ID A0A075LIZ1_9BACI Unreviewed; 258 AA.
AC A0A075LIZ1;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Global transcriptional regulator CodY {ECO:0000256|ARBA:ARBA00034538, ECO:0000256|HAMAP-Rule:MF_00621};
GN Name=codY {ECO:0000256|HAMAP-Rule:MF_00621};
GN ORFNames=GZ22_06825 {ECO:0000313|EMBL:AIF66369.1};
OS Terribacillus goriensis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Terribacillus.
OX NCBI_TaxID=386490 {ECO:0000313|EMBL:AIF66369.1, ECO:0000313|Proteomes:UP000027980};
RN [1] {ECO:0000313|EMBL:AIF66369.1, ECO:0000313|Proteomes:UP000027980}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MP602 {ECO:0000313|EMBL:AIF66369.1,
RC ECO:0000313|Proteomes:UP000027980};
RA Wang Y., Lu P., Zhang L.;
RT "Complete genome sequence of a moderately halophilic bacterium
RT Terribacillus aidingensis MP602, isolated from Cryptomeria fortunei in
RT Tianmu mountain in China.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-binding global transcriptional regulator which is
CC involved in the adaptive response to starvation and acts by directly or
CC indirectly controlling the expression of numerous genes in response to
CC nutrient availability. During rapid exponential growth, CodY is highly
CC active and represses genes whose products allow adaptation to nutrient
CC depletion. {ECO:0000256|HAMAP-Rule:MF_00621}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00621}.
CC -!- SIMILARITY: Belongs to the CodY family. {ECO:0000256|HAMAP-
CC Rule:MF_00621}.
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DR EMBL; CP008876; AIF66369.1; -; Genomic_DNA.
DR RefSeq; WP_038560167.1; NZ_KZ614143.1.
DR AlphaFoldDB; A0A075LIZ1; -.
DR KEGG; tap:GZ22_06825; -.
DR HOGENOM; CLU_089581_0_0_9; -.
DR OrthoDB; 2056at2; -.
DR Proteomes; UP000027980; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00621; HTH_type_CodY; 1.
DR InterPro; IPR014154; CodY.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR013198; GTP_trans_reg_CodY_C.
DR InterPro; IPR010312; Transc_reg_CodY_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR02787; codY_Gpos; 1.
DR PANTHER; PTHR40062:SF1; GLOBAL TRANSCRIPTIONAL REGULATOR CODY; 1.
DR PANTHER; PTHR40062; GTP-SENSING TRANSCRIPTIONAL PLEIOTROPIC REPRESSOR CODY; 1.
DR Pfam; PF06018; CodY; 1.
DR Pfam; PF08222; HTH_CodY; 1.
DR PIRSF; PIRSF011572; GTP_sensing_CodY; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00621};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00621}; Phosphoprotein {ECO:0000256|HAMAP-Rule:MF_00621};
KW Reference proteome {ECO:0000313|Proteomes:UP000027980};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00621};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00621};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00621}.
FT DOMAIN 2..178
FT /note="Global transcriptional regulator CodY N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06018"
FT DOMAIN 198..255
FT /note="Global transcriptional regulator CodY C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08222"
FT DNA_BIND 203..222
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00621"
FT REGION 1..155
FT /note="GAF domain"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00621"
FT MOD_RES 215
FT /note="Phosphoserine"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00621"
SQ SEQUENCE 258 AA; 28513 MW; 0170884040E05B5A CRC64;
MKLLDKARDI NFMLQKTAGK AVNFNNMSDT LQQVIESNIF IVSRRGKLLG VSINQAIEND
RMKQMLEEKQ FPKEYTEGLF QVQQTTANIG IDSPYTAFPV ENKDLFQGGL TTIVPIIGGG
ERLGTLILSR LAENFSDDDL LLAEYGATVV GMEILHQKTA EIETEARSKA VVQMAISSLS
YSELEAIEHI FEELDGSEGL LVASKVADRV GITRSVIVNA LRKLESAGVI ESRSLGMKGT
YIKVLNNKFL VELQKHTS
//
