ID   A0A075B557_ROZAC        Unreviewed;       875 AA.
AC   A0A075B557;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=26S proteasome regulatory subunit RPN2 {ECO:0000256|PIRNR:PIRNR015947};
GN   ORFNames=O9G_005843 {ECO:0000313|EMBL:EPZ36768.1};
OS   Rozella allomycis (strain CSF55).
OC   Eukaryota; Fungi; Fungi incertae sedis; Cryptomycota;
OC   Cryptomycota incertae sedis; Rozella.
OX   NCBI_TaxID=988480 {ECO:0000313|EMBL:EPZ36768.1, ECO:0000313|Proteomes:UP000030755};
RN   [1] {ECO:0000313|EMBL:EPZ36768.1, ECO:0000313|Proteomes:UP000030755}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CSF55 {ECO:0000313|EMBL:EPZ36768.1,
RC   ECO:0000313|Proteomes:UP000030755};
RX   PubMed=23932404; DOI=10.1016/j.cub.2013.06.057;
RA   James T.Y., Pelin A., Bonen L., Ahrendt S., Sain D., Corradi N.,
RA   Stajich J.E.;
RT   "Shared signatures of parasitism and phylogenomics unite Cryptomycota and
RT   microsporidia.";
RL   Curr. Biol. 23:1548-1553(2013).
CC   -!- FUNCTION: Acts as a regulatory subunit of the 26S proteasome which is
CC       involved in the ATP-dependent degradation of ubiquitinated proteins.
CC       {ECO:0000256|PIRNR:PIRNR015947}.
CC   -!- SIMILARITY: Belongs to the proteasome subunit S1 family.
CC       {ECO:0000256|ARBA:ARBA00006308, ECO:0000256|PIRNR:PIRNR015947}.
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DR   EMBL; KE560450; EPZ36768.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A075B557; -.
DR   STRING; 988480.A0A075B557; -.
DR   EnsemblFungi; EPZ36768; EPZ36768; O9G_005843.
DR   HOGENOM; CLU_002323_0_0_1; -.
DR   OMA; IMFGRQE; -.
DR   OrthoDB; 151732at2759; -.
DR   Proteomes; UP000030755; Unassembled WGS sequence.
DR   GO; GO:0008540; C:proteasome regulatory particle, base subcomplex; IEA:UniProtKB-UniRule.
DR   GO; GO:0030234; F:enzyme regulator activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042176; P:regulation of protein catabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR016642; 26S_Psome_Rpn2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR002015; Proteasome/cyclosome_rpt.
DR   InterPro; IPR048570; PSMD1_RPN2_N.
DR   InterPro; IPR040623; RPN2_C.
DR   PANTHER; PTHR10943; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10943:SF2; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1; 1.
DR   Pfam; PF13646; HEAT_2; 1.
DR   Pfam; PF01851; PC_rep; 1.
DR   Pfam; PF18004; RPN2_C; 1.
DR   Pfam; PF21505; RPN2_N; 1.
DR   PIRSF; PIRSF015947; 26S_Psome_Rpn2; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Proteasome {ECO:0000256|ARBA:ARBA00022942, ECO:0000256|PIRNR:PIRNR015947};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030755};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          1..247
FT                   /note="26S proteasome non-ATPase regulatory subunit 1/RPN2
FT                   N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF21505"
FT   DOMAIN          683..848
FT                   /note="26S proteasome regulatory subunit RPN2 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF18004"
FT   REGION          855..875
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   875 AA;  98629 MW;  8524F097C79129AE CRC64;
     MYEDEKFSER ELAALVVSKV YFHLGAYDEA LMFAMSAGAN FEMGEGSEYS ETMILKGIDR
     YVRERREGRV DIDVRLVKIV ERMFDKCMRD GMWTHAVGIA VESLRFDVVE RAIEGSGDVE
     GMIEYVREIA MNYVEGLEVR NKMLEMCVEM YLKRKEANYE RVGECLISLG QPEKCARVLI
     ELSEGDEDKR LIGYQIGFNL YENASRVFLN ETINKIREIK GEETKMITIL NGDLTGQLYL
     EFLYRNNKTD LNILKEMQKY LEAKSSISMN GLMFSHAFMN AGTTDDTFLR NNVEWMQKAS
     LWSKFSVTAS LGVIHKGQVK EAFNILKPYL PQNGVAGSAY SEGGSLYALG LMSCGNYSEE
     SRKISEYLMN ALKNNHDETI KHGASLGIGL NMMGSGDMSV YEELKGIMYS DDAVSGEAAG
     ISIGLIMMGT GNEQVIEEMI EYGSETQHEK IMRGIAVGIG LIMYKQEEKA EKIIDRLKES
     KDPIMRYASV YVIGMSFVGS GNMKWIKHLL HVAVSDTSDD VRRVAIIFIG FLLYKNYEQV
     PKIIKLLSES FNPFVRFGST LALGISCAGS NFEEALNILD PLTRDNVDYV KQGAFIAIAM
     ICVQNNAKSK NYLNLFQKVI KNKYESPLSK FGASLASSIL NIGGRNSNIF LNSSFSFVGL
     SLFIHSWFWF PLNLCLSLSF NPTCFIGLNK DLVLPNFNFN SKKLFEYPEN IKNENKDLPD
     KIVTAILSTT AKAKARAHKK EKKIKGDESM KMDVEGVKEG VKEVVKEGDV EMKVDNEHVS
     NENVSNEHIS NENLTTSPLN LNAMNFTRIL PIQTQFISFD NSRFHPISKS KKSGIVLLKD
     KTPNQPFDQI KINIPLANND NDNEPSPPEP FEYVE
//