ID A0A075FDX8_9ADEN Unreviewed; 858 AA.
AC A0A075FDX8;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=DNA polymerase {ECO:0000256|PIRNR:PIRNR000788};
DE EC=2.7.7.7 {ECO:0000256|PIRNR:PIRNR000788};
OS Human adenovirus 55.
OC Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus B.
OX NCBI_TaxID=714978 {ECO:0000313|EMBL:AIE89120.1, ECO:0000313|Proteomes:UP000158851};
RN [1] {ECO:0000313|EMBL:AIE89153.1, ECO:0000313|Proteomes:UP000162444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hebei/BD6729/2013 {ECO:0000313|EMBL:AIE89153.1};
RA Liu W., Tong Y., Huang Y., Huang D., Xu X., Wang W., Lu Q., Fan H., An X.;
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AIE89120.1, ECO:0000313|Proteomes:UP000158851}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hebei/BD6728/2013 {ECO:0000313|EMBL:AIE89120.1};
RA Liu W., Tong Y., Huang D., Xu X., Wang W., Lu Q., Fan H., An X., Huang Y.;
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632,
CC ECO:0000256|PIRNR:PIRNR000788};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|PIRNR:PIRNR000788}.
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DR EMBL; KJ883520; AIE89120.1; -; Genomic_DNA.
DR EMBL; KJ883521; AIE89153.1; -; Genomic_DNA.
DR Proteomes; UP000158851; Genome.
DR Proteomes; UP000162444; Genome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR014382; DNA-dir_DNA_pol_B_adenovir.
DR InterPro; IPR004868; DNA-dir_DNA_pol_B_mt/vir.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR Pfam; PF03175; DNA_pol_B_2; 1.
DR PIRSF; PIRSF000788; DPol_ADV; 1.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|PIRNR:PIRNR000788};
KW DNA-binding {ECO:0000256|PIRNR:PIRNR000788};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|PIRNR:PIRNR000788};
KW Nucleotidyltransferase {ECO:0000256|PIRNR:PIRNR000788};
KW Transferase {ECO:0000256|PIRNR:PIRNR000788};
KW Viral DNA replication {ECO:0000256|ARBA:ARBA00023109}.
FT DOMAIN 368..850
FT /note="DNA-directed DNA polymerase family B
FT mitochondria/virus"
FT /evidence="ECO:0000259|Pfam:PF03175"
FT REGION 830..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 858 AA; 98832 MW; F0E6D197639C1583 CRC64;
MQEAREPPPI KRKNKGTVVA PKGHGTLQAI DVSTNEPVEI KYHLNLPHAL EKIMQVNLLS
LPTNLSPQRL RTLDSSSLRA LVLQLRPSRA EVWTCLPRGL VSMTTIETED EQANTANIEE
HEIQSPGLGF PLKFLVKGSQ VQLIHEIQPV QRCDYCGRLY KHKHECSARR RNFYFHHINS
QSSNWWQEIQ FFPIGSHPRT ERLFLTYDVE TYTWMGSFGK QLVPFMLVMK LSGEERLVNM
AHDLAIKLKW DRWQQDPETF YCVTPEKMAI GQHFRQYRDQ LQTALAVDLW SSFLHANPHL
HEWALEHYAL SDPTDLTFDE LNKLPHVRGT PRFIELYIVG HNINGFDEIV LAAQVINNRA
EVPQPFRITR NFMPRAGKIL FNDVTFALPN PAYKKRVDFQ LWEQGACDDM DFKYQFLKVM
VRDTFALTHA SLRKAAQAYS LPVEKGCCPY KAVNQFYMLG SYRADKDGFP LEEYWKDREE
YLLNRELWEK KNQPGYDIIQ ETLDYCALDV LVTAELVTKL EESYAHFIRD SVGLPHAHFN
IFQRPTISSN SHAIFRQIVY RTEKPNRTNL GPGLLAPSHE LYDYVRASIR GGRCYPTYIG
IFEDPIYVYD ICGMYASALT HPMPWGSPLN PYERALAARE WQMALDDPTP ISYFDKDLLP
GIFTMDADPP DELMLDPLPP FCSRKGGRLC WTNEPLRGEV ATSVDLITLH NRGWQVRIVP
DELTTIFPEW KCLAREYVQL NIAAKERADK EKNQTMRSIA KLLSNALYGS FATKLDNKKI
VFSDQMDENL MKGISSGTVN IKSSSFLETD NLSAEVMPAF EREYLPQQLT FLDSDPEDSE
EEQRTAPFYT PPAGPQVT
//
