ID A0A076N5Q2_AMYME Unreviewed; 300 AA.
AC A0A076N5Q2;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=UTP--glucose-1-phosphate uridylyltransferase {ECO:0000256|ARBA:ARBA00012415};
DE EC=2.7.7.9 {ECO:0000256|ARBA:ARBA00012415};
GN Name=galU {ECO:0000313|EMBL:AIJ26145.1};
GN ORFNames=AMETH_6053 {ECO:0000313|EMBL:AIJ26145.1};
OS Amycolatopsis methanolica 239.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis; Amycolatopsis methanolica group.
OX NCBI_TaxID=1068978 {ECO:0000313|EMBL:AIJ26145.1, ECO:0000313|Proteomes:UP000062973};
RN [1] {ECO:0000313|EMBL:AIJ26145.1, ECO:0000313|Proteomes:UP000062973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=239 {ECO:0000313|EMBL:AIJ26145.1,
RC ECO:0000313|Proteomes:UP000062973};
RA Tang B.;
RT "Whole Genome Sequence of the Amycolatopsis methanolica 239.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-
CC alpha-D-glucose; Xref=Rhea:RHEA:19889, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:58601,
CC ChEBI:CHEBI:58885; EC=2.7.7.9;
CC Evidence={ECO:0000256|ARBA:ARBA00000872};
CC -!- SIMILARITY: Belongs to the UDPGP type 2 family.
CC {ECO:0000256|ARBA:ARBA00006890}.
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DR EMBL; CP009110; AIJ26145.1; -; Genomic_DNA.
DR RefSeq; WP_017984983.1; NZ_CP009110.1.
DR AlphaFoldDB; A0A076N5Q2; -.
DR STRING; 1068978.AMETH_6053; -.
DR KEGG; amq:AMETH_6053; -.
DR PATRIC; fig|1068978.7.peg.6505; -.
DR eggNOG; COG1210; Bacteria.
DR HOGENOM; CLU_029499_1_0_11; -.
DR OrthoDB; 9803306at2; -.
DR Proteomes; UP000062973; Chromosome.
DR GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR CDD; cd02541; UGPase_prokaryotic; 1.
DR InterPro; IPR005771; GalU_uridylyltTrfase_bac/arc.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR43197; UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR PANTHER; PTHR43197:SF1; UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000062973}.
FT DOMAIN 13..276
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
SQ SEQUENCE 300 AA; 31923 MW; 26B8827F4CA1E61B CRC64;
MTGAFDNHSF RTAIVPAAGL GTRFLPTTKA VPKELLPVVD TPGIEIVASE AAQAGAKRLV
IVTSPGKESV VNYFRPSPEL EANLERKGKS ALLEKVRRGA ELIDVEVAIQ EEALGLGHAV
AQAEPNLTDE DAAVAVLLPD DLVLPAGVLS KMAEVRAKHG GSVLCAFDIP KEQISPYGVF
DVTDTGDADV KQVHGMVEKP SPEEAPSTYA AAGRYLLDRA IFDALRRIEP GAGGELQLTD
AVALLIEEGH PVHIVVHRGG RHDLGNPGGF LKAAVDFALD DPDYGPELRN WLTERLGTDR
//
