ID A0A075B6A0_MOUSE Unreviewed; 476 AA.
AC A0A075B6A0;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Immunoglobulin heavy constant mu {ECO:0000313|Ensembl:ENSMUSP00000136807.3};
DE Flags: Fragment;
GN Name=Ighm {ECO:0000313|Ensembl:ENSMUSP00000136807.3,
GN ECO:0000313|MGI:MGI:96448};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000136807.3, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000136807.3, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000136807.3,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000136807.3}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000136807.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR jPOST; A0A075B6A0; -.
DR ProteomicsDB; 310732; -.
DR Ensembl; ENSMUST00000177715.8; ENSMUSP00000136807.3; ENSMUSG00000076617.10.
DR AGR; MGI:96448; -.
DR MGI; MGI:96448; Ighm.
DR VEuPathDB; HostDB:ENSMUSG00000076617; -.
DR GeneTree; ENSGT00940000161491; -.
DR HOGENOM; CLU_030625_3_0_1; -.
DR OMA; CEVHSTE; -.
DR ChiTaRS; Ighm; mouse.
DR Proteomes; UP000000589; Chromosome 12.
DR Bgee; ENSMUSG00000076617; Expressed in spleen and 166 other cell types or tissues.
DR ExpressionAtlas; A0A075B6A0; baseline and differential.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0071757; C:hexameric IgM immunoglobulin complex; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0071756; C:pentameric IgM immunoglobulin complex; IEA:Ensembl.
DR GO; GO:0034987; F:immunoglobulin receptor binding; IEA:Ensembl.
DR GO; GO:0042834; F:peptidoglycan binding; IEA:Ensembl.
DR GO; GO:0031210; F:phosphatidylcholine binding; IEA:Ensembl.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0002250; P:adaptive immune response; IEA:Ensembl.
DR GO; GO:0019731; P:antibacterial humoral response; IEA:Ensembl.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl.
DR GO; GO:0045087; P:innate immune response; IEA:Ensembl.
DR CDD; cd21819; IgC1_CH1_IgM; 1.
DR CDD; cd05768; IgC1_CH3_IgAGD_CH4_IgAEM; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR PANTHER; PTHR23411:SF35; IMMUNOGLOBULIN HEAVY CONSTANT MU; 1.
DR PANTHER; PTHR23411; TAPASIN; 1.
DR Pfam; PF07654; C1-set; 4.
DR SMART; SM00407; IGc1; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50835; IG_LIKE; 4.
DR PROSITE; PS00290; IG_MHC; 3.
PE 1: Evidence at protein level;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|EPD:A0A075B6A0,
KW ECO:0007829|MaxQB:A0A075B6A0};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 449..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 6..105
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 112..213
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 220..321
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 331..432
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000136807.3"
SQ SEQUENCE 476 AA; 52610 MW; 6EA48FA493B00084 CRC64;
XSQSFPNVFP LVSCESPLSD KNLVAMGCLA RDFLPSTISF TWNYQNNTEV IQGIRTFPTL
RTGGKYLATS QVLLSPKSIL EGSDEYLVCK IHYGGKNKDL HVPIPAVAEM NPNVNVFVPP
RDGFSGPAPR KSKLICEATN FTPKPITVSW LKDGKLVESG FTTDPVTIEN KGSTPQTYKV
ISTLTISEID WLNLNVYTCR VDHRGLTFLK NVSSTCAASP STDILTFTIP PSFADIFLSK
SANLTCLVSN LATYETLNIS WASQSGEPLE TKIKIMESHP NGTFSAKGVA SVCVEDWNNR
KEFVCTVTHR DLPSPQKKFI SKPNEVHKHP PAVYLLPPAR EQLNLRESAT VTCLVKGFSP
ADISVQWLQR GQLLPQEKYV TSAPMPEPGA PGFYFTHSIL TVTEEEWNSG ETYTCVVGHE
ALPHLVTERT VDKSTEGEVN AEEEGFENLW TTASTFIVLF LLSLFYSTTV TLFKVK
//
