ID A0A075RD59_BRELA Unreviewed; 2337 AA.
AC A0A075RD59;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE SubName: Full=NRPS domain-containing protein {ECO:0000313|EMBL:AIG27345.1};
GN Name=tycC_6 {ECO:0000313|EMBL:AIG27345.1};
GN ORFNames=BRLA_c030330 {ECO:0000313|EMBL:AIG27345.1};
OS Brevibacillus laterosporus LMG 15441.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Brevibacillus.
OX NCBI_TaxID=1042163 {ECO:0000313|EMBL:AIG27345.1, ECO:0000313|Proteomes:UP000005850};
RN [1] {ECO:0000313|EMBL:AIG27345.1, ECO:0000313|Proteomes:UP000005850}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 15441 {ECO:0000313|EMBL:AIG27345.1,
RC ECO:0000313|Proteomes:UP000005850};
RX PubMed=21914864; DOI=10.1128/JB.05696-11;
RA Djukic M., Poehlein A., Thurmer A., Daniel R.;
RT "Genome sequence of Brevibacillus laterosporus LMG 15441, a pathogen of
RT invertebrates.";
RL J. Bacteriol. 193:5535-5536(2011).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP007806; AIG27345.1; -; Genomic_DNA.
DR RefSeq; WP_003335759.1; NZ_CP007806.1.
DR STRING; 1042163.BRLA_c030330; -.
DR KEGG; blr:BRLA_c030330; -.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_000022_0_13_9; -.
DR Proteomes; UP000005850; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 2.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 1.10.287.490; Helix hairpin bin; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020459; AMP-binding.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF00975; Thioesterase; 1.
DR PRINTS; PR00154; AMPBINDING.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 3: Inferred from homology;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005850}.
FT DOMAIN 974..1049
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2012..2087
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2337 AA; 268197 MW; 547BE738CFAD9C80 CRC64;
MNKDLLQLFS LTHPQQRIWY SELLYPNTGV SSISLTVKMK GNISLGALQQ ALNMIIFRHD
AFRIKLTAQN GYPQQYVEEY SEKSFECFNF SGVDGEAQAL KWLDQHNRTP FELLHSELYQ
FIICKISDQE YWYNVKIHHI VCDGISARMF INQVNEYYSQ IANDELPEIT KNHTYFDFIQ
TEQDYEKSDR YQKDKSYWVD KFSTLPEVIG FKSYNPLTLS TAGKRKNIIL EERLYYNLYE
FCKQTNSSML TVFMTALYIY LHKKTTQNDV SIGTFYANRI TKKEKEMLGM FVSTVPTRVF
VDPEMDLLSL LKVVSKEQVS ILRHQRFPYN QMMEDLREAH QHKDLQRLFG VSVQYRAMNY
SQYENVEIEV DENFCGDVIN DFEMNVIELD NQKILFQLNY RAQLFTEMEM EQLIQQFFTI
IETIIHHPTS KIADISLLRE EEKNMIISEF NNTVMEYPRE KLIHQLFEEQ VARIPDQIAV
ICEGEQLSYR ELNERANQLA RKLRAEGVVA DQLVGIMAER SLEMMIGIFG ILKAGGAYMP
IDPEFPEERI RYMLEDSKAK LLLGQNHLLE RVTFAGKIVD INDAQSYHQD GSNLEAINGP
NHLAYVIYTS GSTGKPKGVM IEHHSVINRL MWMHAKYPIS SADTIMQKTA ITFDVSVWEL
FWWSMVGSKM CLLPVGGEKN PEQILETIAE HRITTMHFVP AMLHAFLDYV EQQPSKLVEE
KLQSLRQVFA SGEALPPQHV DRFRQAVSSV CEARLINLYG PTEATVDVTY FDCDTDEELA
AIPIGKPIYN TQLYIVQANS ENLQPIGIAG ELCIAGVGLA RGYLNRPELT EEKFVKNPFV
AGERMYRTGD LARWLPDGNI EYLGRIDDQV KIRGVRIELG EIESQMRKLD GLREVVVVAK
QDQAKEKFLC AYMVTDREVS TAEIRAHLTT QLPIAMIPST FISLEAMPLT ANGKIDKRSL
PDPDNSLLNT EYVAPRTQLE VQLATVWQQV LGIDRVGCKD DFFALGGHSL RAMMVISQMH
KEYQMDIPLR VLFEKPTIEE IAQYLESERM KQIISIRPAT KQDYYPVSAA QRRMFILNQF
DGIDISYNMP SIMLLEGKLD LVKLETAFKG LINRHESLRT SFELVNGSPV QKIHSVVDFE
VDYQVTVEEE LEEIIDEFIK PFQLNMAPLL RVKLVQTRLD RYLLLVDTHH IISDGVSSGI
IISELVELYQ GNTLPELTIQ YKDFSEWQHE QSQTDLYKKQ EEHWVQTFAD EIPVLNLPTD
FPRPNTQSFD GDVITRGTGK ELMEGLYKIA ADTGTTLYMV LLAAYNVLLS KYSGQEDLIV
GTPVTGRSHV DLQSTVGMFV NTLAMRNKPA RSKSFREFLI EVKRNALQAY ENQDYPFEEL
VEKLELQSDV SRNPMFDTMF TLQNRGEDSI ELDELRFIAY ERENKWKHSK FDITFIATEE
RDQIMIGVEY CTKLYRQETI ERLTTNFLQI IKAIVDNPEV KLATIEILTN AEKNQLLQEF
NNTERNYQQD TTIHQLFEEQ VRKTPDQVAL IWNKKELTYQ ELNERANQLA RTLRNKGIVP
NQLVAIMVDR SVEMIVGIMG ILKAGAAYVP IDPAYPTERI EYVLEDSGAV LLLTQSHLFN
GLAVNMVRLD LDEEQNYVVD GTNLTVVNQP TDLAYVIYTS GTTGKPKGVM IEHHSIVNCL
QWRRDEYAFN PKDKALQIFS FAFDGFVASL FAPMLGGATS ILPREEEAKD PFALRKLIAS
ESITHYYGVP SLFNAIVDSA TAEDLHQLRC VTLGGEKLSP QIVQKIKQKN PAIEINNEYG
PTENSVVTTI QRAIEVDQAI TIGRPLANVT VYIVNNEHHL QPIGVVGELC IAGRGLGRGY
LNRPELTEEK FVANPFVPGE RMYKTGDLAK WRPDGTIEYV GRVDEQVKVR GFRIEIGEIE
STILQYHGVG EVVVTAQEDQ HAQQYLCAYF VAEKEVVLAD LRKFVSKELP AYMVPTYFVQ
LLELPTTANG KVDKRALPKP ENVGVAAKEY IAPRNMVEEQ LAAIWQEVLE VEKISITDHF
FEIGGHSLKA MLLISKVYEY MQEELPLHFV FQHPTIEKMA EFILHKQYEQ NAGHPILLNK
ETNRPVFSFT PIAAHSTFYQ KLAEEVHDIS LYSFDFIEED NRIEQYVNAI TQIDSEGPYT
LMGYSSGGNL AFEVAKVLEN QGRQVSSIIL FDSYWKDKTI EQTATEARKE IGAYFKKIAE
NNELFNMTKE DLEQFITNDF IKQSFFQNMF SYLMFHNQLV NRGNIKAAIH LIQAECEQGN
VTAYEAEKWN EEVWARASER FINYRGYGDH PRMLSGEQVT KNGSILKEIL EASFALK
//