ID A0A076FCW3_9VIRU Unreviewed; 1091 AA.
AC A0A076FCW3;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=PmNV_005 {ECO:0000313|EMBL:AII15793.1};
OS Penaeus monodon nudivirus.
OC Viruses; Naldaviricetes; Lefavirales; Nudiviridae; Gammanudivirus;
OC Gammanudivirus pemonodonis.
OX NCBI_TaxID=1529056 {ECO:0000313|EMBL:AII15793.1, ECO:0000313|Proteomes:UP000203413};
RN [1] {ECO:0000313|EMBL:AII15793.1, ECO:0000313|Proteomes:UP000203413}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Indonesia {ECO:0000313|EMBL:AII15793.1};
RX PubMed=25063321; DOI=10.1186/1471-2164-15-628;
RA Yang Y.T., Lee D.Y., Wang Y., Hu J.M., Li W.H., Leu J.H., Chang G.D.,
RA Ke H.M., Kang S.T., Lin S.S., Kou G.H., Lo C.F.;
RT "The genome and occlusion bodies of marine Penaeus monodon nudivirus (PmNV,
RT also known as MBV and PemoNPV) suggest that it should be assigned to a new
RT nudivirus genus that is distinct from the terrestrial nudiviruses.";
RL BMC Genomics 15:628-628(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755}.
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DR EMBL; KJ184318; AII15793.1; -; Genomic_DNA.
DR RefSeq; YP_009051843.1; NC_024692.1.
DR GeneID; 20098311; -.
DR KEGG; vg:20098311; -.
DR OrthoDB; 9861at10239; -.
DR Proteomes; UP000203413; Genome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00023109};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000203413};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral DNA replication {ECO:0000256|ARBA:ARBA00023109}.
FT DOMAIN 780..896
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
FT REGION 678..715
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..715
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1091 AA; 127272 MW; E945664B2EA5C39F CRC64;
MSVRYVNSNW KEWLSQVPDT PKSNYLYITD WQVDGDDYFG VGINKMTRKL EKFKVANLSS
GLYVWALNQQ TLKELLVNFT ISDITYVKQN TEYMNNHVTV LDDIMKSGRY QPKWKLFKLH
TTSFNESKSL HYSISNSTGF LQHIAVLGQW NLSTFMMMEF HVKGMDYIYG KYINERLQYL
ENIESNFNLF TTVYDIETVS NYDHRIPTGN FFADHIMSVT FIKGTEIITL FNIPLTFDHQ
LDAAKSIIDK ISAKDYYKME TRTTLVYNTE WDLLAKLFEL FESIDEAYIC LGYNSRNYDM
PFLLTRAIYL GMPQVSKFYY VNGILSYGMN MIHVDLNQVL VKYFAQELSS FSLKNVAKAL
LEDDDTQKVD FNARNLRYIY QFMIESGHLN NGKYDNVLCR QPNPWSISLD IMAKYNEMDC
LVVLALWDKL QYEHFITYAS RVFFLPLVRL GLSKLNEYLS TNMIYEGLQQ NTIFAHHTNS
SLTMNSQMMY TLNIENISSD ANKAFHGGFN ERKNRGCYHE VHAMDARAYY PELISGMNLS
HETASLLRIK DLKLIARGCT NFDESFKIMK FCTHKAINQN IKPPSTTCEN IINAIASAAY
VHCMVDNCPT IKFEDLDKYN DMDKVVVLHK THRGILSKII EQRNTLRNIA KSSKKEISSH
IDACQTLLSE YKLKNRMGSN KYNDDEEEEI SYSDDDDNND DNEEEISYDD YDDDDEDDMI
INKVYSIEDF KIPKDKHTEE AVYMVTKHIR LLEKKDFNKF EDAIKSLELY IEDLKLEFTR
LNSHYRNMKL LNNSIYGLLG ASYGTIKAKN LAAIVTMLGR HFIVEASRIG NMINANMIYS
DTDSVFFSIS NAIVKNSANR IISGVNRLNA NVVLNDKVYK DMFVLGKKTY IATCNDMIFS
RGINKNGPNL WKTMMDRFYV QFIKNRESLN FSGVYDILFD MYMDTYKLLY DNRNAILRLV
SIRTRESYKM NTVVTKLIDR ISLEKPDYKF DSKVYCFYRI FGDISNTHLA LDIEMDDTPI
EEINLYKFYS NIVSTYYLIF AYAIEQTNQE KLGYVIKYPM QEFNKANKYS FIKALAAIKE
MPTRDNDKQP T
//
