ID A0A076MWY9_AMYME Unreviewed; 307 AA.
AC A0A076MWY9;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Dihydrodipicolinate synthase {ECO:0000313|EMBL:AIJ25414.1};
GN Name=dapAch1 {ECO:0000313|EMBL:AIJ25414.1};
GN ORFNames=AMETH_5322 {ECO:0000313|EMBL:AIJ25414.1};
OS Amycolatopsis methanolica 239.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis; Amycolatopsis methanolica group.
OX NCBI_TaxID=1068978 {ECO:0000313|EMBL:AIJ25414.1, ECO:0000313|Proteomes:UP000062973};
RN [1] {ECO:0000313|EMBL:AIJ25414.1, ECO:0000313|Proteomes:UP000062973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=239 {ECO:0000313|EMBL:AIJ25414.1,
RC ECO:0000313|Proteomes:UP000062973};
RA Tang B.;
RT "Whole Genome Sequence of the Amycolatopsis methanolica 239.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DapA family.
CC {ECO:0000256|PIRNR:PIRNR001365}.
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DR EMBL; CP009110; AIJ25414.1; -; Genomic_DNA.
DR RefSeq; WP_017984259.1; NZ_CP009110.1.
DR AlphaFoldDB; A0A076MWY9; -.
DR STRING; 1068978.AMETH_5322; -.
DR KEGG; amq:AMETH_5322; -.
DR PATRIC; fig|1068978.7.peg.5713; -.
DR eggNOG; COG0329; Bacteria.
DR HOGENOM; CLU_049343_5_1_11; -.
DR OrthoDB; 3175637at2; -.
DR Proteomes; UP000062973; Chromosome.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR CDD; cd00408; DHDPS-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR InterPro; IPR020625; Schiff_base-form_aldolases_AS.
DR PANTHER; PTHR12128:SF72; 4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR PRINTS; PR00146; DHPICSNTHASE.
DR SMART; SM01130; DHDPS; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR PROSITE; PS00666; DHDPS_2; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365};
KW Reference proteome {ECO:0000313|Proteomes:UP000062973};
KW Schiff base {ECO:0000256|ARBA:ARBA00023270}.
FT ACT_SITE 135
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT ACT_SITE 163
FT /note="Schiff-base intermediate with substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT BINDING 209
FT /ligand="pyruvate"
FT /ligand_id="ChEBI:CHEBI:15361"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ SEQUENCE 307 AA; 33228 MW; CB310BE91A7C6A66 CRC64;
MTRFTGIIPP LCTPFRDDFT IDVDSLRRHL DVQLDAGVHG VFVLGSSSEV AFLPDRQRRV
VIETAVAHVG GRIPVLAGCI DMTTLRVAEH IRVAEEAGAD ALVITAPYYT RTHSAEIEQH
FRLLHAQASL PIFAYDIPVA VHSKLDREMV LRLAEDGVLA GLKDSSGDEA GFGALLLGRR
ERGLSEFAVF TGSELVVDLA LQMGADGAVP GLANVDPAGY VTIWDRVRAG DLATARREQD
RLMRLYDITH AAPPERMGRG SAGLGAFKAA MKMRGFIDNS VMAPPQLPLN DEELLRIKGA
LTEAGLL
//
