ID A0A074ZEX3_9TREM Unreviewed; 1628 AA.
AC A0A074ZEX3;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 13-SEP-2023, entry version 34.
DE RecName: Full=RhoGAP domain protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=T265_08105 {ECO:0000313|EMBL:KER24167.1};
OS Opisthorchis viverrini.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Opisthorchis.
OX NCBI_TaxID=6198 {ECO:0000313|EMBL:KER24167.1, ECO:0000313|Proteomes:UP000054324};
RN [1] {ECO:0000313|EMBL:KER24167.1, ECO:0000313|Proteomes:UP000054324}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Young N.D., Nagarajan N., Lin S.J., Korhonen P.K., Jex A.R., Hall R.S.,
RA Safavi-Hemami H., Kaewkong W., Bertrand D., Gao S., Seet Q., Wongkham S.,
RA Teh B.T., Wongkham C., Intapan P.M., Maleewong W., Yang X., Hu M., Wang Z.,
RA Hofmann A., Sternberg P.W., Tan P., Wang J., Gasser R.B.;
RT "Opisthorchis viverrini - life in the bile duct.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KL596820; KER24167.1; -; Genomic_DNA.
DR RefSeq; XP_009172076.1; XM_009173812.1.
DR STRING; 6198.A0A074ZEX3; -.
DR GeneID; 20322284; -.
DR KEGG; ovi:T265_08105; -.
DR CTD; 20322284; -.
DR OrthoDB; 2997116at2759; -.
DR Proteomes; UP000054324; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23175; PDZ DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23175:SF23; PDZ DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000054324}.
FT DOMAIN 5..89
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1127..1319
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 239..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 478..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 797..833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 879..925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1394..1421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1469..1499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1558..1580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 801..824
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 901..924
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1479..1499
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1628 AA; 176528 MW; 74F98C43BF553B70 CRC64;
MTSYTVITIK PSAGSLGFTF EDTNEAANPR ILSVNPNGNA FKAGLRAGQT ILSVGPTPVA
GLTTVEIHDL VERLAARFGD VTLHVADDRV MDPDPRSQPL DAGDGDQWVS VPFSPTQGER
DLPLVRKQAY RPPMVRDEFT VDSKSIDRRS SPVPCTVTLM EFTAASGHAA APSPQISYKP
RHTQLAYGST ADAVTQSGLG AVARLAIDGG LSADELMHIG HTSSQPGPVT VNVQPNPAFA
RPDSGSHTVR TLRYGRSPPY STPGPQRLSR PVCQPISYCT TQPIRASQSP DWPRGQHWSR
ARQQTRPFGV RNPLGNVTST AVWYSSSRRG SFPLQMTRVG GLILHPTASS SPDSGEFAAC
KLPHEHRLTY QSMSACTSPT SGKHANTSSS SPSTTFFSAS APSPLTTPPL PVSSAPTGFR
DIVRLGPGDT VVHAAPGDTI YNVTDLIRMH DCPQPYVSMS HPDEFPPVAC GCVPDGESVQ
VHDRTRSPLA ATPPQPKDGT ESGTTVLPKF TFYRDATSNP TAGDLMDFRH STPDHFYPQS
HPPQFLPTRA ATGFSSPPGP QVARTVRHLR RIRHIFGNPL DYESSNNSAS LGALVLPSDK
VGSSTNSLVE IRSHGSRSVD SVRPSSYTCK CPPNSIPFFL SDMSVEGAST VIPPSVPHSC
TALVRFEVPS RTEDNFPNTA PWERYYLRRA DDTLIMTHLA GEPSTTTRKQ PTFAYPYLAH
MHVTLSGGTV TWQNNMDQCT SSVALKSDTF PLADPVFGTM NVLMPEQHLK CHIILDRQLA
SSVFGSWGPE PAAIKSTEGA ESEDIQVTGT QTQSRTNPRR IKPVTGRSSS LGLAGPAGGM
PLFRAVGTAA ASVGMPLIGR AHLPSWLQTS SSTKTIEISN PIPITSSAES ANGGMKPKDA
RLVSSQTTPK ATSTDSSKKV SRSSRGWFHQ AWHPMRRVAT ASDDPCAHSR TSKMTSAARR
FASTHGILTH SKSTTASQSD IMPSQLEHFG QIETEPPSLD VRSAVEPISS PAPLRLAACV
SPTPALQSPY VTYLSPEASD FPNGSRSSPM PSTSSHEDIL KAPTMVFTGS SSDIDSGMLS
EHSAVASITG QVHHVMIASE TFGTTPAFVP LPQPLSGPLP LHKCPRSTLS PFVPFIVELC
VTLVERYGLN CVGLYRLSGS KTAHDFISLE LRKPLQEIDI QSDKWNDIHA ICGVLKTFLR
TLPDSLFPKV MYTDFLNACR IPDREKRLLS IQRLLGIMEC YPDHPEYRAH RATLRYLATH
LARVSARETV NKMTIYNLAL VFAPNLVQPR EETPELLMSD SKYKIMLVET VIKYHSWIFS
PDLGIESGCS IPTDSVEELP SAITDLETTM MRGSTECGPL LIPTNSMEGE ESANQPGRVE
GDVQPLLAKL LNAAAGLPPP PSGTDLETAV EPGPESDRPS DIALPIHRRR FTSIPTSTWS
AAALRSLDPD ASIEGRRFQP ELLLTQETEF DAASEPSDND PSCDITPLTD LSPRPRQFSS
QLGTKLDNLR HLSQGCLDQY TNEARQLGER VAESRRQLQI IVTQRLHAEQ LLHEARNQRG
DQTAGSDLGS PNQSTPSTNV QDFTYLDTQE EQQPSESATV VQAITIRLIL HLDFHLVLPL
CQCCVSLT
//
