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Database: UniProt
Entry: A0A075JRS7_9BACI
LinkDB: A0A075JRS7_9BACI
Original site: A0A075JRS7_9BACI 
ID   A0A075JRS7_9BACI        Unreviewed;       377 AA.
AC   A0A075JRS7;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   18-JUL-2018, entry version 19.
DE   RecName: Full=Alanine dehydrogenase {ECO:0000256|PIRNR:PIRNR000183};
DE            EC=1.4.1.1 {ECO:0000256|PIRNR:PIRNR000183};
GN   ORFNames=X953_14885 {ECO:0000313|EMBL:AIF44295.1};
OS   Virgibacillus sp. SK37.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Virgibacillus.
OX   NCBI_TaxID=403957 {ECO:0000313|EMBL:AIF44295.1, ECO:0000313|Proteomes:UP000027985};
RN   [1] {ECO:0000313|EMBL:AIF44295.1, ECO:0000313|Proteomes:UP000027985}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SK37 {ECO:0000313|EMBL:AIF44295.1,
RC   ECO:0000313|Proteomes:UP000027985};
RA   Phrommao E., Yongsawatdigul J., Rodtong S., Steele J.L.;
RT   "Complete genome sequence of Virgibacillus sp. SK37, a moderately
RT   halophilic bacterium isolated from Thai fish sauce fermentation.";
RL   Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: L-alanine + H(2)O + NAD(+) = pyruvate + NH(3)
CC       + NADH. {ECO:0000256|PIRNR:PIRNR000183}.
CC   -!- PATHWAY: Amino-acid degradation; L-alanine degradation via
CC       dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step
CC       1/1. {ECO:0000256|PIRNR:PIRNR000183}.
CC   -!- SIMILARITY: Belongs to the AlaDH/PNT family.
CC       {ECO:0000256|PIRNR:PIRNR000183}.
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DR   EMBL; CP007161; AIF44295.1; -; Genomic_DNA.
DR   RefSeq; WP_040956173.1; NZ_CP007161.1.
DR   EnsemblBacteria; AIF44295; AIF44295; X953_14885.
DR   KEGG; vir:X953_14885; -.
DR   KO; K00259; -.
DR   UniPathway; UPA00527; UER00585.
DR   Proteomes; UP000027985; Chromosome.
DR   GO; GO:0000286; F:alanine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0042853; P:L-alanine catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd05305; L-AlaDH; 1.
DR   InterPro; IPR008141; Ala_DH.
DR   InterPro; IPR007886; AlaDH/PNT_N.
DR   InterPro; IPR007698; AlaDH/PNT_NAD(H)-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR42795; PTHR42795; 1.
DR   Pfam; PF01262; AlaDh_PNT_C; 1.
DR   Pfam; PF05222; AlaDh_PNT_N; 1.
DR   PIRSF; PIRSF000183; Alanine_dh; 1.
DR   SMART; SM01002; AlaDh_PNT_C; 1.
DR   SMART; SM01003; AlaDh_PNT_N; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR00518; alaDH; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000027985};
KW   NAD {ECO:0000256|PIRNR:PIRNR000183, ECO:0000256|PIRSR:PIRSR000183-3};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000183-3};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000183};
KW   Reference proteome {ECO:0000313|Proteomes:UP000027985}.
FT   DOMAIN        4    136       AlaDh_PNT_N. {ECO:0000259|SMART:SM01003}.
FT   DOMAIN      148    297       AlaDh_PNT_C. {ECO:0000259|SMART:SM01002}.
FT   NP_BIND     238    239       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
FT   NP_BIND     266    269       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
FT   NP_BIND     298    301       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
FT   ACT_SITE     95     95       Proton donor/acceptor.
FT                                {ECO:0000256|PIRSR:PIRSR000183-1}.
FT   ACT_SITE    269    269       Proton donor/acceptor.
FT                                {ECO:0000256|PIRSR:PIRSR000183-1}.
FT   BINDING      15     15       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000183-2}.
FT   BINDING      74     74       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000183-2}.
FT   BINDING     133    133       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
FT   BINDING     197    197       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
FT   BINDING     202    202       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
FT   BINDING     219    219       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
FT   BINDING     279    279       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
SQ   SEQUENCE   377 AA;  39938 MW;  5DFDA57D5824B3D4 CRC64;
     MIVGVPREVK NNERRVALTP SGVTAFVNAG HTVLIESSAG NESGFLNEEY KAAGAIIVST
     AAEAWAAEMV MKVKEPQPQE FQYLREGLIL FTYLHLAAEP ELTEQLLKKK VTAIAYETIQ
     NSDRSLPLLA PMSEIAGRMA VQIGAQYLEN VKGGKGILLG GVPGVQPGNV VIIGGGAVGT
     NAAKMALGLR AKVTIIDINA NRLRELDDLF GGAVTTLMSN PLNIKNAVKE ADLLVGAVLI
     PGAKAPQLVS EEMVKEMMPG SVIIDVAVDQ GGSIETIDRV TTHDDPIYKK HGVLHYAVAN
     MPGAVARTAT LSLTNNTSQF GVFLANKGFK KAIEANPAFA KGVNTHAGMI THETIANAFT
     KEYTPLAEAL TKPVASY
//
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