ID A0A075A183_9TREM Unreviewed; 1848 AA.
AC A0A075A183;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
DE Flags: Fragment;
GN ORFNames=T265_12870 {ECO:0000313|EMBL:KER32012.1};
OS Opisthorchis viverrini.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Opisthorchis.
OX NCBI_TaxID=6198 {ECO:0000313|EMBL:KER32012.1, ECO:0000313|Proteomes:UP000054324};
RN [1] {ECO:0000313|EMBL:KER32012.1, ECO:0000313|Proteomes:UP000054324}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Young N.D., Nagarajan N., Lin S.J., Korhonen P.K., Jex A.R., Hall R.S.,
RA Safavi-Hemami H., Kaewkong W., Bertrand D., Gao S., Seet Q., Wongkham S.,
RA Teh B.T., Wongkham C., Intapan P.M., Maleewong W., Yang X., Hu M., Wang Z.,
RA Hofmann A., Sternberg P.W., Tan P., Wang J., Gasser R.B.;
RT "Opisthorchis viverrini - life in the bile duct.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; KL596638; KER32012.1; -; Genomic_DNA.
DR RefSeq; XP_009164236.1; XM_009165972.1.
DR STRING; 6198.A0A075A183; -.
DR GeneID; 20327038; -.
DR KEGG; ovi:T265_12870; -.
DR CTD; 20327038; -.
DR OrthoDB; 1614410at2759; -.
DR Proteomes; UP000054324; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd00064; FU; 4.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR24416:SF566; EPIDERMAL GROWTH FACTOR RECEPTOR; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00261; FU; 6.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054324};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 984..1003
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1106..1431
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1139..1199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1465..1509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1685..1707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1807..1848
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1139..1163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KER32012.1"
SQ SEQUENCE 1848 AA; 204010 MW; CFC22CDEF5BC2302 CRC64;
VCRSGLQNIG GFPPNGSLDI LRRLFGNNCT HVIGNVVISD LATGENGVDP DLSFLEHIRE
ITGYLIIMYS NVETIPLTNL RVIRAEDGGY KIGADLQPAA LVIRHNHRNN VALRNIDLRN
LKSIVQGSVY VYDNPGLCYL SRRVNWTELF ETPGEQFVLG KEAVEAANEF TTTATPGHEK
WHGNDDYCDA AVCSYTCRNF TGGSQHCWGP DPEECQQESK CNNVDCNRCY SKQGKSICCH
EQCLGGCTGP EPTQCNACKE YIDSGTCVAH CPQNPVVKNG EMTQNPQFKY RLGALCVADC
PPGFLVESGA CVTHCTRPGT HAVGRNCLPC DGGRCPITCK LEYPLSHSGS EKQIINAVNL
RSLTNCTHLQ GNLVITNESF HINPSIPGHE PIRDIEELWA LHSLREIFGY VYLDLGSFGN
KLKNFSFLEN LVKVSGYHTN LKVSVTIINS GAEIVGLRRL REVPHGGVVL FNNTQLCYIQ
TLPWVVQNNG PENFEPPDLS RITGTMHIAV HESPDLETCT KRGAICHTSC DPRYGCWGPG
MDQCVRCLYY RAGEQNCVKS CDELPGFMYH PLGVRLKQYH SDVEIRRETE NRPAESYLRR
KSEIEHSFSM GLPDSDHICP PCHPECAHTC SGPGPDECIG DCKIAWAGGQ CVSQCDQFHY
LNGERRICEP CQIHCHQRRF TNQPVCTGPG RHPGPGGCNK CEKVIVTNPS KTDSQFDAQS
RMSLKLVCLR GDCPPGTYLT TEVIHPNSSF AHIAETFTNV LPVCRHCHPL CSECTAHSLV
EAGPDRMGCV VCSGVWFRGT CMEQCPIKET YTIDQTVYPK DPKVGETGFT GTIQARQLAG
RCLACHSACH MGCWGPEASQ CNHCLYVRVH LSIVPEVIRQ KEDRLEALFW SVTKQKASGW
NLAAEERLGP FMCSTTCPHG LNYSVTDPWS GDRLCYTSTE LSKADWTRIM HENSAFPIPA
QENIKMTKMA QPGGSKHSHV AITLFWIGLL GLCMLIPVIL YCIHRVRQPK KLRTAFTGFN
YFLPFSDCLP ILGQKNNRPS LLSDMSGPRP HGNPWRGDLM EMSPLCSEQT PVSKRDASTT
ESNANIQKAP NLGRLVMINS DDLILNEQCG PLGTGAFGAV YRGVWRIAEV DLGTRDEFTS
DSTIGNRPCS MQSSSTVCTT MPPTSDEGDE EHGSREGGGG ETPPSGSFGI QAKRHSANSS
TRYRMLPVAV KILNDGRGSS DLQALLDEAK VMASVSHKHC LPLIGVCLSK SRKCLVSAYV
MNGSLERYLR VHALDLPSAL LLDWAAQIAD GMCYLQSRGI IHREHLQITD FGLAKMLEGE
DEEKHGEVIV RSGRVPIRWL AIETLTHGRY SFKTDVWAYG VTLWEIFTFG EKPYERIETA
NVKAHILSGG RLPQPEICTL ELYQVMLRYA FAFDQVENLF FLLLIYSHYF LQTPRSIILE
DPYSSVGGDT RSRLTIYPSS MIFSERPDPA STSHMPSLRK DSASPSGMYR SGSINTNPAL
GSSSTGQQFD GRRRIRSSLL IQPTSLLYPG RFLKYQQQKR SSVGGRADNT TLSTSLSMAS
SGMSDRWSHS TFPHHSQPAL LGVKENTMPP TRGLPPAMFP RDTTHRQRAE IRATLNSDSW
ASSGQPLLSS DQDSSLSQLI LSNLGYTSSD SHSSMVINIP ATNTNTVPTS AVTIPSDVAN
QQITDASEDV TPSTSSPRSD NETIDPTIAS LNGLNSSMPA DFGLEAAAGY VWPQWPSVFS
ELNQTVPGDG SGTSNLPDSI NEDSLASLNR QLWLRRSAKQ RQFYRRQSQL HRHATLGMPL
PEQTIEEAME ESASWRHPGR DGGIFPSNQI DEEGSSAERY CPDPTGDN
//
