ID A0A074ZXY5_9TREM Unreviewed; 4359 AA.
AC A0A074ZXY5;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
GN ORFNames=T265_01537 {ECO:0000313|EMBL:KER32308.1};
OS Opisthorchis viverrini.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Opisthorchis.
OX NCBI_TaxID=6198 {ECO:0000313|EMBL:KER32308.1, ECO:0000313|Proteomes:UP000054324};
RN [1] {ECO:0000313|EMBL:KER32308.1, ECO:0000313|Proteomes:UP000054324}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Young N.D., Nagarajan N., Lin S.J., Korhonen P.K., Jex A.R., Hall R.S.,
RA Safavi-Hemami H., Kaewkong W., Bertrand D., Gao S., Seet Q., Wongkham S.,
RA Teh B.T., Wongkham C., Intapan P.M., Maleewong W., Yang X., Hu M., Wang Z.,
RA Hofmann A., Sternberg P.W., Tan P., Wang J., Gasser R.B.;
RT "Opisthorchis viverrini - life in the bile duct.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; KL596635; KER32308.1; -; Genomic_DNA.
DR RefSeq; XP_009163860.1; XM_009165596.1.
DR STRING; 6198.A0A074ZXY5; -.
DR GeneID; 20315725; -.
DR KEGG; ovi:T265_01537; -.
DR CTD; 20315725; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000054324; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 2.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF34; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 3.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 2.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054324}.
FT DOMAIN 1481..1584
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1762..1920
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2107..2255
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 3573..3597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 417..444
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 893..927
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3020..3057
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4359 AA; 497736 MW; 2640466A7DADCCA8 CRC64;
MVHRDVDMRL LIDEKIKGRL CFRKPTIAQY KRTSVPARPF IEPLTQLKEY QEHNSVEAIH
SRAAAALTKR GSITPDDECK KKRLLSFATT KMDIPDSYIG TGSFVYKVPV IEAFTRGLEP
ANKQEKLLPN LVQLTHPHAL RFGKCEVSEM LDEVASYEGE TDILKIIQAL REKPAIKFFY
LTHALPKSST KYHYYNLKVA PFDKLNRNNY YTLSLHGCTH VVTNDETEHI SLERFETEYK
TFMNICKIPT FARFRLWKGF TRWRKVIRYM KMDQCRRHLR DNLYIANSSL RPALLNVREM
