., Sharma A., Chiniquy J., Ngan C.Y., Lipzen A.,
RA Barry K., Grigoriev I.V., Gunde-Cimerman N.;
RT "Genome sequencing of four Aureobasidium pullulans varieties:
RT biotechnological potential, stress tolerance, and description of new
RT species.";
RL BMC Genomics 15:549-549(2014).
CC -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC NDC80 complex, which is required for chromosome segregation and spindle
CC checkpoint activity. {ECO:0000256|ARBA:ARBA00002772}.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NUF2 family.
CC {ECO:0000256|ARBA:ARBA00005498}.
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DR EMBL; KL584749; KER00608.1; -; Genomic_DNA.
DR RefSeq; XP_013349118.1; XM_013493664.1.
DR AlphaFoldDB; A0A074Z2W8; -.
DR STRING; 1043005.A0A074Z2W8; -.
DR GeneID; 25362870; -.
DR HOGENOM; CLU_025461_2_1_1; -.
DR InParanoid; A0A074Z2W8; -.
DR OMA; YLKMEAH; -.
DR OrthoDB; 7316at2759; -.
DR Proteomes; UP000030641; Unassembled WGS sequence.
DR GO; GO:0031262; C:Ndc80 complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 1.10.418.60; Ncd80 complex, Nuf2 subunit; 1.
DR InterPro; IPR005549; Kinetochore_Nuf2_N.
DR InterPro; IPR041112; Nuf2_DHR10-like.
DR InterPro; IPR038275; Nuf2_N_sf.
DR PANTHER; PTHR21650:SF2; KINETOCHORE PROTEIN NUF2; 1.
DR PANTHER; PTHR21650; MEMBRALIN/KINETOCHORE PROTEIN NUF2; 1.
DR Pfam; PF03800; Nuf2; 1.
DR Pfam; PF18595; Nuf2_DHR10-like; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000030641}.
FT DOMAIN 30..170
FT /note="Kinetochore protein Nuf2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03800"
FT DOMAIN 284..399
FT /note="Nuf2 DHR10-like"
FT /evidence="ECO:0000259|Pfam:PF18595"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 373..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 170..253
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 385..414
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 466 AA; 54194 MW; 0BFCAB863F0E2D9E CRC64;
MAYSGRMSMA PRGSQQPASQ PRARKEDNED AFMTLPDREI AGCISDIGIP FTIQDLQKPN
PQQIQKVFEW LAELLMNTTR EVVAPAMKAA ADDLCGDDPD RIFTADTRDL MGFFVTLRRL
LLECGVKDFT FQDLYKPTHP RLVKIFSYVI NFIRFRESQT SVIDEYFNST ERTKAQIEEL
YNSNQEKEEM LQEMQRNRKN VEQAMRDKEK KNSELKARLL ELKKGQEKVA EKLDRVKSEQ
SRLKQTLEDK QTQAINVRKE ADKLRPYTQQ SPAALESALR DLNANLTADK SEIDRLDRRT
RALQTSTDTF TLLHGDVAGL TRLLEDLQSE LKKEDEEASR ANKHRDALSE RSNNVREIER
QERMLSKQLA NIQDRTNTLR QGASTKADEA KRRMESLKQT HSELGEERRK RGEEVERRRI
RIEQTEKKMA DLKENIDSEV QSAKEEYLKM ESHIKLYITE MEQSLV
//
