ID   A0A075ATW6_ROZAC        Unreviewed;      3901 AA.
AC   A0A075ATW6;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0000256|ARBA:ARBA00022197};
DE   AltName: Full=Dynein heavy chain, cytosolic {ECO:0000256|ARBA:ARBA00033439};
GN   ORFNames=O9G_003289 {ECO:0000313|EMBL:EPZ32150.1};
OS   Rozella allomycis (strain CSF55).
OC   Eukaryota; Fungi; Fungi incertae sedis; Cryptomycota;
OC   Cryptomycota incertae sedis; Rozella.
OX   NCBI_TaxID=988480 {ECO:0000313|EMBL:EPZ32150.1, ECO:0000313|Proteomes:UP000030755};
RN   [1] {ECO:0000313|EMBL:EPZ32150.1, ECO:0000313|Proteomes:UP000030755}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CSF55 {ECO:0000313|EMBL:EPZ32150.1,
RC   ECO:0000313|Proteomes:UP000030755};
RX   PubMed=23932404; DOI=10.1016/j.cub.2013.06.057;
RA   James T.Y., Pelin A., Bonen L., Ahrendt S., Sain D., Corradi N.,
RA   Stajich J.E.;
RT   "Shared signatures of parasitism and phylogenomics unite Cryptomycota and
RT   microsporidia.";
RL   Curr. Biol. 23:1548-1553(2013).
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DR   EMBL; KE561174; EPZ32150.1; -; Genomic_DNA.
DR   STRING; 988480.A0A075ATW6; -.
DR   EnsemblFungi; EPZ32150; EPZ32150; O9G_003289.
DR   HOGENOM; CLU_000038_0_0_1; -.
DR   OMA; CIEWQRY; -.
DR   OrthoDB; 166463at2759; -.
DR   Proteomes; UP000030755; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   Gene3D; 1.10.287.2620; -; 1.
DR   Gene3D; 1.10.472.130; -; 1.
DR   Gene3D; 1.10.8.1220; -; 1.
DR   Gene3D; 1.10.8.710; -; 1.
DR   Gene3D; 1.20.1270.280; -; 1.
DR   Gene3D; 1.20.58.1120; -; 1.
DR   Gene3D; 1.20.920.20; -; 1.
DR   Gene3D; 1.20.920.30; -; 1.
DR   Gene3D; 3.10.490.20; -; 1.
DR   Gene3D; 6.10.140.1060; -; 1.
DR   Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR   Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR035699; AAA_6.
DR   InterPro; IPR035706; AAA_9.
DR   InterPro; IPR041658; AAA_lid_11.
DR   InterPro; IPR042219; AAA_lid_11_sf.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR041589; DNAH3_AAA_lid_1.
DR   InterPro; IPR042222; Dynein_2_N.
DR   InterPro; IPR043157; Dynein_AAA1S.
DR   InterPro; IPR041466; Dynein_AAA5_ext.
DR   InterPro; IPR041228; Dynein_C.
DR   InterPro; IPR043160; Dynein_C_barrel.
DR   InterPro; IPR024743; Dynein_HC_stalk.
DR   InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR   InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR   InterPro; IPR013602; Dynein_heavy_linker.
DR   InterPro; IPR042228; Dynein_linker_3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR   PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR   Pfam; PF12774; AAA_6; 1.
DR   Pfam; PF12775; AAA_7; 1.
DR   Pfam; PF12780; AAA_8; 1.
DR   Pfam; PF12781; AAA_9; 1.
DR   Pfam; PF17857; AAA_lid_1; 1.
DR   Pfam; PF18198; AAA_lid_11; 1.
DR   Pfam; PF08393; DHC_N2; 1.
DR   Pfam; PF17852; Dynein_AAA_lid; 1.
DR   Pfam; PF18199; Dynein_C; 1.
DR   Pfam; PF03028; Dynein_heavy; 1.
DR   Pfam; PF12777; MT; 1.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Dynein {ECO:0000256|ARBA:ARBA00023017};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030755}.
