ID A0A075WZ36_9BACT Unreviewed; 501 AA.
AC A0A075WZ36;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 08-NOV-2023, entry version 44.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN ORFNames=HL41_03640 {ECO:0000313|EMBL:AIH03942.1};
OS Thermodesulfobacterium commune DSM 2178.
OC Bacteria; Thermodesulfobacteriota; Thermodesulfobacteria;
OC Thermodesulfobacteriales; Thermodesulfobacteriaceae;
OC Thermodesulfobacterium.
OX NCBI_TaxID=289377 {ECO:0000313|EMBL:AIH03942.1, ECO:0000313|Proteomes:UP000028481};
RN [1] {ECO:0000313|EMBL:AIH03942.1, ECO:0000313|Proteomes:UP000028481}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 2178 {ECO:0000313|EMBL:AIH03942.1,
RC ECO:0000313|Proteomes:UP000028481};
RX PubMed=25635017;
RA Bhatnagar S., Badger J.H., Madupu R., Khouri H.M., O'Connor E.M.,
RA Robb F.T., Ward N.L., Eisen J.A.;
RT "Genome Sequence of a Sulfate-Reducing Thermophilic Bacterium,
RT Thermodesulfobacterium commune DSM 2178T (Phylum Thermodesulfobacteria).";
RL Genome Announc. 3:0-0(2015).
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|RuleBase:RU003960}.
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DR EMBL; CP008796; AIH03942.1; -; Genomic_DNA.
DR RefSeq; WP_038060367.1; NZ_JQLF01000005.1.
DR AlphaFoldDB; A0A075WZ36; -.
DR STRING; 289377.HL41_03640; -.
DR PaxDb; 289377-HL41_03640; -.
DR KEGG; tcm:HL41_03640; -.
DR eggNOG; COG0007; Bacteria.
DR eggNOG; COG1587; Bacteria.
DR HOGENOM; CLU_011276_6_0_0; -.
DR OrthoDB; 9815856at2; -.
DR Proteomes; UP000028481; Chromosome.
DR GO; GO:0004851; F:uroporphyrin-III C-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0019354; P:siroheme biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR CDD; cd11642; SUMT; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR006366; CobA/CysG_C.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR NCBIfam; TIGR01469; cobA_cysG_Cterm; 1.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00839; SUMT_1; 1.
DR PROSITE; PS00840; SUMT_2; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|RuleBase:RU003960};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW Reference proteome {ECO:0000313|Proteomes:UP000028481};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003960}.
FT DOMAIN 5..215
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 267..493
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 501 AA; 55420 MW; 56355ACB841D2323 CRC64;
MAQGKVYLVG AGPGDPQLLT LKGKRILEQA EVVIYDYLAN PKLLSFCKEG AEKIYVGKKG
GEHTLPQEEI NKLLVKKAKE GKKVVRLKGG DPFLFGRGGE ELEELVKEGI PFEVVPGVTS
AIAVPAYAGI PVTHRDYTST LAIITGHEAE GKPESKIDFK ALAKLGTLVF LMGVKNLKYI
VENLIKEGKD PKTPVALIQW GTLPKQKVVT GCLENIVAEV EKAGIKPPAI IVVGEVVKLR
PDFNWFERKP LFGKRIAITR TREQASRLSF LLEELGADVV ELPLIKVVPI CNTAFLERLN
LYDWLVFTSE NGVRFFIKTL LETERDLRVL KDLKIAVIGK ATAEALEGWG IKADLIPEKN
FTQEGLLEAF SKIPIEGKKV LIARAKEARD VLPRGLEELG AIVEVVPIYQ TVLPEETKIA
FKEELKQGID IITFTSSSTV KNFFRLLSEL EEEVELKNTL FASIGPITSQ ELIKHGVTPQ
IEAKEYTIPG LVEAILTYFS D
//
