ID A0A075AD77_9TREM Unreviewed; 1000 AA.
AC A0A075AD77;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Peptidase M28 domain-containing protein {ECO:0000259|Pfam:PF04389};
GN ORFNames=T265_06749 {ECO:0000313|EMBL:KER25894.1};
OS Opisthorchis viverrini.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Opisthorchis.
OX NCBI_TaxID=6198 {ECO:0000313|EMBL:KER25894.1, ECO:0000313|Proteomes:UP000054324};
RN [1] {ECO:0000313|EMBL:KER25894.1, ECO:0000313|Proteomes:UP000054324}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Young N.D., Nagarajan N., Lin S.J., Korhonen P.K., Jex A.R., Hall R.S.,
RA Safavi-Hemami H., Kaewkong W., Bertrand D., Gao S., Seet Q., Wongkham S.,
RA Teh B.T., Wongkham C., Intapan P.M., Maleewong W., Yang X., Hu M., Wang Z.,
RA Hofmann A., Sternberg P.W., Tan P., Wang J., Gasser R.B.;
RT "Opisthorchis viverrini - life in the bile duct.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the peptidase M28 family.
CC {ECO:0000256|ARBA:ARBA00010918}.
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DR EMBL; KL596763; KER25894.1; -; Genomic_DNA.
DR RefSeq; XP_009170358.1; XM_009172094.1.
DR AlphaFoldDB; A0A075AD77; -.
DR STRING; 6198.A0A075AD77; -.
DR GeneID; 20320928; -.
DR KEGG; ovi:T265_06749; -.
DR CTD; 20320928; -.
DR OrthoDB; 277019at2759; -.
DR Proteomes; UP000054324; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008235; F:metalloexopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd03875; M28_Fxna_like; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR048024; Fxna-like_M28_dom.
DR InterPro; IPR045175; M28_fam.
DR InterPro; IPR007484; Peptidase_M28.
DR PANTHER; PTHR12147:SF26; ENDOPLASMIC RETICULUM METALLOPEPTIDASE 1; 1.
DR PANTHER; PTHR12147; METALLOPEPTIDASE M28 FAMILY MEMBER; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000054324};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 437..455
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 461..494
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 506..525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 655..675
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 175..360
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1000 AA; 111577 MW; DFD131E7AA519EEF CRC64;
MDARRRSSTS PGGGGANATT DPDNQSSASI DLKSHSSYDE GDTPIPLSFW LKSISLFFLL
TLMSSSVYRP CLSSTDRNVT PAPHQFIGAN ARRHLQKVTF LGSRTSGSLA NEVLAPEYLL
SELYDIARLG KSNGADIFVD EQLSSAASFR TGYAVQSYKN VKNLLIRFHN SSLSNHTTAF
LVNCHYDSFL GSPGATDTFV NCAILLEAGR AIATGKVQLV NDLIFLFNGA EESGLLTSHA
FVTQHRWSND VKSFLNLEGT GAGGRLFVFQ SSSDESSQLL LGTYESCFHY PYADVFGEEI
FQSGLIPSDT DFRIFRDFGF VPGLDMAYVR DGYAYHTPFD TEARISEECL QQNGEEILRF
LSAVGGDKRL ESVSKLKSVN DTGLPSSGPP LNELSSTKIS RSQLPKPKVQ TSAHHRHVYF
DILGIKLFVV SWTRWKLFNW FISLLVCCRL CFIRGSLPSR WVGLGISLVL HCLSQALGLI
FSLLLGFVVH SFGFRMSWYS NQYNVVGLYI LPLLCWFICY STWFFHTLHR HNGLLRKICA
YAKWSVTGDR RWNYALIEAD FFDAATLLLT VLVSVLTVLD RPAVFLFTLW LTSTVLGRFT
YKFIFSGSTF SSLSNFLLTL MPTLTLWHVY FSRTILEFFI PVFGRSGHLV RQDVLMSGFV
FFCVAPVALF ILGPLHCSST NCGKTLRLLF LNACVTYAVL VHSSSYGFPY TFTTGGNIND
SSVSPRFQRL SVFHIDRTFH GSLGSKELEG QESFITILAW DGNGIQYLKP QTGLKFLDDN
ENGKPNGLRE LLEATPAYCN FSLPYCGIPF FRPLFHFFTD FYHIPAKQHG SKPVAQLDVI
SRIPLASSQL QSGRVAWNFT FSLRPGPPQT PLALRFDVPH VRLLNWSFAV DTSVPVPVPL
TKSPSDPHVE SVGAHYFLDF IDARASISLP VEPWVFWLVI DRPSDMESSH FDIAVMGTYL
DTKLPSCVSA QLDDVVSRLP PWISLSSGCA SYDHYRVGLS
//