ID A0A076YK32_9CAUD Unreviewed; 610 AA.
AC A0A076YK32;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=DNA polymerase I {ECO:0000313|EMBL:AIK69081.1};
GN ORFNames=PBI_TRIKE_42 {ECO:0000313|EMBL:AIK69081.1};
OS Mycobacterium phage Trike.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Fromanvirus.
OX NCBI_TaxID=1527536 {ECO:0000313|EMBL:AIK69081.1, ECO:0000313|Proteomes:UP000203024};
RN [1] {ECO:0000313|EMBL:AIK69081.1, ECO:0000313|Proteomes:UP000203024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Rizzo E., Jackson S., Arceneaux J., Baudin R., Beutner R., Borque M.,
RA Crawford L., Fontenot A., Gillikin B., Hayes M., Johnston R., Kurz M.,
RA Mouawad M., Reed A., Schilling C., Streeter Z., Vu J., Wilson T.,
RA Jernigan G., Dammann K., Harmson J., Bhuiyan S., Scott A., Miller B.,
RA Jones J.D., Gissendanner C.R., Wiedemeier A.M.D., Findley A.M.,
RA Anders K.R., Braun M.A., Delesalle V.A., Hughes L.E., Ware V.C.,
RA Bradley K.W., Barker L.P., Asai D.J., Bowman C.A., Russell D.A., Pope W.H.,
RA Jacobs-Sera D., Hendrix R.W., Hatfull G.F.;
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
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DR EMBL; KM101120; AIK69081.1; -; Genomic_DNA.
DR RefSeq; YP_009124961.1; NC_026591.1.
DR GeneID; 23679733; -.
DR KEGG; vg:23679733; -.
DR OrthoDB; 14842at10239; -.
DR Proteomes; UP000203024; Genome.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00447; DNA_POLYMERASE_A; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00023109};
KW Viral DNA replication {ECO:0000256|ARBA:ARBA00023109}.
FT DOMAIN 15..192
FT /note="3'-5' exonuclease"
FT /evidence="ECO:0000259|SMART:SM00474"
FT DOMAIN 373..570
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
SQ SEQUENCE 610 AA; 68091 MW; 1FBECF242301F2EF CRC64;
MIEHRHEVAG DEVVIRVVEN EDDLEGFRDF IRAHLGFLGL DSETTGLDIY NDGFRCRLVQ
FGTPDEAWVV PVELGPRYEH EVREALRNVK GFVLHNASFD LQVFDKTLGV PMEELWPKVT
DTRILAHLVD PRGKDEGGVG HSLEEMTRAH IDAEVADNVK TLMADLAKAN GTTKANVWKK
VPLQDPHYQL YSGMDPILAA RLLRKLVRLV DAKDELIRNE HKIAEICAYM ERTGFLLDVE
YTEKLSDTLK FDESRWSEVA LNYGCENVNS TEQVADTLQA LGVKITGRTP SGKRQVNDDL
LSGLIKSEHA AAEFAQSVIE AKKAGKWRKT WVDTFLKTRD GQNRCHASIN PLRARTARMS
ITGIPAQTLP SGDYTIRRCF VADEGHRIAS VDYQAQELRV LAALSKDETM IQAFLDDADL
HLMTARAAWP DREITKDSPE RKYAKVVNFG RVYGGGAKTV SEQTGLDLAQ AKVVVDGFDK
AYPGVQKLSL KLQREASRNG YIRTPFIDGL GGRKLPVDPT RAYSALNYLI QSSSRDVTAR
ALIRLHENGF TPYLRLPIHD EILASVPAEH AEWGAKRIGE LMAEQMGPVL IGTDPEVGGR
SWGSLYGADY
//
