ID A0A076H7Y2_9SYNE Unreviewed; 391 AA.
AC A0A076H7Y2;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=RND efflux pump membrane fusion protein barrel-sandwich domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=KR49_05035 {ECO:0000313|EMBL:AII45820.1};
OS Synechococcus sp. KORDI-49.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales; Synechococcaceae;
OC Synechococcus.
OX NCBI_TaxID=585423 {ECO:0000313|EMBL:AII45820.1, ECO:0000313|Proteomes:UP000028589};
RN [1] {ECO:0000313|EMBL:AII45820.1, ECO:0000313|Proteomes:UP000028589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KORDI-49 {ECO:0000313|EMBL:AII45820.1,
RC ECO:0000313|Proteomes:UP000028589};
RA Choi D.H., Kwon K.-K., Lee J.-H., Noh J.H.;
RT "Genome sequences of Synechococcus sp. KORDI-49.";
RL Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; CP006270; AII45820.1; -; Genomic_DNA.
DR RefSeq; WP_043692135.1; NZ_CP006270.1.
DR AlphaFoldDB; A0A076H7Y2; -.
DR STRING; 585423.KR49_05035; -.
DR KEGG; synr:KR49_05035; -.
DR PATRIC; fig|585423.3.peg.965; -.
DR eggNOG; COG0845; Bacteria.
DR HOGENOM; CLU_018816_14_2_3; -.
DR OrthoDB; 505602at2; -.
DR Proteomes; UP000028589; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30469:SF15; HLYD FAMILY OF SECRETION PROTEINS; 1.
DR PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 74..313
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT DOMAIN 201..313
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 173..200
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 391 AA; 42744 MW; 2565BEBF0575A565 CRC64;
MLKTEQRPAL QPTPTVPDSP PPQRSFLQRN RLLGLGLLLA LLASGTALLR FAPWSARERD
LTPYTVLAET GSLSGVITAS GELQADRRVN ISPRKQGLLK ELMVDEGDVV EAGQVVALMD
PGDYGDRLDE RRALLRQAEA NFLGKRDEFE RRRQLHEQEV VSADDFSRVR NQMLASQAAV
IAARERIQQL EEEGRELRIR APFSGTITAR FAEPGAFVTP TTTASANAGA TSSSIVELSQ
GREVAAKVPE SDIGRIALGQ QAEIRVDAFP DERFQATVNE IAPRAEKRDN VTSFTVKLQL
KDPPERLRIG MTADINFQTG RSAPKTLVPT VAIVTENGKP GVLLVGEQQQ PSFQAVELGS
SSGDRTAILN GLPSGTRVFI DLPPWAKRER N
//
