ID A0A074Z339_9TREM Unreviewed; 425 AA.
AC A0A074Z339;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=inositol-phosphate phosphatase {ECO:0000256|ARBA:ARBA00013106};
DE EC=3.1.3.25 {ECO:0000256|ARBA:ARBA00013106};
DE AltName: Full=Inositol-1(or 4)-monophosphatase 3 {ECO:0000256|ARBA:ARBA00042949};
DE AltName: Full=Myo-inositol monophosphatase A3 {ECO:0000256|ARBA:ARBA00042119};
GN ORFNames=T265_10261 {ECO:0000313|EMBL:KER21418.1};
OS Opisthorchis viverrini.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Opisthorchis.
OX NCBI_TaxID=6198 {ECO:0000313|EMBL:KER21418.1, ECO:0000313|Proteomes:UP000054324};
RN [1] {ECO:0000313|EMBL:KER21418.1, ECO:0000313|Proteomes:UP000054324}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Young N.D., Nagarajan N., Lin S.J., Korhonen P.K., Jex A.R., Hall R.S.,
RA Safavi-Hemami H., Kaewkong W., Bertrand D., Gao S., Seet Q., Wongkham S.,
RA Teh B.T., Wongkham C., Intapan P.M., Maleewong W., Yang X., Hu M., Wang Z.,
RA Hofmann A., Sternberg P.W., Tan P., Wang J., Gasser R.B.;
RT "Opisthorchis viverrini - life in the bile duct.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a myo-inositol phosphate + H2O = myo-inositol + phosphate;
CC Xref=Rhea:RHEA:24056, ChEBI:CHEBI:15377, ChEBI:CHEBI:17268,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:84139; EC=3.1.3.25;
CC Evidence={ECO:0000256|ARBA:ARBA00001033};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol
CC from D-glucose 6-phosphate: step 2/2. {ECO:0000256|ARBA:ARBA00005152}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the inositol monophosphatase superfamily.
CC {ECO:0000256|ARBA:ARBA00009759}.
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DR EMBL; KL596969; KER21418.1; -; Genomic_DNA.
DR RefSeq; XP_009174844.1; XM_009176580.1.
DR AlphaFoldDB; A0A074Z339; -.
DR STRING; 6198.A0A074Z339; -.
DR GeneID; 20324429; -.
DR KEGG; ovi:T265_10261; -.
DR CTD; 20324429; -.
DR OrthoDB; 3665671at2759; -.
DR Proteomes; UP000054324; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.190.80; -; 1.
DR Gene3D; 3.30.540.10; Fructose-1,6-Bisphosphatase, subunit A, domain 1; 1.
DR InterPro; IPR000760; Inositol_monophosphatase-like.
DR InterPro; IPR020550; Inositol_monophosphatase_CS.
DR PANTHER; PTHR43028; 3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1; 1.
DR PANTHER; PTHR43028:SF4; INOSITOL MONOPHOSPHATASE 3; 1.
DR Pfam; PF00459; Inositol_P; 1.
DR SUPFAM; SSF56655; Carbohydrate phosphatase; 1.
DR PROSITE; PS00630; IMP_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054324};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 64..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 425 AA; 46694 MW; C33B1FAA58C6518C CRC64;
MEPVANFGVF GTLTHCSGSS DSVTHLHNGS DYFTQSGLST QFVFCQRGNF PYTEMMTFRL
NKHGWTILLI SVIVLLLYYF SNVGSITPLR GNVISVKRLL IRCVHLTENA GTVIRSSYKS
SNLHARIKGL SEGGGGGPKN ELLTDIDLKS HHIIVSGLAS DFADLKVISE EHPPVLEGAP
YLGPEVFHSD VESRLPNADL FIPVSDLTLW VDPLDATQEL TEGLLEYVTV MVCVALHGHP
IIGIIHQPFL NRTYWSWKSL SPFNSFTLSP TLVQTLANVS KIQSDSPLTV THSRSHLDTS
ATKTIADTFS PQPVQFIPAG GSGFKVLSLI QRKAHLYVHP TRTRRWDVCA AQAVLESTGG
RMTGLDTSSL TYDANSPHEI DAATGLFAAA SVELHDRWKE KLSKLRCMSG VIFRIAQSQH
GYYST
//
