ID A0A075A119_9TREM Unreviewed; 1476 AA.
AC A0A075A119;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Upf1 domain-containing protein {ECO:0000259|PROSITE:PS51997};
GN ORFNames=T265_04125 {ECO:0000313|EMBL:KER29190.1};
OS Opisthorchis viverrini.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Opisthorchis.
OX NCBI_TaxID=6198 {ECO:0000313|EMBL:KER29190.1, ECO:0000313|Proteomes:UP000054324};
RN [1] {ECO:0000313|EMBL:KER29190.1, ECO:0000313|Proteomes:UP000054324}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Young N.D., Nagarajan N., Lin S.J., Korhonen P.K., Jex A.R., Hall R.S.,
RA Safavi-Hemami H., Kaewkong W., Bertrand D., Gao S., Seet Q., Wongkham S.,
RA Teh B.T., Wongkham C., Intapan P.M., Maleewong W., Yang X., Hu M., Wang Z.,
RA Hofmann A., Sternberg P.W., Tan P., Wang J., Gasser R.B.;
RT "Opisthorchis viverrini - life in the bile duct.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC {ECO:0000256|ARBA:ARBA00007913}.
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DR EMBL; KL596683; KER29190.1; -; Genomic_DNA.
DR RefSeq; XP_009167047.1; XM_009168783.1.
DR STRING; 6198.A0A075A119; -.
DR GeneID; 20318311; -.
DR KEGG; ovi:T265_04125; -.
DR CTD; 20318311; -.
DR OrthoDB; 170190at2759; -.
DR Proteomes; UP000054324; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR CDD; cd21407; 1B_UPF1-like; 1.
DR CDD; cd18039; DEXXQc_UPF1; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR CDD; cd21400; ZBD_UPF1-like; 1.
DR Gene3D; 2.40.30.230; -; 1.
DR Gene3D; 6.10.140.1240; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR040812; UPF1_1B_dom.
DR InterPro; IPR018999; UPF1_CH/ZBD.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF364; REGULATOR OF NONSENSE TRANSCRIPTS 1; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF18141; UPF1_1B_dom; 1.
DR Pfam; PF09416; UPF1_Zn_bind; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51997; UPF1_CH_RICH; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU01341}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054324};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU01341};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01341}.
FT DOMAIN 90..245
FT /note="Upf1"
FT /evidence="ECO:0000259|PROSITE:PS51997"
FT REGION 98..130
FT /note="C3H"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 112..140
FT /note="CC/SHH/C"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 158..188
FT /note="C4"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 1294..1327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1298..1327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1476 AA; 160919 MW; 335C3FA05C5EEC9E CRC64;
MDSFDAYGPN SQALTFFDPE ENDLIGGDTQ GPDFDCADFT LPSQSQTQAS QLDQERGGFA
QKNDINNRIN SLSQQILDLT TKDDDQDEAN SQLPEHACAY CGIHDPACVV YCNTTKKWFC
NGRGNTSGSH IVNHLVRARA KEVTLHKDGP LKDTLLECYV CGSKNVFLLG FVPAKSESVV
VLLCRNVCAN QNKDMYWDPA LWQPIIQNRQ FLSWLVKVPS EEAQAKARQI SAQQINRLEE
MWKENPQAAV EDLEKPGADR EVSPVLLRYK SSLQYQMTFK PLVEIEAAYD QKVKESLKLE
NVVVRWETAL NRKHVAYFRI PGANEGPELR IMHGDELIIR RFNTPDSNWS GVGHVIKIPD
NFSDEVGLEM KQADVVPSDP VTYMVEFKWK STPFDRMIQA ISKVTEEQCD LLPPYIFYRL
LGHEMDDMVL KCNLPKRYSA PDLPELNHSQ VFAVKTVLQR PLSLIQGPPG TGKTVTSASI
VYHLNKIHQK KVLVVAPSNT AVDQLCEKIS RTGLKVVRLC ARSREALASP VSHLMLHVQA
QHVKGHSELR KLQQLKDETG ELSQADEKRY RLLKRELERE LLVAADVVCC TCVTAGDQRL
ERLSFHSVLI DESTQATEPE CLIPLMVGCR QVVLVGDHCQ LGPVITCKKA ANAGLTQSLF
ERFVLLGIRP MRLQSSQNVD ITTLLLNTIE QDAEMTLRSP ATERQPEARH GYDRPVTCGF
KQLCTGNQLQ RFRKSDSYPD RKQSKPLTSC WHRAFPSNVF YEGSLQNGVT AEDRCKQIDF
PWPNPDRPMF FYCTSGQEEI SGNGVSYLNR TEAATVEKIV TKMLKIGVHP NTIGVITPYE
GQRAYLAHYL HYSGSLNSKL YQEIEIASVD AFQGREKDYI ILSCVRANEN QGIGFLNDPR
RLNVALTRAR YGLIVVGNPK ALCKAMPRKF VNNKFIVFSD FRDCESIQSS PKASVHNAVS
VRVTHSIHSV IVEIMRRALK DFRKLSVRIA SDENLVELEF ADDIVFVFEK GKEAQVFVDE
PTQAIPSIVE GPLNNLAEYM LQFPKPKVPY TFKPGGHFLS QLAANTALLN ANQMSQQRLG
PGGFFPQAGG NATQPSYPNP NDPNALLAAM AAAAAAYFGG GTSGNTSGLG GPGPSGGVSQ
PGASHAAAYA LAAAAAAQHH PNYHPSQGNP GSHSLHQLFD QIGYIGPNRQ FAAANANSSL
PMPMSMLMQT GQLHRASDLG MGNLYGSSAN TQTDTSKFAA AMGMNAFARP NGPGLNFGPS
LSQLGGSTRA PGGPLPTNQA TAGGISAPRY MGSGTRRAGQ VGNHSALAGS TKSRQPQQGL
DGLAGPGSST MTNMSTGLLS QPGLSELTGT QGAGGFGSMV GVYNSQSRNL GLSGLSQEST
SLDFRLGHGA SQVENFLLSQ DSTFQGATVS SGAQKFSARR NAELLNNGKG SVSNYDSGTR
LINGTDLGDL SLSQMVGGDP VADVGGGGGG APLSQF
//
