ID A0A075AY97_ROZAC Unreviewed; 4458 AA.
AC A0A075AY97;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0000256|ARBA:ARBA00022197};
DE AltName: Full=Dynein heavy chain, cytosolic {ECO:0000256|ARBA:ARBA00033439};
GN ORFNames=O9G_000452 {ECO:0000313|EMBL:EPZ33677.1};
OS Rozella allomycis (strain CSF55).
OC Eukaryota; Fungi; Fungi incertae sedis; Cryptomycota;
OC Cryptomycota incertae sedis; Rozella.
OX NCBI_TaxID=988480 {ECO:0000313|EMBL:EPZ33677.1, ECO:0000313|Proteomes:UP000030755};
RN [1] {ECO:0000313|EMBL:EPZ33677.1, ECO:0000313|Proteomes:UP000030755}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CSF55 {ECO:0000313|EMBL:EPZ33677.1,
RC ECO:0000313|Proteomes:UP000030755};
RX PubMed=23932404; DOI=10.1016/j.cub.2013.06.057;
RA James T.Y., Pelin A., Bonen L., Ahrendt S., Sain D., Corradi N.,
RA Stajich J.E.;
RT "Shared signatures of parasitism and phylogenomics unite Cryptomycota and
RT microsporidia.";
RL Curr. Biol. 23:1548-1553(2013).
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DR EMBL; KE561047; EPZ33677.1; -; Genomic_DNA.
DR STRING; 988480.A0A075AY97; -.
DR EnsemblFungi; EPZ33677; EPZ33677; O9G_000452.
DR HOGENOM; CLU_000038_4_0_1; -.
DR OMA; ITMDAHG; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000030755; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF8; DYNEINS HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030755}.
FT DOMAIN 1844..1940
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2449..2599
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3041..3120
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3264..3312
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3562..3648
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4458 AA; 510187 MW; 1D1A6DA142DE21BB CRC64;
MSAEGKRSGS AEKKGEDNES GSNNVPVEAI PLDPRVDWFS ERVLTSLRLK TEKWKKMTTV
KESAEAIVQF MDQIDVPTLL FTVNAKEEIV PCTRFPEVLK KKSIYFMKKP KAPSPLVAPF
EQYLIWGEVP AAPLEFLATM LDEIYGPMLV NPKNLETWPQ VVAHDMNNHF HQLQSNVYVI
AGQTKGKTLL PIPQNIFNEA GEVVLEKNVL HTIESAVIEW THQIHIVVKS NSASLNEDSN
PGPMVEIEFW AAKFANLKSI SQQLNSEKIQ KVAKILEESN STYYPAFRGM CDKVSNALDE
AQDINTYLQA FKPHAERLNG VSEFAEIANV LPALFHVVGM VWKLSRHYSN PTRMQVLIHE
LCNDIIEQAR TFIQPEDLFK NPPEEASLKL KTVLRKVELF KFLYDDQCKK MVEIDKPWNF