CYRISDMGLC KLEKGKTYTL LEFLTNQVNQ LNEVCTRLCE FRELVKEVVR SACRTALLEA
GFMPDDYFIE ANANPMVMER NLYDIEELVE GCKLSAKRLQ LEPIPYDIDH PLVGQAMKVV
NLSLRQIRNN RAKLERRTEK MKTQTQTLGT SYLSSGYDVE LFSEATDKMT FTEMAAKRKY
CQRLTCFIRL ADYQIVSTLH TLTVNSVYTL LDCLCDHLRH TPPVEEIASY QIKVNPLTEA
PNLASSVKRP DNYRVSVEEA AGKPQPAFSV NALTAESDGT QVTKPLFVLE FILEHDKLYM
IPDEPLFRDG ILEIISKFQE QVFGIKNLVP DPYFDAFTRP IINNKFEEKT CGSGPQLQHM
FAEDTGLKTI IENVKMSLSR AFEAVRAYMN TFKEIHDFYH ENNLITTEGI QQAQKQAFDS
MEHKDRLQTN MAFFRDNLLK HHREVLMTQL VPMQRSIGMF LIDTSTMRSL LLPSPNRCLE
LFHRLLPVDA RAEVDRLVQE TQEADYTLSL TPSTTVDFVK HLEFLVHMQT RIEPIEKEAD
VVKEIYDMIE SFSVPVPPED YAVYQTLLPS IERAKNSIDR ALSERDIIVD MFFASLDKDV
AEMLHDMKEA KQNINELVQT ISGTSLEDQI LSRASVRAAS LVEFLQKWFP NVLRMEQPRI
EELDLLVAEI KLKQLLWNSL EDWDEIYEQW LTADFLKLDT DELSATIQKY IKSVTMLEKG
LPPNNVVPLL KAKVDGMKSK LPSIMDMRNP TLQPRHWQKL EELIGFHLAE METPLSLGLL
IELDAFSHAE AILEVSSQAS SEASLEKLLK YLVYGELRSF LQRCVRHFCV AYFFHDECIL
LTLLIQVEDA WKSTEFTVLP YKDSKDIFIV GGTDEIQQLF DDSIINIATI ASSRHVGPIK
GRVEEWSALL DLFGKTLCYA IFIPKVGTAK VAKQFTRFLA DSILSLVDEP VYTNDILAML
SPEGERVALG KGLKARGNVE DWLGKVEEAM FANLKRLMKI SINSFDSSGR DEWLKSHANQ
IILTVEQLMW CRDITHILED PFPEDRLEGL EEFEKKCFAD LNQLAGMVRG ELPKLLRSLL
CALITIDVHA RDMVTELVAS KVDSLTNFDW QRQLRYYWDQ DQDICVVRMA SACYSYGYEY
LGASPRLVIT PLTDSTFSCK HSKYPGLFVR CYLCLMGALQ LDLGGAPAGP AGTGKTETTK
DLSKSVAKQC VVFNCSDGLD YKMMGRFFSG LAQSGAWCCF DEFNRIDIEV LSVIAQQLIT
IRNAKASKVS RFMFEGREIK LVPTCAAFIT MNPGYAGRTE LPDNLKSLFR PISMMVPDYR
LIAEVILYSE GFESSKTLAL KMTQMYKLCS EQLSQQDHYD FGMRALKSVL VMAGSLKRQN
PDKPEDVVLI RALRDSNLPK FLKQDSVLFT AILQDLFPGV TLPEHDYGRF MAEIEAVLTK
MGLQVVPAQV TKVIQFYETL LVRHGVMLVG PTGGGKTTVY RVLIKVLTNL HEAGLSSEVP
EYQPVKTYVL NPKAITMGEL YGEVNKLTLE WHDGLLASVV RKTCADTSED HQWVICDGPV
DALWIENMNT VLDDNKMLCL ANSERIKLTN YVHMLFEVQD LAVASPATVS RCGMVYVDSE
ELGWMPYVKT WLTGLLDKLT SPVVDYLMNL FVNYVDPCLE FVTTQCTDVI PQVPIARVQT
MCKLLEVLLT NPNAPSMTQE KHKLNPILAM SFVFSLIWGL AGGTIDANWD QVDAFVRNVF
DDVGDARLPQ HGDLWSCYVD MDTRRMDSWE KMLVSFTYKK EIPFFDMIVP TVDTVRYGYL
LDKLLEVDQS VLFTGLTGVG KSVVARGTLN NIAAARNYVP TFLNFSAQTS SNRTQEIIES
KLEKRKKGIR GAPKDKRVIL FVDDLNMPRL DTYGSQPPIE LLRQLKDFGG FYDRDKLEWI
TIQDVTLSAA CGPPGGGRNP VTPRLIRHFS VFTIPPPSEV NLKQIFSTIL KGFLREFPQG
VRGAVDAIIG AAVEIYVRMG KELLPTPAKS HYVFNLRDLS KCVQGILQAD PTVIRDKNAI