FT   DOMAIN          1234..1372
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          1864..2010
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   COILED          587..636
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2469..2503
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2726..2760
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   3901 AA;  445777 MW;  3C27D3BFE20BC7D1 CRC64;
     MKPPLRLPSI KAKYGDEEPL TDDQRYQKTF KHIFVETVVE KKNKNIKFPK NIEEPQLLDP
     TLFISNEDEK LIKAIDSAAN KTKEDELRAS TNFFIHSIRR NIKVNFPDTA KKGILKYISK
     ELLTDHPLLA NTLLDEIKDE YIESETQSAL KFVLKNPNVN TEQHVQSLFY VKEHVPTLPA
     PWHESFVANK KRLEGHLMIG HPAMIRILEL SGVVDHIRLC DTHEILKSAQ KLRLTSFKSM
     VLVQSEVCRD RLVNGWLKTV IEILSSFFMP EKKNERAKNM RVFRCATAFV QIQIRSLILD
     SIDRYCSIFD DIEKNPHFFL KVFECENQIA CEPRIEDVEA AILESIDIML TTVDSLPSLY
     YSVSVKPNET EDTLSLVDED IKITINDDHV ENVKQILKEK MKFGHSSILK YFDTFESYKF
     LCSNGLQDEI AEFFKFSHSF EELSMQIEKY RNMPNEIYSN ARNVTIPLFH VNMEEYFKYL
     SDRAISISDQ FLSKMMQDSI VKQKGICKRF ENIQDRALRT PETFKEMADL MTFMEHVKNV
     ELPSLNEELE EAKRRFLYII NLGFLTEEIV ALNTVTFTWP MRLQPVLDRN EEILLSARRQ
     NEKLLEERRN KFLEELEELE SQVVELEKVE DFDEMQFYVK KVQGMMKQLV SAQETIAAFN
     KEEGLFGWPL TDYPKRNAII DKLEPYNQLY SAAVSFQKAN KKWMDGNFAE LDPQNIEDEL
     DSLRRETFKL ANILSDAPAP RNILAMTKQK IEEFSVNLPM IKILCNPGMR ERHWIKLSQI
     SNINLKPDAT ASLRKFLKMN LEKFIDSFQE VSDCASKEYS LEKALTKMKG EWDPILFVLK
     PYRETGTCVI AAVDDVQQLL DDQIVKTQAM RASPYSKPFE QDIKTWEQKL LLTQEIIDES
     LKVQATWLYL EPIFSSEDIM NQMPIEGKKF KQVDATRREV IKVLKVADIP ALLDELKGCN
     NFLEIILKGL NDYLDAKRLF FPRAFFLSND ELLNILSQSK DPRRVEPHLR KCFEGIASLD
     FDEQLQIGAA LSSEGERLQF ESKVTTADVK GAVEKWLLKV EAAMLANVRI VIEKALQAYK
     TTPREQWVLD WPGQVVLAVG QIFWTANVER AISGGGKKGL EELHARLTSE LNDVIKLVRG
     NISKMARMTL GALVVIDVHA KDVVYQLMQE GVKDVNDFSW LAQLRYYWEN NDVYVKMINS
     TVKYGYEYLG NTSRLVITPL TDRCYRTLFG ALQLNLGGAP EGPAGTGKTE TVKDLAKAIA
     KQCVVFNCSD GLDYLAMGKF FKGLAASGSW SCFDEFNRID SEVLSVVAQQ ILVIQRSVAA
     KLEKIVFEGT EINLKQGCAV FITMNPGYAG RSELPDNLKA LFRSVAMMVI VLEIVEKVPD
     YVLIAEITLY SYGFIEARNL ARKIVATYKL CSEQLSSQDH YDYGMRAVKS VLVAAGNLKQ
     KSGNLSEEII VLQSIIDVNL PKFLAQDAEL FKGITSDLFP GVKLPKLDYS LFDEALRSNC
     KKYNLEPTPY FLEKAIQVYE MMLVRHGFML VGEPAGKTSL YKVVANALTD LSNAGHEEYQ
     KVQYKIINPK SITLGQLYGQ FDPVSHEWQD GILSVTFRYF ASMNTPERKW CIFDGPVDAV
     WVENMNTVLD DNKKLCLMSG EIIQLTNTMS LIFETRDLSV ASPATISRCG MVYLDPESLG
     TEPMLKSWLS VLNIPNQSKE TLEHLIQYFV KDCVHFVKKN CKELCITSEL NLVKSFVNLM
     ETQLTDKTKV DLIGIYFKFV FAIVWSIAGC LDTESQKKFD EFFKTKLQKA VDDNLMHLMV
