ID A0A075R9I8_BRELA Unreviewed; 2544 AA.
AC A0A075R9I8;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=NRPS domain-containing protein {ECO:0000313|EMBL:AIG28061.1};
GN Name=tycC_8 {ECO:0000313|EMBL:AIG28061.1};
GN ORFNames=BRLA_c037610 {ECO:0000313|EMBL:AIG28061.1};
OS Brevibacillus laterosporus LMG 15441.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Brevibacillus.
OX NCBI_TaxID=1042163 {ECO:0000313|EMBL:AIG28061.1, ECO:0000313|Proteomes:UP000005850};
RN [1] {ECO:0000313|EMBL:AIG28061.1, ECO:0000313|Proteomes:UP000005850}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 15441 {ECO:0000313|EMBL:AIG28061.1,
RC ECO:0000313|Proteomes:UP000005850};
RX PubMed=21914864; DOI=10.1128/JB.05696-11;
RA Djukic M., Poehlein A., Thurmer A., Daniel R.;
RT "Genome sequence of Brevibacillus laterosporus LMG 15441, a pathogen of
RT invertebrates.";
RL J. Bacteriol. 193:5535-5536(2011).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; CP007806; AIG28061.1; -; Genomic_DNA.
DR RefSeq; WP_003338770.1; NZ_CP007806.1.
DR STRING; 1042163.BRLA_c037610; -.
DR KEGG; blr:BRLA_c037610; -.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_000022_44_1_9; -.
DR Proteomes; UP000005850; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 2.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR CDD; cd05235; SDR_e1; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR010080; Thioester_reductase-like_dom.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR NCBIfam; TIGR01746; Thioester-redct; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 3: Inferred from homology;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005850}.
FT DOMAIN 990..1067
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2058..2132
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2132..2154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2544 AA; 290945 MW; CC13B040D890C269 CRC64;
MFIKKNYVRG EREQHSPDQQ ALELTNAEKS LWIAHQMNPA SCNEPLGVKL KGEVSLILLQ
EALDRIVQRH PALRMIFICQ DGENPQKLIL PQVNVPITPH DFTAISPIEK ENMIQDTLEL
LRIEPFSLEE GPLLRPHLLK ISDEEYLFYV VFHHIIYDGW SSGIFLRELS AFYTALKKKE
QIAQAKQEDT GIAKLIQATE IGALAHHESD TYWANKMQGS IPYVGFSSDQ SPAKGLTYQG
DYISCIIDSA LMRKVEKFST DMQISVYRVM LTAYFILLHQ MTLEEDIVVG MPVNLRPRKG
FGEIFGYYIN TLPIRLSLAD VQGYNQLLKQ VDQHVREALQ HQHYRSESLI ENTDSTEKGD
RRIVSTVFNM VGLPTIEFEG LEAEVTYQFK RTTLFDIVWR VVKSEEKQYM IEIDFNTDLY