TRLFLHESLR VFHDRLISQE DKIFFYEMLV EMAGKYFGED MEVESFSKTP ILFGDFLKPG
LPRSERLYEE LTSTEKARTL LNEYLDEYNF SMSKEMKLVF FVDAIEHVCR IARMIRQDRG
NALLVGVGGT GKQSLTKLAA YINDYQCFQI ELTRGYDYQA FHEDLKKLYF WAGVENKPTV
FLFTDTQIVV EEFLEDINNI LNSGEVPNLF ENEEYERLII GCRPAAKEVG IPEGNRDAIF
DFCINRVRNN LHVVLCMSPV GSNFRVRCRM FPSLVNCCTI DWFVEWPEDA LYGVALSSFE
HVDLGSPEVK ECVARLSTEI HLSVSEAADR FYLELKRPYY TTPTSYLELL NLYLSMLATK
TNDVHFFSVV EQQSTTGVNV LFLLFYQILT YNFLSPLFHA LKRELSELRN KFRNGLDKIL
ETNELVVSME VELTAMRPTL EVKQRDTEKL MHKLGEDQEQ ADIVRTRVKE DEAIAKQKAQ
ETQAIADDAQ RDLDEAVPAL EAANKALDSL DKNDISEIRV FTKPPQLVQT VMEAVCLMLG
QKPDWATAKS LLGDSNFLRR LVEYPKDEIS DALLKKLKKY IDNPDFVPEV VEKTSKACKS
MCMWVRALDL YARLFRLVEP KRKRQVYSTP ILIAYTEKQT TGVIAWGRYG FRRNNWRHVG
APLRQLCCSL IIHFPSFPPS DRLEAANAEL DVVVQKLRQK QAELAAVERK IAILQSEFDV
SVAEKKKLEH RLALTTARLK RAAKLTTALA DEQDRWSLSV DQFQAQIANI VGDVFVAAAC
VAYYGAFTAD YRENLVNKWV ARCRELGIPV SEDPSLFNVL GNAFELRQWN TQGLPRDQIS
TDNAILVTRT RRWPLMIDPQ EQANRWIRTM EEENNLQVIK LTDMNLLRSL ETCIRLGYPM
LIEDVGETLD PALEPVLLRQ TFVSSGRLLI RLGDSDVDYD KNFHLYLTTK MANPHYLPEV
SIKVTLINFT VTPAGLEDQL LGDVTGIERP ELEEQRSQLI VRINTDRNQL KATEDRILKL
LFESEGNILD NEDLINTLNE SKVKSGEINK RLTEATSTEQ KITNARSKYS PVAARGSVMY
FVITTMAEID SMYQFSLKYF KNLFISTIQD SPESPILEER IQILLSTTTL ATYNSVARSL
FERDKLVFSF MLCAQIMRQQ GGITSPEWNY FLLGSGNLEW ARPPQPEETK GWLSAQQWRR
LVDLAHYFPE QFSSLPKDLI DGTIMLDFDP PTKDRMERRS SITSGREDNY LLTPNGPERR
ATRYNSELRS FQKLLLISNF SKEEVVRAVT DFIRSNLGPE FIEAPECSLS LLFKEMDRQT
PLVFILSPGS DPMGQLQRFA KEHGFADRIH SVSLGQGQGP AAEKLMEQAA RNGDWVFLQN
CHLAASWMIR LEELVKKRSD DPRPTNREFR LFLSSMPAKS FPISVLQNSV KVTNEPPKGL
RANLSRALNE LTAESFETHC RLHDTILPVE DMTQDHLLRL MEMEKNIGSM GIMAKYGLYR
ELGEGERDLA EACIPTEKSI NKHVDIDLVH QPLPTKESVL GETWRKLVFG ICFFHAIVLE
RKKFGPLGWN ISYDFNDSDR ECALLNLDMF CQDRGVPWDA LTYITSEITY GGRVTDFWDQ
RCLRTILERF FHPKTLEPTY TYSPSGIYYP PERQKLQDYK DYVLNLPLNA SPELFGMHEN
ANLVYQIQET NNLIATVLNI QPRTGAVGTG KTNDEIVHDL ANTILERIPD GLDLKIAKPE
FFLTDQKGRV DSLTTVMTQE VDRFNKLLHI VKDSLRQLQK AIKGFVVMSE GLEEVYTAFL
HNQIPKMWSA AAYPSLKPLS SWVTDLALRC DFINCWMSRG RPRSFWISGF FFPQGFLTGT
LQNYARKYDY PIDHLSFDFT VLPHYRDQEA VSKAMATLGF NQTLEADLAL NDPEDGVLIH
GLFMDGFRWD DERMELADSI LGETLAQMPV LHMKPEMDLK PDPKKYVAPL YKTSARAGVL
STTGMSTNFI VDISLKTSSS PKYWIERGAA LICERDVEN
//
