ID A0A076MS17_AMYME Unreviewed; 391 AA.
AC A0A076MS17;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=8-amino-7-oxononanoate synthase {ECO:0000256|ARBA:ARBA00013187};
DE EC=2.3.1.47 {ECO:0000256|ARBA:ARBA00013187};
GN Name=bioF {ECO:0000313|EMBL:AIJ21756.1};
GN ORFNames=AMETH_1664 {ECO:0000313|EMBL:AIJ21756.1};
OS Amycolatopsis methanolica 239.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis; Amycolatopsis methanolica group.
OX NCBI_TaxID=1068978 {ECO:0000313|EMBL:AIJ21756.1, ECO:0000313|Proteomes:UP000062973};
RN [1] {ECO:0000313|EMBL:AIJ21756.1, ECO:0000313|Proteomes:UP000062973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=239 {ECO:0000313|EMBL:AIJ21756.1,
RC ECO:0000313|Proteomes:UP000062973};
RA Tang B.;
RT "Whole Genome Sequence of the Amycolatopsis methanolica 239.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-
CC oxononanoate + CO2 + holo-[ACP]; Xref=Rhea:RHEA:42288, Rhea:RHEA-
CC COMP:9685, Rhea:RHEA-COMP:9955, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:57972, ChEBI:CHEBI:64479, ChEBI:CHEBI:78846,
CC ChEBI:CHEBI:149468; EC=2.3.1.47;
CC Evidence={ECO:0000256|ARBA:ARBA00034067};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
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DR EMBL; CP009110; AIJ21756.1; -; Genomic_DNA.
DR RefSeq; WP_017987616.1; NZ_CP009110.1.
DR AlphaFoldDB; A0A076MS17; -.
DR STRING; 1068978.AMETH_1664; -.
DR KEGG; amq:AMETH_1664; -.
DR PATRIC; fig|1068978.7.peg.1752; -.
DR eggNOG; COG0156; Bacteria.
DR HOGENOM; CLU_015846_11_2_11; -.
DR OrthoDB; 9807157at2; -.
DR Proteomes; UP000062973; Chromosome.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR13693:SF100; 8-AMINO-7-OXONONANOATE SYNTHASE; 1.
DR PANTHER; PTHR13693; CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000062973}.
FT DOMAIN 42..381
FT /note="Aminotransferase class I/classII"
FT /evidence="ECO:0000259|Pfam:PF00155"
SQ SEQUENCE 391 AA; 40025 MW; A17C0880B567EA55 CRC64;
MNLPASSSPE QVFDWLDAAA EKRAAAGLTR RLRPRGASST ELDLAGNDYL GLARDKRVAG
AAAAAALRWG AGATGSRLDT GSTEVHTELE YELARFCGAQ AALVFSSGFT ANLGAVTALS
GAESAIVSDK HIHTSLIEGC RLSRTDVAAI SHCDPAAIKH ALATRRKPRA LVVTDSVFSV
EGDLAPLPEL SQVCREHGAA LLVDDAHGFG VLGDGGRGAV HAAGLAGEPD VVTTISLSKA
LGAQGGAVLG PRRVIRHLVD TARSFVFDTG LAPASAAAAL AALGVLKSEP DLPEKVLTNA
VALSAQLRAA GFRVSNPEAA VISVQAPSAE SAVEWADRCA EQGVRVGCFR PPSVPDGISR
LRLTVRADLT ESDVDTAVKV ISESAPAGAA S
//