HSNTIENLLQ RYIHVLETLL QNPEASLHTL PFLIEEDYEI YKKINRNYLD FPTAKTLDQL
IDDQASQFPD RLAITMGEEA ITYKQLQDRT NQLAHYLLQH HLKKSERVAL LMDRHIDTII
AMIAILKAGG AYVPIDPDFP AERIQYMVAD SEATHLITRK KWAHKLPNDF GCCLLWEEIP
TDLPVDSVEA CHTPEDIAYM IYTSGSTGNP KGVLLSHIGV VNLIYSLKDK YKYTEKDVYL
QFASLIFDAS VWEIYSSLLC GGRLHLLSDL DRTSPENFVQ TVNSTKANYC VLPVIYFKQL
SQLPEETLEQ LHSLKAIFIG GETLSPEAVR MWQRKVGTRI LIANAYGPTE ATVCKTIYDI
TELLPEEQQS IPIGKPLANS EIFILNKHGM LCPLNVPGEI ILGGVGLAKG YLNQAEQTKT
AFVSLALPNQ PEKRFYRTGD IGRILPDGNL EFMGRIDHQV KIRGYRIELD EIETVLLQHP
KVKDSAIVVY KDDHDRSRLV AFYMTADSDG DVPVDELVTY LNQRLPVYMV PEHFYTLSSM
PLSPSGKVDR KSLAQQARSL MTTESRIYLS PNTPTEKAVV KIWAKVLQIE EARISINDDF
FALGGHSLIA IKVINQVQKQ LEAKIELKDL FQYRTVERLA VFIDEQATTN TAYQVSKDID
KLPHVIEQEH YTLSNAQKRL WFLEKWNNSV GVYHVPLQMK IKPGLDPDLF RQALEILINR
HEILRTTFVE FQGEPRQVIH NSFELALYHK DLSHLHEEQQ KALIEEEIRN DMKEPFDLSN
GPLFRISLYS LSDELSHLYL NFHHLITDEW SIQLLLQECM EVYQAQEQGK KPSLQPIERR
YIDYAEWQEQ KLREGYWKAE EAYWLEQLKG PLPVLELPLD FIRPKEQTFE GETVDFPLTK
KLTQQLKEVG KAESVTMNML LLSAYFKLLS HFSGQEDIIV GTPIAGRIHE AVEHIQGFFV
NTLAIRMNFQ GVDTLHQLIQ KVKETTLAAY HHQAYPFDSL IELINPDRME NQTPIFSTLF
TYENDLNLQQ SDYQLEVLPC DINTSKFDLS LAVYEKNQQL HLAFEYNKDL FTQDTISRFA
GSLEKILEAF INQRLSAPHL LDLLTDEEKQ LYQEVNGTKA AYPFEQTIQE RFYEQASKYP
SKIAISMGEQ SLTYEEVNHA SNQVAHYLRF TGMRPQEKVA ILLDRSIESI IAMLGILKAG
GAYVPIDTGY PKDRIEYILE DSQTSYMITR DAHMKGLSRY TGVIVRMEDV YELGQTNHVE
TLNTAEDIAY VIYTSGSTGK PKGTLLRHRG VLNLIQWRKD QFQVNCEDTF VQFASFSFDT
SVSEIFSALL HGARLHILSE DERYSVSAYA LAVQKVQATI TDVPIVFFHN VIASLSNTEA
EMVKTLRMMM VGGEALPAES VRAWHNRFGQ QTLIINEYGP TEATVSATFY PIHRIEPEQK
NVPIGKPLAN TKIHILHSQK TPCPIGAIGE IYIESVGLSP GYWNQEKKNE EVFISNPFTH
QFADRLYRTG DLARWLPDGN IEFVGRRDDQ IKIRGYRVEL GEIEETLLQH PLIHQSVVLA
VDSGAEKVLV SYYTTNSQQE IQASELNSYL SGTLPEYMLP RHYIYLEELP LTPNGKVDRK
SLMQNSPHFV KKERSFTKPE TELQIEIAQI WEQVLDVKPV GLEDDFFELG GHSLKIMPVL
VQLKPKYPMI RIQDFFKFRT VAKLAQYLEE KQEQSTKSTQ STEQSPIATK PVTNQIQKKR
EKVSNITVNV PKGVFLTGAT GFLGAYILKE LLEIPSIPIH CLVRKTGDAS IDRKLEDKMV
FYFGQDVLSQ MKGRVFTVEG DLSSKGLGMD SLVWDHIAGK IDSVIHCGGE VRHYGDREHF
HKVNLESTNE LIQLSKKLKA RFHYISTLSV VGHSIHDPAE FMFYETDFDR GQEIENVYVE
SKFLSEKSVR QAMEEGLDAT IYRVGNLVGH SVTGKFQYNI HENAFYRLLK AIFLLRVAPS
ISGYMDLTPI DYGSKAIVQL SCQLETIGET LHICNPAQIT WEDFIRNIQQ AGYPVSLIQA
EEYIQTLYQG DLSDEQQQAL ELILPSLEAS EGMSISIPDC ALVQEFLQNT AVVCPKPTEQ
LIRSMIEYAV EVDFFPAIQE TILK
//