DTRLIFFRMD GFYERIENIL ELFDTIAEFN RLEKIEIGGS KGKILSSQIV QIFTEFSLAL
ANLAKIKYDI LNLKTEEFDI DLKKFHRVIE DLDKRLGTVL CQAFDDCCGL IGCFKLLDTF
SGLLNREHIQ RDFENKYFDL LKMFGEEIGV VTGMFLRQRE NPPIHYNMPP IAGALTWTHE
LKDRLTKSME KLTTFTHPIL TSSEEAIIMR KKYQEVLEMM DQHEQGVYGH WSGNIVDDSE
ENLGKPLLFR DEKNLLKVNF DPKVVALLKE VKYFNALTVQ VPEKASNVYS KQEELREFQF
NLEFIVNQYN TIQTTMLQVE QPLIQSRLEA IDSQFEDALN RISWKSSEIG EYIKSIGISV
GNLANIQKNM KSNVDQIQKI MKRWNNAPLI ERKDTRKPLN VDERDNKLNA TYEQIRQDGE
NIHKLIQETL NILQVDPEGE AWKNYLIFVD NILLAGLQET VKTSLQYLLN NMDQEYLSNN
ELYSLFESKL ELGSNELIFT PPMEEEVSNG FMSIIQALLS DIYKINKLIK PVTGKDVDYM
IAVTASNELE EMRSRILDKV RQVLEKCHEY KETFDQFAYL WIENRQDFLK QFVKQLKQKF
VQDGSPEEDF VAPLYLDQFE QQIKKYEDIH KTVMSLEGDV TFYGWFKIDA KPLKQALNLV
VKKWSYTLSK YLSDETIKTL NELNSFIKST KKGLQVKPVE GDYSALVASM GLLLAVKHRS
SIDNLFEPLR KTVNLLKHHG VDTPEEVFKF LSDLPEEWSD VKKMAVAMRD YVAPLQAQEV
DSLQKKCNTF EYKMHLFREE FRNKAPFKFD VGIEKCYELI DQCHVDVLII ESEAAAMKSS
ADLFELVIPS FKQLGDCRRD IGMLKSLWDL ISMVTYLFNE WKSTLWNQID TDALEIRCRD
LMKELRKFDK EIKGWDAFNG LDQMVKDMIT SLRAVGELRS NAIRDRHWKQ LMKTTGVTFT
LTTDMKFQDL LSLQLHKYED DVKGIVDRAT KELSMEKVLG ELEKTWNVME FTYEVHDRTK
TPLLKSSEEL IEILEDNQVL LQNMMTSKYV AYFLETISKW QNILSTVDTV VTLWLEVQKT
WSHLENIFIG SEDIRTQLPE DTKRFDGIDS DYKKLMAEAS KTPKTIEVCL KPSLFETLES
LQGQLALCEK SLAEYLETKR LAFPRFYFIS SSDLLDILAR GNQPQAVAIH LPKLFDNLAG
LKFKGGADSK TAIGMFSKED EYVEFSEECE CVGPVEVWLN RVVDVMRKTL RHLMSEAVVT
YEEKPREQWL FDYPAQISLA GTQIWWTTEV NAAFARLEEG YENSLKDYYK KQVNQLTALI
TLIQGELTKG NRQMIMTICT LDVHARDIVA KLISEKADNA QCFNWQCQLR LKWDEEQTDC
IANICDASFR YSYEYLGNTP RLVVTPLTDR CYITLTQSIH LIMGGAPAGP AGTGKTETVK
DLGRALAIMV YVFNCSEQMD YKSIGNIFKG LSQSGTWGCF DEFNRIAVEV LSVVGTQVKS
IQDALRAKKK RFVFQGEEIS LCKTVSYYIT MNPGYAGRAE LPENLKALFR PCSMVVPDLQ
MICEIMLMAE GFLEASTLAR KFTTLYRLNR ELLSKQDHYD WGLRAIKSVL VVAGGLKRSE
PGVNEEHVLM RALRDFNLPK IVTDDLPVFN GLISDLFPKI DIPRKRNEQF EDDIRKATIE
SGLQTEENFI LKVVQLEELL AVRHCVFVLG NAGTGKSQVW KTLAKTYNNM GKKCVYSDLN
PKAVTTDELF GCINPATREW KDGLFSTIMR DMSSIPNTDP KWIVLDGDID PQWIESLNTV
MDDNKILTLA SNERIPLKPH MRLLFEISDL KYATPATVSR AGILYINPTD LGWSPYVQSW
LEKREDAAEK SNLTVLFDRY VNPCLDVIHS KRFKCAPVED FSMVQTLCSI LEALLTPKNT
PKGCDKEWFE IYFVFAAVWA FGGIMYADTM VDYRVEFSKW WNTEFKLVKF PPTGTVFDYY
VDNETKKFMP WADKVPSFTF DPEVPLQNVL VNTVETYRTK YLLDLLADNG KPVLLIGPAG
