ID   A0A074ZKZ8_9TREM        Unreviewed;       616 AA.
AC   A0A074ZKZ8;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Tyrosine--tRNA ligase {ECO:0000256|ARBA:ARBA00013160, ECO:0000256|RuleBase:RU361234};
DE            EC=6.1.1.1 {ECO:0000256|ARBA:ARBA00013160, ECO:0000256|RuleBase:RU361234};
DE   AltName: Full=Tyrosyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00033323, ECO:0000256|RuleBase:RU361234};
GN   ORFNames=T265_05270 {ECO:0000313|EMBL:KER27711.1};
OS   Opisthorchis viverrini.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Opisthorchis.
OX   NCBI_TaxID=6198 {ECO:0000313|EMBL:KER27711.1, ECO:0000313|Proteomes:UP000054324};
RN   [1] {ECO:0000313|EMBL:KER27711.1, ECO:0000313|Proteomes:UP000054324}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Young N.D., Nagarajan N., Lin S.J., Korhonen P.K., Jex A.R., Hall R.S.,
RA   Safavi-Hemami H., Kaewkong W., Bertrand D., Gao S., Seet Q., Wongkham S.,
RA   Teh B.T., Wongkham C., Intapan P.M., Maleewong W., Yang X., Hu M., Wang Z.,
RA   Hofmann A., Sternberg P.W., Tan P., Wang J., Gasser R.B.;
RT   "Opisthorchis viverrini - life in the bile duct.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-
CC         tyrosyl-tRNA(Tyr); Xref=Rhea:RHEA:10220, Rhea:RHEA-COMP:9706,
CC         Rhea:RHEA-COMP:9707, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:58315, ChEBI:CHEBI:78442,
CC         ChEBI:CHEBI:78536, ChEBI:CHEBI:456215; EC=6.1.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000069,
CC         ECO:0000256|RuleBase:RU361234};
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000256|RuleBase:RU361234}.
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DR   EMBL; KL596716; KER27711.1; -; Genomic_DNA.
DR   RefSeq; XP_009168509.1; XM_009170245.1.
DR   AlphaFoldDB; A0A074ZKZ8; -.
DR   STRING; 6198.A0A074ZKZ8; -.
DR   GeneID; 20319452; -.
DR   KEGG; ovi:T265_05270; -.
DR   CTD; 20319452; -.
DR   OrthoDB; 6875at2759; -.
DR   Proteomes; UP000054324; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004831; F:tyrosine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006437; P:tyrosyl-tRNA aminoacylation; IEA:InterPro.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   Gene3D; 1.10.240.10; Tyrosyl-Transfer RNA Synthetase; 1.
DR   InterPro; IPR002305; aa-tRNA-synth_Ic.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR002307; Tyr-tRNA-ligase.
DR   InterPro; IPR024088; Tyr-tRNA-ligase_bac-type.
DR   NCBIfam; TIGR00234; tyrS; 1.
DR   PANTHER; PTHR11766:SF0; TYROSINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11766; TYROSYL-TRNA SYNTHETASE; 1.
DR   Pfam; PF00579; tRNA-synt_1b; 1.
DR   PRINTS; PR01040; TRNASYNTHTYR.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW   ECO:0000256|RuleBase:RU361234};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU361234};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU361234};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU361234};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|RuleBase:RU361234};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054324}.
SQ   SEQUENCE   616 AA;  68508 MW;  5B93A338C9491DF4 CRC64;
     MLGGVSKFLS TDASEALLVL DGVSDFAATG SIARNDPRSM SLAFMLVVEQ VLGRWGNLHV
     LGSCLGSNSS GSVHLMVPLE LRLNNNNNNN DSMTSVFNTD ASLPYSHDLF ESLIVKKRIK
     VRIQTFETNV SEKYLPDLPP NYSVYLGIDP SADSLQLGNL VALMGLLRCH MVGASVLTVV
     CILFLVIFNL EVGTGTVAVG DPSGRLTKRD SNPNLNYGTN ADEIEHELAN IRRNYLENFF
     PRKTETGAPH PIVILRNGDW LSDMHCLEFL RDITSHFRIP ELLEKESVQL RLNSGNGMDL
     NEFLYPTLQA VDFLHLYQKY NCRIQVGGQD QLGNIQCGLD LIHRMLGSYA FGLTVPLLTT
     PEGKKFGKSE TGAGTRSAPI WLSKDKLTPY GFYQRILNLP DQLIASRLLR QLTFFSSDEI
     QSLMKAHEDT PDTRPVQRAL ARELTLLVHG ASALHASELA TRIFFPRRKS TEQTSLGVIS
     EELTQQECDC LRTYLAPTVK LVPVIHSQLP VDWSIESVSR WLGCLLRTAT SADSESSYVT
     NCLRKGVTMN DVVLFKPNNA LKSVQHPSDD HLTVDLTVCQ LLQEAVGRCE ARLGLSILKL
     GKHEHWFVAT KRLWDT
//