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Database: UniProt
Entry: A0A075R0L2_BRELA
LinkDB: A0A075R0L2_BRELA
Original site: A0A075R0L2_BRELA 
ID   A0A075R0L2_BRELA        Unreviewed;       374 AA.
AC   A0A075R0L2;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   18-JUL-2018, entry version 21.
DE   RecName: Full=Alanine dehydrogenase {ECO:0000256|PIRNR:PIRNR000183};
DE            EC=1.4.1.1 {ECO:0000256|PIRNR:PIRNR000183};
GN   ORFNames=BRLA_c010590 {ECO:0000313|EMBL:AIG25399.1};
OS   Brevibacillus laterosporus LMG 15441.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Paenibacillaceae;
OC   Brevibacillus.
OX   NCBI_TaxID=1042163 {ECO:0000313|EMBL:AIG25399.1, ECO:0000313|Proteomes:UP000005850};
RN   [1] {ECO:0000313|EMBL:AIG25399.1, ECO:0000313|Proteomes:UP000005850}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 15441 {ECO:0000313|EMBL:AIG25399.1,
RC   ECO:0000313|Proteomes:UP000005850};
RX   PubMed=21914864; DOI=10.1128/JB.05696-11;
RA   Djukic M., Poehlein A., Thurmer A., Daniel R.;
RT   "Genome sequence of Brevibacillus laterosporus LMG 15441, a pathogen
RT   of invertebrates.";
RL   J. Bacteriol. 193:5535-5536(2011).
CC   -!- CATALYTIC ACTIVITY: L-alanine + H(2)O + NAD(+) = pyruvate + NH(3)
CC       + NADH. {ECO:0000256|PIRNR:PIRNR000183}.
CC   -!- PATHWAY: Amino-acid degradation; L-alanine degradation via
CC       dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step
CC       1/1. {ECO:0000256|PIRNR:PIRNR000183}.
CC   -!- SIMILARITY: Belongs to the AlaDH/PNT family.
CC       {ECO:0000256|PIRNR:PIRNR000183}.
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DR   EMBL; CP007806; AIG25399.1; -; Genomic_DNA.
DR   RefSeq; WP_003335070.1; NZ_CP007806.1.
DR   ProteinModelPortal; A0A075R0L2; -.
DR   STRING; 1042163.BRLA_c14700; -.
DR   EnsemblBacteria; AIG25399; AIG25399; BRLA_c010590.
DR   GeneID; 34878641; -.
DR   KEGG; blr:BRLA_c010590; -.
DR   eggNOG; ENOG4105DCF; Bacteria.
DR   eggNOG; COG0686; LUCA.
DR   KO; K00259; -.
DR   UniPathway; UPA00527; UER00585.
DR   Proteomes; UP000005850; Chromosome.
DR   GO; GO:0000286; F:alanine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0042853; P:L-alanine catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd05305; L-AlaDH; 1.
DR   InterPro; IPR008141; Ala_DH.
DR   InterPro; IPR008143; Ala_DH/PNT_CS2.
DR   InterPro; IPR008142; AlaDH/PNT_CS1.
DR   InterPro; IPR007886; AlaDH/PNT_N.
DR   InterPro; IPR007698; AlaDH/PNT_NAD(H)-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR42795; PTHR42795; 1.
DR   Pfam; PF01262; AlaDh_PNT_C; 1.
DR   Pfam; PF05222; AlaDh_PNT_N; 1.
DR   PIRSF; PIRSF000183; Alanine_dh; 1.
DR   SMART; SM01002; AlaDh_PNT_C; 1.
DR   SMART; SM01003; AlaDh_PNT_N; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR00518; alaDH; 1.
DR   PROSITE; PS00836; ALADH_PNT_1; 1.
DR   PROSITE; PS00837; ALADH_PNT_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005850};
KW   NAD {ECO:0000256|PIRNR:PIRNR000183, ECO:0000256|PIRSR:PIRSR000183-3};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000183-3};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000183,
KW   ECO:0000313|EMBL:AIG25399.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005850}.
FT   DOMAIN        4    136       AlaDh_PNT_N. {ECO:0000259|SMART:SM01003}.
FT   DOMAIN      148    297       AlaDh_PNT_C. {ECO:0000259|SMART:SM01002}.
FT   NP_BIND     238    239       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
FT   NP_BIND     266    269       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
FT   NP_BIND     298    301       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
FT   ACT_SITE     95     95       Proton donor/acceptor.
FT                                {ECO:0000256|PIRSR:PIRSR000183-1}.
FT   ACT_SITE    269    269       Proton donor/acceptor.
FT                                {ECO:0000256|PIRSR:PIRSR000183-1}.
FT   BINDING      15     15       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000183-2}.
FT   BINDING      74     74       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000183-2}.
FT   BINDING     133    133       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
FT   BINDING     197    197       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
FT   BINDING     202    202       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
FT   BINDING     219    219       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
FT   BINDING     279    279       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
SQ   SEQUENCE   374 AA;  39940 MW;  9EBACBED3E4CB17F CRC64;
     MRIGIPKEIK NNENRVAMTP AGAMNLVKNG HEIFIETSAG FGSGFTDEQF VAAGAKIVQT
     AQEAWGMDMV MKVKEPLPSE YQYFREGLIL FTYLHLAPEP ELTKALVDNK VIGIAYETVQ
     LSNGSLPLLT PMSEVAGRMS TQIGAQFLEK QEGGKGILLG GVPGVQRGKV TIVGGGVAGT
     NAAKMAVGLG ADVTIIDLNP DRLRQIEDIF GHSVKTLMSN PFNIAHAVQE SDLVIGAVLI
     PGAKAPKLVS EEMVKSMQPG SVLVDIAIDQ GGIFETTDRI TTHDNPTYEK HGVVHYAVAN
     MPGAVPRTST FALTNVTVPY AVQIANKGYQ KACLENPALL KGINTLNGHV TYQAVAQALG
     YESVDAKELL EQQS
//
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