ID A0A075LVF9_9EURY Unreviewed; 333 AA.
AC A0A075LVF9;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=2-hydroxyacid dehydrogenase {ECO:0000313|EMBL:AIF69997.1};
GN ORFNames=PAP_08045 {ECO:0000313|EMBL:AIF69997.1};
OS Palaeococcus pacificus DY20341.
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Palaeococcus.
OX NCBI_TaxID=1343739 {ECO:0000313|EMBL:AIF69997.1, ECO:0000313|Proteomes:UP000027981};
RN [1] {ECO:0000313|Proteomes:UP000027981}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DY20341 {ECO:0000313|Proteomes:UP000027981};
RA Zeng X., Shao Z.;
RT "Complete Genome Sequence of Hyperthermophilic Palaeococcus pacificus
RT DY20341T, Isolated from a Deep-Sea Hydrothermal Sediments.";
RL Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AIF69997.1, ECO:0000313|Proteomes:UP000027981}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DY20341 {ECO:0000313|EMBL:AIF69997.1,
RC ECO:0000313|Proteomes:UP000027981};
RX PubMed=26383653;
RA Zeng X., Jebbar M., Shao Z.;
RT "Complete Genome Sequence of Hyperthermophilic Piezophilic Archaeon
RT Palaeococcus pacificus DY20341T, Isolated from Deep-Sea Hydrothermal
RT Sediments.";
RL Genome Announc. 3:e01080-e01015(2015).
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR EMBL; CP006019; AIF69997.1; -; Genomic_DNA.
DR RefSeq; WP_048165494.1; NZ_CP006019.1.
DR AlphaFoldDB; A0A075LVF9; -.
DR STRING; 1343739.PAP_08045; -.
DR GeneID; 24842710; -.
DR KEGG; ppac:PAP_08045; -.
DR eggNOG; arCOG01755; Archaea.
DR HOGENOM; CLU_019796_1_3_2; -.
DR OrthoDB; 34275at2157; -.
DR Proteomes; UP000027981; Chromosome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd05301; GDH; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996:SF178; 2-HYDROXYACID DEHYDROGENASE YGL185C-RELATED; 1.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003719}.
FT DOMAIN 6..318
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 106..286
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 333 AA; 37675 MW; B25FFBCC71D99B45 CRC64;
MRPKVLVLFK MKSKPLEELK KYCDVDLLVY PSKEELLKVI AKYDALIVSP LNRIDGEVIE
KAERLKVIST HSAGYDHIDV EAATKKGIYV TKVSGVLSEA VAEFAIGLMI ALLRKIAYTD
KFIRLGKWES HRTVWSKFKD IETVYGKKVG ILGMGPIGKA IAKRAKALGT EIYYWSRHRK
EDIEEEVGAK YLPLEEVLTE SDIVVLALPA AKETYHIINE ERLKLLEGKY LINIGRGTLI
DEKALIKALK EGKLKGFATD VYEKEPLQES ELFEMGWETV LTPHHAGLSE EAMEDMGFQA
VKNLLAIFRG EIPKDLVNGE VFKIKRIDEV KML
//