     LPKEDESCFN LVHKESQGSW MWRPWSSLID PSFNIPNNAK YSSITIPTKN TVRYSYLLKT
     LIENKKPCLI TGPTGTGKSK YIMNELMSLP TDQYDSTVIT FSARTSANQT QDIIMSKLDK
     RRKGVYGPPM GKTSLVFVDD LNMPTKERYG AQPPIELLRQ FIDHGYWYDR KEITKLELTD
     VLLLSALNPT GAYDKVTLRF LRHFNMLSVN PFDDQTMQTI FERILQWHFA GNGFVESLQM
     FVPKIVQATI EVHKRVCVNL LPTPEKTHYT FNLRDLGKVI QGMTFAKGSE YVSERGVMLL
     WLHEVYRIYN DRLINVGDRE WMFDQVKQVV VDVYNVRVEE IMETREVECS DLCGMMFDFV
     PDESGQKSYK VVRSQQGYLD MLSRQLEDYN NMNRNRMNLV LFRFALEHVA RIHRILKLPG
     GNALLVGLGG NGRSSLTRLA AFVAGYDLFT IELTKSYGKE NWNDDMKKMI MAAGVENKKC
     VFLFSDSQIK DESFIEDVNT LLNAGEIPNL LASDERANVI ERVRGDALSE GVSEVGGVYN
     YFVERVKQNL HIVLCMSPIG DSFRNRLRQF SSLVNCTTIN WFDSWPGDAL KAVAFRYFES
     VELEGGLKEK IIEMCRMFHE SLGVLSEKYM ANLKRHTYVT PTSFLELLLL YKNLLKKKRD
     EILEIKNRYD AGLEKLDFAA NQVERMKKEI RELQPQLKKT SEETSLMLSK IEVESKEIET
     TRKVVAAEEM IAEKKAKEAE AIKAECESNL AEALPLLNAA LSALDTLKKS DIDLVKAMKN
     PPSNVKLVME AVCVMKDLAP MRVPDPSGSG KMIADYWKTS LKMISDAHFL DSLKSYDKDN
     IPVHVVKKIR QTYLPDADFK PEKVRNASSA AEGLCNWIIA MEAYDRVAKI VGPKQEALKA
     AEQEYNETMV GLEAKRAVLR DVLERLGNLQ TSLEALTIKK QNLELQVGTC EKQLDRAEKL
     LGGLGGEKSR WTMVSQQLQT AYHNLTGDAL VSAGVISYLG PFTKSYRMNV IEEWIAAAKE
     KGIPTSAEFS LXGIPTSAEF SLGKVLGDAI QIKSWIMAGL PTDQFSIDNA IIVQNARRWP
     LMIDPQGQAN KWIKNMEKSN GLQVIKLTDG DYMRTLENAI QFGIPVLLEN VKEEIDPVLE
     PLLQKSTFKS GGVVCIKLGD NVIEYSKDFR LYITTKLSNP HYLPEISTKI SLLNFMITRE
     GLEDQLLGIV VAKERPELEE EKNQLILQST ENKKKLKEIE DKILEILSSV QGNILEDETA
     VNVLSSSKMI SNDLEEKQKI SEETEGKIDE TRESYRSIAE FSSVLFFCIA DLSSIDPMFV
     ELFISSILQS NRSNQVKKRL KNLEGHFLYS LYCNVCRSLF EKDKLLFSFL LSINILLNQK
     EIKMEEYQFL MTGGVGIETT DENPASWLSD KSWQQINKLS QLESFKSFKS DFKPNEWKPF
     YDSNEISHYP GKWNSLNEFQ KLLILRCLRP EKIIPSVQEF VKIKLGNKFI EPPTFDLASI
     FDDSNNRTPL IFILSPGVDP IASLIKFGQD KGFTNNKFQS VSLGQGQGPI ATQLIKTGLK
     EGNWVILQNC HLATSWMSTL EKICDDIQTA SVHKEFRLWL TCYPSQMFPA SILMNGIKMT
     NEPPKGLRAN ILRSYLSDPI ADENFFKKCK KHLEFEKLLY SLCFFHALVQ ERKTFGPLGW
     NIPYQFNESD LRISIRQLQM FLNEYDEIPF KALLYLTGEC NYGGRVTDDW DRRTLHSILS
     QFYNPQVLED QSYLYTLNQN YIVPPKGNYD SYLQFIRNLP LNASPDVFGI HENGEISKQL
     AETKSLFDSL LLTTENISSQ KNSASNLLEN VVSDILGKLT TPFNIDLVQR KFPISYNNSM
     NTVLVQEMIR YNKLISVIHS SLVNVEKALK GLIVMSSELE DICKSILMGK VPVQWASKSY
     PSLKPLGSYV NDLLKRITFL NAWFENGAPL VYWLPGFFFT QSFITGALQN YARKYTIPID
     ELSLDFELVY NVTEPPTDGV YVNGLFLEGA RWSKTKHCLA ESYPKELYDA LPTILFKPIK
     STELKPKSVY ECPVYKTSER KGTLSTTGHS TNYVLTLRLP TDKQEKHWVN AGVAALLQLD
     D
//