ID A0A075MJ90_9PROT Unreviewed; 476 AA.
AC A0A075MJ90;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Membrane fusion protein (MFP) family protein {ECO:0000256|RuleBase:RU365093};
GN ORFNames=I862_01670 {ECO:0000313|EMBL:AIF80897.1};
OS endosymbiont of Acanthamoeba sp. UWC8.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Holosporales; Holosporaceae.
OX NCBI_TaxID=86106 {ECO:0000313|EMBL:AIF80897.1, ECO:0000313|Proteomes:UP000028183};
RN [1] {ECO:0000313|EMBL:AIF80897.1, ECO:0000313|Proteomes:UP000028183}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UWC8 {ECO:0000313|EMBL:AIF80897.1};
RX PubMed=25103769;
RA Wang Z., Wu M.;
RT "Complete Genome Sequence of the Endosymbiont of Acanthamoeba Strain UWC8,
RT an Amoeba Endosymbiont Belonging to the 'Candidatus Midichloriaceae' Family
RT in Rickettsiales.";
RL Genome Announc. 2:e00791-e00714(2014).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|RuleBase:RU365093}; Single-pass membrane protein
CC {ECO:0000256|RuleBase:RU365093}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477, ECO:0000256|RuleBase:RU365093}.
CC -!- SIMILARITY: Belongs to the outer membrane factor (OMF) (TC 1.B.17)
CC family. {ECO:0000256|ARBA:ARBA00007613}.
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DR EMBL; CP004403; AIF80897.1; -; Genomic_DNA.
DR RefSeq; WP_052646306.1; NZ_CP004403.1.
DR AlphaFoldDB; A0A075MJ90; -.
DR STRING; 86106.I862_01670; -.
DR KEGG; eaa:I862_01670; -.
DR eggNOG; COG0845; Bacteria.
DR HOGENOM; CLU_023976_1_1_5; -.
DR OrthoDB; 9810980at2; -.
DR Proteomes; UP000028183; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR InterPro; IPR003423; OMP_efflux.
DR InterPro; IPR006144; Secretion_HlyD_CS.
DR InterPro; IPR010129; T1SS_HlyD.
DR NCBIfam; TIGR01843; type_I_hlyD; 1.
DR PANTHER; PTHR30386:SF17; ALKALINE PROTEASE SECRETION PROTEIN APRE; 1.
DR PANTHER; PTHR30386; MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP; 1.
DR Pfam; PF13437; HlyD_3; 1.
DR Pfam; PF02321; OEP; 1.
DR PRINTS; PR01490; RTXTOXIND.
DR PROSITE; PS00543; HLYD_FAMILY; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|RuleBase:RU365093};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU365093}; Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365093};
KW Reference proteome {ECO:0000313|Proteomes:UP000028183};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU365093};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU365093};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365093}.
FT TRANSMEM 58..76
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365093"
FT COILED 198..277
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 476 AA; 54484 MW; F699B0ECC142F201 CRC64;
MRKNIISKLI SFKGFVPAAK KLYEEINSFM KGANPEEAKY IMQHSLDLKK QIYKPIKFTF
MVIGVAFGFF IVWGSLAPLD SAVIAQGHIV LSGNRKTIQH KEGGIIQAIL VKDGEVVKEN
QPLVILNDTS DKARLQISLS RLRATKAIEQ RLLAEKFDEE QIDFSDPIFD REVPEVEKII
KNQQSLFESK RKAYHGKKDI YNQKIVEQRE QIKGLEAMLK SYESQFKILQ EQYRNLETLF
NKGYAKKTEL LEQRRRVQEL EGRVGQIKAD IANAHEAISE NQLHIISLEN ENQKEVDDEL
KETYSKILDL KEQYEADKDI LERTIIRAPN AGIVTGLKFH TVGGVVGQGA PILEIIPQDD
KLIVEAHVEP KDIESIREGL KAKVQLSAYK TRLVPRIDGE VIYVSADTIE DRSKQQPFYY
VAKIEIKPEA IESINYDIKL QPGMPAETFI IKGERTFLQY LLSPILDSFH KAFKEK
//
