ID TRGV2_HUMAN Reviewed; 118 AA.
AC A0A075B6R0;
DT 16-JAN-2019, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=T cell receptor gamma variable 2 {ECO:0000303|Ref.2};
DE Flags: Precursor;
GN Name=TRGV2 {ECO:0000303|Ref.2};
GN Synonyms=TCRGV2 {ECO:0000312|HGNC:HGNC:12287};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (IMGT ALLELE TRGV2*03).
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2]
RP NOMENCLATURE.
RA Lefranc M.P., Lefranc G.;
RT "The T Cell Receptor FactsBook.";
RL (In) Lefranc M.P., Lefranc G. (eds.);
RL The T Cell Receptor FactsBook., pp.1-397, Academic Press, London. (2001).
RN [3]
RP REVIEW ON FUNCTION AND ANTIGEN RECOGNITION.
RX PubMed=23348415; DOI=10.1038/nri3384;
RA Vantourout P., Hayday A.;
RT "Six-of-the-best: unique contributions of gammadelta T cells to
RT immunology.";
RL Nat. Rev. Immunol. 13:88-100(2013).
RN [4]
RP REVIEW ON GAMMA DELTA T CELL RECEPTOR DIVERSITY.
RX PubMed=24387714; DOI=10.1146/annurev-immunol-032713-120216;
RA Chien Y.H., Meyer C., Bonneville M.;
RT "gammadelta T cells: first line of defense and beyond.";
RL Annu. Rev. Immunol. 32:121-155(2014).
RN [5]
RP NOMENCLATURE.
RX PubMed=24600447; DOI=10.3389/fimmu.2014.00022;
RA Lefranc M.P.;
RT "Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise
RT of Immunoinformatics.";
RL Front. Immunol. 5:22-22(2014).
RN [6]
RP REVIEW ON T CELL RECEPTOR SIGNALING, AND SUBUNIT.
RX PubMed=25674089; DOI=10.3389/fimmu.2015.00015;
RA Ribeiro S.T., Ribot J.C., Silva-Santos B.;
RT "Five Layers of Receptor Signaling in gammadelta T-Cell Differentiation and
RT Activation.";
RL Front. Immunol. 6:15-15(2015).
RN [7]
RP REVIEW ON FUNCTION.
RX PubMed=28920588; DOI=10.1038/nri.2017.101;
RA Nielsen M.M., Witherden D.A., Havran W.L.;
RT "gammadelta T cells in homeostasis and host defence of epithelial barrier
RT tissues.";
RL Nat. Rev. Immunol. 17:733-745(2017).
CC -!- FUNCTION: V region of the variable domain of T cell receptor (TR) gamma
CC chain that participates in the antigen recognition (PubMed:24600447).
CC Gamma-delta TRs recognize a variety of self and foreign non-peptide
CC antigens frequently expressed at the epithelial boundaries between the
CC host and external environment, including endogenous lipids presented by
CC MH-like protein CD1D and phosphoantigens presented by butyrophilin-like
CC molecule BTN3A1. Upon antigen recognition induces rapid, innate-like
CC immune responses involved in pathogen clearance and tissue repair
CC (PubMed:23348415, PubMed:28920588). Binding of gamma-delta TR complex
CC to antigen triggers phosphorylation of immunoreceptor tyrosine-based
CC activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases,
CC allowing the recruitment, phosphorylation, and activation of ZAP70 that
CC facilitates phosphorylation of the scaffolding proteins LCP2 and LAT.
CC This lead to the formation of a supramolecular signalosome that
CC recruits the phospholipase PLCG1, resulting in calcium mobilization and
CC ERK activation, ultimately leading to T cell expansion and
CC differentiation into effector cells (PubMed:25674089). Gamma-delta TRs
CC are produced through somatic rearrangement of a limited repertoire of
CC variable (V), diversity (D), and joining (J) genes. The potential
CC diversity of gamma-delta TRs is conferred by the unique ability to
CC rearrange (D) genes in tandem and to utilize all three reading frames.
CC The combinatorial diversity is considerably increased by the sequence
CC exonuclease trimming and random nucleotide (N) region additions which
CC occur during the V-(D)-J rearrangements (PubMed:24387714).
CC {ECO:0000303|PubMed:23348415, ECO:0000303|PubMed:24387714,
CC ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25674089,
CC ECO:0000303|PubMed:28920588}.
CC -!- SUBUNIT: Gamma-delta TR is a heterodimer composed of a gamma and delta
CC chain; disulfide-linked. The gamma-delta TR is associated with the
CC transmembrane signaling CD3 coreceptor proteins following the
CC stoichiometry: a single gamma-delta TR heterodimer associates with one
CC CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247
CC homodimer forming a stable octameric structure. Upon activation, gamma-
CC delta TR complex associates with FCER1G to initiate intracellular
CC signaling. {ECO:0000303|PubMed:25674089}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}.
CC -!- POLYMORPHISM: There are several alleles. The sequence shown is that of
CC IMGT allele TRGV2*03. {ECO:0000305}.
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DR EMBL; AC007245; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A075B6R0; -.
DR SMR; A0A075B6R0; -.
DR IMGT_GENE-DB; TRGV2; -.
DR BioMuta; TRGV2; -.
DR PeptideAtlas; A0A075B6R0; -.
DR Ensembl; ENST00000426402.2; ENSP00000404928.2; ENSG00000233306.2.
DR UCSC; uc064cyc.1; human.
DR AGR; HGNC:12287; -.
DR GeneCards; TRGV2; -.
DR HGNC; HGNC:12287; TRGV2.
DR HPA; ENSG00000233306; Tissue enriched (lymphoid).
DR neXtProt; NX_A0A075B6R0; -.
DR OpenTargets; ENSG00000233306; -.
DR VEuPathDB; HostDB:ENSG00000233306; -.
DR GeneTree; ENSGT00940000153143; -.
DR HOGENOM; CLU_077975_7_1_1; -.
DR InParanoid; A0A075B6R0; -.
DR OMA; ATWASHC; -.
DR PhylomeDB; A0A075B6R0; -.
DR SignaLink; A0A075B6R0; -.
DR PRO; PR:A0A075B6R0; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; A0A075B6R0; Protein.
DR Bgee; ENSG00000233306; Expressed in granulocyte and 83 other cell types or tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0042101; C:T cell receptor complex; IEA:UniProtKB-KW.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR19256:SF66; T CELL RECEPTOR GAMMA VARIABLE 2-RELATED; 1.
DR PANTHER; PTHR19256; T-CELL RECEPTOR GAMMA CHAIN; 1.
DR Pfam; PF07686; V-set; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW Adaptive immunity; Cell membrane; Disulfide bond; Immunity;
KW Immunoglobulin domain; Innate immunity; Membrane; Receptor;
KW Reference proteome; Signal; T cell receptor.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..118
FT /note="T cell receptor gamma variable 2"
FT /evidence="ECO:0000255"
FT /id="PRO_5001705911"
FT DOMAIN 18..>118
FT /note="Ig-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 41..113
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT NON_TER 118
SQ SEQUENCE 118 AA; 13310 MW; AAF29960A36B877F CRC64;
MQWALAVLLA FLSPASQKSS NLEGRTKSVI RQTGSSAEIT CDLAEGSNGY IHWYLHQEGK
APQRLQYYDS YNSKVVLESG VSPGKYYTYA STRNNLRLIL RNLIENDFGV YYCATWDG
//
