ID   A0A075ACY0_9TREM        Unreviewed;       966 AA.
AC   A0A075ACY0;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=RUN and TBC1 domain-containing protein 3 {ECO:0000256|ARBA:ARBA00030864};
GN   ORFNames=T265_06873 {ECO:0000313|EMBL:KER25699.1};
OS   Opisthorchis viverrini.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Opisthorchis.
OX   NCBI_TaxID=6198 {ECO:0000313|EMBL:KER25699.1, ECO:0000313|Proteomes:UP000054324};
RN   [1] {ECO:0000313|EMBL:KER25699.1, ECO:0000313|Proteomes:UP000054324}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Young N.D., Nagarajan N., Lin S.J., Korhonen P.K., Jex A.R., Hall R.S.,
RA   Safavi-Hemami H., Kaewkong W., Bertrand D., Gao S., Seet Q., Wongkham S.,
RA   Teh B.T., Wongkham C., Intapan P.M., Maleewong W., Yang X., Hu M., Wang Z.,
RA   Hofmann A., Sternberg P.W., Tan P., Wang J., Gasser R.B.;
RT   "Opisthorchis viverrini - life in the bile duct.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the small G protein signaling modulator family.
CC       {ECO:0000256|ARBA:ARBA00006296}.
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DR   EMBL; KL596768; KER25699.1; -; Genomic_DNA.
DR   RefSeq; XP_009170525.1; XM_009172261.1.
DR   AlphaFoldDB; A0A075ACY0; -.
DR   GeneID; 20321052; -.
DR   KEGG; ovi:T265_06873; -.
DR   CTD; 20321052; -.
DR   OrthoDB; 12479at2759; -.
DR   Proteomes; UP000054324; Unassembled WGS sequence.
DR   Gene3D; 1.20.58.900; -; 1.
DR   Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR   InterPro; IPR000195; Rab-GAP-TBC_dom.
DR   InterPro; IPR035969; Rab-GAP_TBC_sf.
DR   InterPro; IPR004012; Run_dom.
DR   InterPro; IPR037213; Run_dom_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR47219:SF20; GTPASE ACTIVATING PROTEIN GYP2; 1.
DR   PANTHER; PTHR47219; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   Pfam; PF02759; RUN; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00326; SH3; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR   PROSITE; PS50826; RUN; 1.
DR   PROSITE; PS50002; SH3; 1.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000054324};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          189..386
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000259|PROSITE:PS50086"
FT   DOMAIN          666..725
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          741..912
FT                   /note="RUN"
FT                   /evidence="ECO:0000259|PROSITE:PS50826"
FT   REGION          520..554
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        523..538
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        539..554
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   966 AA;  108556 MW;  7944CAF4AC76434A CRC64;
     MHELNAITPL TPRMVDTLAS REEDIGTARS IENIKSNGPF EVTQVVPFSA LIPSLRPSFS
     YFNKDVPQEE EENVANRSDT GTKRRFNEFG FSTPDFVDPP PVPFTESSAN RRAWITCLEF
     SHTHTLGVSS LDEYDSQYAF GDSATIDEEA DHLWSRVHPR LVPSPRLTAL IRGQAIDVLA
     TTKPGEQLGI PHSLRPHIWP RLTGSLEKSS IAKLRDPPLT YTELVQLSSS DTLAPGFQIE
     KDLFRTMPNN ACFSSSHSTG ISRLRRVLRS LAWLYVDVGY CQGMGLIAAN LLLCMEEETA
     FWMMCSIIED LLPPSYYSSI SLLGVQADQA VLCHLLPRYL PEVDCLLKDH GIELSLITLQ
     WFLTLYASVC PTPVTFRIWD LFFYEGSVVL FRIALALLTM KKPELMNLDN PVQIFNLLSG
     APGTVTDVNE LIQCTIAFAQ VAYSLDEEYL DASSVSSLRR HYLAQLMVEE SALLQPDSRP
     NLPKQYLAKR QLKRPRSALS QFLRAVALSS SPSRRLANVA VPFRDPQQQS SECHSPDYSR
     SSHNGEAEPE DPKLKNVRQT EILVELKQAI LMIVRHFRLC DPQHADASSQ ADYSMESHRL
     DLETYVQLQP LYDEYAVIAA DDDEVEKCGL SLDVAQWSRR KITEGLCFKP NLGIPITLLE
     AWVAQHRRRR AKALMDFERQ EPDELGFSKN DIITIVNSDD EHCWVGELEG VRGWFPANFV
     ELLDERGKNY SSAGDDAVNQ NIASLVRGGL CTALSAVFTH GLRRPRLLGE SGCHPWHFIE
     EAAAKEVERD FASVYSRLVL CKTFRLDEEG KVLSPEEVLY RAIHSINMSH DLAQAHMDVK
     FRSLVCYGLK VLSQFAFHLS PIYELATNRL DTASETNSKT ASSRRPTRSM VTVNSLVDAA
     GAKPLRRLTK AAVAKDPMND PPSLVSSFLS NTSTQDDSKE LERTYRMVAG NTGDMLVKYH
     LFSWEL
//