SGKTVLMQDK LAQYGEDRMI VNISFNFYTT SLSLQQVLEK PLEKKAGRNY GPPGQKKLIY
FLDDLNMPEV DKYGTAQPHT ILRQHLDYKH WYDRSKLTLK EIHNCQYVAC MNPTAGSFTI
TSRLQRHFST FSVNFPAMEC LTTIYNSILS QFLRGFGEKI NKSCDRLVNG IIALHKKVAS
VFLPTAVKFH YVFNLRDLSS IIQGILFAQT SVIKEPIDLI RLWLHESTRV YGDKLVNADD
RKALSAIQAE IIKKSFEEMD QKSVFAEPLV FSHFAGGLSE PKYMSIKDWA SYKKILEEAL
EQYQEANAAM DLVLFEDAMS HISRVSRILE SPRGNGLLIG VGGSGKQSLA RLAAFMSGKD
IFQITLKKGY SSADLKLDLA MLYQKTGIKK QGVVFLLTDS QIADERFLVL INDLLASGNI
PGLFPDEDYE NIINAMRNEV KALGLIDTRE ACWDLFIKTV RKNLKVVLCF SPVGSALRNR
CRKFPAIVNC TMIDWFSEWP QEALLSVAQR FIDNCDLVPQ ELKESVTKFM AFAHQSVNDV
SKKYLENDKR YNYTTPKSFL ELINLYKIML EKKSTELLSS MERLENGLAK LQSTASQVDD
LKAKLASQEV ELRAKNEEAN RLIERVAIDT EKVNKEKAIA DEEERKVDAF AKEVAEKQRQ
CAEDLRAAEP ALAAAEEALN TLNKANLTEL KSFGSPTDEI KNVVAAVIVL LSPPGKIAKD
RSWKAGKAIM AKVDQFLETL IKFDKENIDK SNLEALAPYL SDPNFNTEFI KTKSAAAAGL
CGWVINIVKY FEVYCDVEPK RKALEQANLD LSVAQNRLAE IQNKIMELNK NLSDLKAKFE
KATADKLRCE EEAKRTQETI ILANRLVGGL ASENVRWAIS VDKFKEQQKT LTGDVLLAAA
FLSYVGCFTK KYRTELITEK WLPFLNDPSN NIPMSSDIDA LKILTNDAEI AKWCNEGLPN
DRVSLENATI FVNCKRWPLI IDPQLQGIRW VKNREKNLRI VRLGQRGYLD VIEKAVSSGD
VVLLEDIGVN LDPVLDALIG RNTIKKGKYI KIGDKEVEYD SNFRLILQTR IANPHYPPEI
QAQTSLINFT VTIAGLEDQL LADVVNSERP ELERTKAELT KQQNEFKIKL TELEDSLLSR
LSAAEGNFLG DYALVENLET TKRTATEIEV KVEEAKKTEK KINETRELYR PVAARSSLLY
FLLNDLNQIN PMYQYSLNAF KVVFQAAINS AEKSEELKER VFALIDNITF SVFKYTTRGL
FERDKLIFVT QMTFSILKHQ NDIDLEQLDF LLRGPVILNV NSPVEWLNNN SWGMVKALSN
LDSLKILASD IENSSKRWKK YCEHESPENE KLPQEWKNKT ALEKLCIIRA LRPDRLTYAV
RNFVKEKMGT KYIDSTRVPL KISFQESSPG TPIFFILSPG VDPVKEVEEL GLSLNFTEDN
GKFYNISLGQ GQEVIAEQKL DLAYKDGGWV MLQNIHLTVK WLPTLEKKLE SLSQNSHPDF
RVFLSAEPSA DPAFHVIPTS ILQSSIKITN EPPTGMNANI HRALDNFKQE TLEMCSKESE
FKTILFSLCY FHAVVLERRK FGTQGWNKGY PFNTGDLTIS VNVLYNYLEA SVKVPWVDLR
YIFGEIMYGG HISDDWDRRL CSAYLETFVN EQLFEGAMEF APGFPVPPPS DYKEYHRYID
DQLPPETPYL YGLHPNAEID VLTKTADKLF KTILEMQPQE TAGGSVVSRE EKVKQILDDI
IERLPESFNT LEMIARVEER TPYISVAIQE CDRMAILTNE IRRSLKELDL GLKGDLTISE
NMESLMNAMF LNEVPESWKK MAYQSTYGLA QWYADLLTRI KELESWVSEF QLPSVVWLSG
LFNPQSFLTA IMQTTARKNE WPLDKMTLNV DVTKKTREEF NAPPREGAYI HGLFMEGARW
DTASGMIQES LLKELTPSMP VIYVKAVTID KKDTKGVYEC PLYTTKTRGP TFVWTFNLKT
KEKPQKWTLA GVALLLSI
//
