ID A0A075AT29_ROZAC Unreviewed; 1067 AA.
AC A0A075AT29;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Actin-binding FH2 domain-containing protein {ECO:0000313|EMBL:EPZ31653.1};
GN ORFNames=O9G_000132 {ECO:0000313|EMBL:EPZ31653.1};
OS Rozella allomycis (strain CSF55).
OC Eukaryota; Fungi; Fungi incertae sedis; Cryptomycota;
OC Cryptomycota incertae sedis; Rozella.
OX NCBI_TaxID=988480 {ECO:0000313|EMBL:EPZ31653.1, ECO:0000313|Proteomes:UP000030755};
RN [1] {ECO:0000313|EMBL:EPZ31653.1, ECO:0000313|Proteomes:UP000030755}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CSF55 {ECO:0000313|EMBL:EPZ31653.1,
RC ECO:0000313|Proteomes:UP000030755};
RX PubMed=23932404; DOI=10.1016/j.cub.2013.06.057;
RA James T.Y., Pelin A., Bonen L., Ahrendt S., Sain D., Corradi N.,
RA Stajich J.E.;
RT "Shared signatures of parasitism and phylogenomics unite Cryptomycota and
RT microsporidia.";
RL Curr. Biol. 23:1548-1553(2013).
CC -!- SIMILARITY: Belongs to the formin homology family. Diaphanous
CC subfamily. {ECO:0000256|ARBA:ARBA00008214}.
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DR EMBL; KE561209; EPZ31653.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A075AT29; -.
DR STRING; 988480.A0A075AT29; -.
DR EnsemblFungi; EPZ31653; EPZ31653; O9G_000132.
DR HOGENOM; CLU_002356_1_0_1; -.
DR OMA; MMPGFSP; -.
DR OrthoDB; 1331417at2759; -.
DR Proteomes; UP000030755; Unassembled WGS sequence.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.20.58.630; -; 1.
DR Gene3D; 6.10.30.50; -; 1.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014767; DAD_dom.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45691; PROTEIN DIAPHANOUS; 1.
DR PANTHER; PTHR45691:SF6; PROTEIN DIAPHANOUS; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51231; DAD; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000030755}.
FT DOMAIN 36..386
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 592..999
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT DOMAIN 1010..1038
FT /note="DAD"
FT /evidence="ECO:0000259|PROSITE:PS51231"
FT REGION 506..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1031..1051
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 918..952
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 507..563
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1067 AA; 121139 MW; DA7D0D64A37DBEE9 CRC64;
MGHKFSKASK QKLKVASTNS LNSFGTGSKF QASPVEPMPP IEELESEFGQ FLKELALPQE
KFEAMSQFDV NKKWMIVQQE RAKKKMQTAN VKSDIRTPGQ FVDLLKSYSF TTDFAKDLQT
LEVLMRTEAI SWVKEFISKG GVLEFYDMVQ RECQHQMIRI LKALMNNSNG LNVMMTTKRA
VNILCLCLDC DNLKIKAIVL QLLAAVCFVP NGHVKVLEGM HEFSLIKKEK TRFMNIVTDM
WRDDIEYQIA CMIFINAIVN IVEDATFRLN LRQEFISLGL NDHLERLGKL KDESLVTQLT
YFMDEDIEDK KVIGLEYNIN ELDISTIDKV INLIETNFKE PYQLSLVHQI LIQILLLPFE
NNDRTFYLTI GLSFLKDLVY QSQGKESNGV PSFHFDTNAL LTEIKLIEKN KTEQAQAKKE
KKQLPKTPCK IQVKGRFIEI PSELNSEETL NFIKPLVEKI LSEEDAKNSN KSPPQIETSI
TLDIPLPPLN TPSIPQANTN VASELKTIPP PPEPPMSSSI PPPPLMPLTP GVSVVPPNDS
SIPPPPPPPM APGMPPPPPP MMPGIPPPPM TPGMPPPPGM PSIGVAKMGL PNKKKVVPSI
KMKPLQWNKV PNSNVEKTIW KSMDAEEKIR KMIDLKEFEL SFGATVTSPV SPVGNAGKVD
EVEKKKSVSV LEPKRAYNLC KEYFEIKLAI MLSRIKMTFP EVKEAILRVD EEKITEQMIK
QFLNFIPTQE ETGLLMEYEN SSEQLEKADQ FFIQMIKIPR YEQRLNCILY KFRFQERYKE
LKPDLDAVIN ASNEVMKSKM FSQILEIILT LGNYMNGDSF RGGAYGFSID TLNKLNDTRS
SNGKGTFLHY LVNLLETKFS NTLDFPKELS NVEAACRVSI SSVMQEVSEM VKGMKQIESE
IETLNESSSE EDCFHKVFKN FHQSNENKIK ELENLKQEME NSFQKCVEYF NEDPKSSTPE
TFFPFFWNFI QNKTRKELAL NAKKVELKKS RSKLSVNGNS NTNLNASMEE DRRGVMDELI
SSLRTGDAFK AKSKRRRTVN SKDNPNASST DMLALNATEL LATIQND
//
