UniProt: A0A077AXJ7

Database: UniProt
Entry: A0A077AXJ7_9PROT

LinkDB:  A0A077AXJ7_9PROT 
Original site:  A0A077AXJ7_9PROT

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Ontology (3)   
   GO (3)   
Gene (1)   
   KEGG GENES (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (13)   
   InterPro (7)   
   Pfam (3)   
   PROSITE (1)   
   SMART (2)   
All databases (19)   

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ID   A0A077AXJ7_9PROT        Unreviewed;       460 AA.
AC   A0A077AXJ7;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=Magnesium transporter MgtE {ECO:0000256|RuleBase:RU362011};
GN   ORFNames=ID47_05840 {ECO:0000313|EMBL:AIK96358.1};
OS   Candidatus Paracaedibacter acanthamoebae.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Holosporales;
OC   Candidatus Paracaedibacteraceae; Paracaedibacter.
OX   NCBI_TaxID=91604 {ECO:0000313|EMBL:AIK96358.1, ECO:0000313|Proteomes:UP000028926};
RN   [1] {ECO:0000313|EMBL:AIK96358.1, ECO:0000313|Proteomes:UP000028926}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PRA3 {ECO:0000313|EMBL:AIK96358.1};
RA   Wang Z., Wu M.;
RT   "Comparative genomic insights into amoeba endosymbionts belonging to the
RT   families of Holosporaceae and Candidatus Midichloriaceae within
RT   Rickettsiales.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a magnesium transporter.
CC       {ECO:0000256|RuleBase:RU362011}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU362011}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362011};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU362011}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SLC41A transporter family.
CC       {ECO:0000256|ARBA:ARBA00009749, ECO:0000256|RuleBase:RU362011}.
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DR   EMBL; CP008941; AIK96358.1; -; Genomic_DNA.
DR   RefSeq; WP_038464698.1; NZ_CP008941.1.
DR   AlphaFoldDB; A0A077AXJ7; -.
DR   KEGG; paca:ID47_05840; -.
DR   eggNOG; COG2239; Bacteria.
DR   HOGENOM; CLU_037408_1_0_5; -.
DR   OrthoDB; 9790355at2; -.
DR   Proteomes; UP000028926; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd04606; CBS_pair_Mg_transporter; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   Gene3D; 1.25.60.10; MgtE N-terminal domain-like; 1.
DR   Gene3D; 1.10.357.20; SLC41 divalent cation transporters, integral membrane domain; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR006668; Mg_transptr_MgtE_intracell_dom.
DR   InterPro; IPR038076; MgtE_N_sf.
DR   InterPro; IPR006669; MgtE_transporter.
DR   InterPro; IPR006667; SLC41_membr_dom.
DR   InterPro; IPR036739; SLC41_membr_dom_sf.
DR   NCBIfam; TIGR00400; mgtE; 1.
DR   PANTHER; PTHR43773; MAGNESIUM TRANSPORTER MGTE; 1.
DR   PANTHER; PTHR43773:SF1; MAGNESIUM TRANSPORTER MGTE; 1.
DR   Pfam; PF00571; CBS; 1.
DR   Pfam; PF01769; MgtE; 1.
DR   Pfam; PF03448; MgtE_N; 1.
DR   SMART; SM00116; CBS; 1.
DR   SMART; SM00924; MgtE_N; 1.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF161093; MgtE membrane domain-like; 1.
DR   SUPFAM; SSF158791; MgtE N-terminal domain-like; 1.
DR   PROSITE; PS51371; CBS; 1.
PE   3: Inferred from homology;
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW   Cell membrane {ECO:0000256|RuleBase:RU362011};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU362011};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362011};
KW   Metal-binding {ECO:0000256|RuleBase:RU362011};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028926};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362011};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362011};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362011}.
FT   TRANSMEM        297..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   TRANSMEM        323..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   TRANSMEM        371..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   TRANSMEM        398..424
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   TRANSMEM        436..459
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362011"
FT   DOMAIN          215..273
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
SQ   SEQUENCE   460 AA;  50981 MW;  E222F370A82C3BDC CRC64;
     MDEKNLDPTL HQEPAEQELD LAHLVESAFD AEMLDEVFSL TSNLHPADMA DIIQQFPAQK
     RLRLVELLHT TISGEALSFL EESVREQILP LFTTAEVAAA IHELESDDAA LILEDLDEDM
     QREVLDALPL EERISFEKTR SYPEYSAGRL MQREVVLCCP HWSLGQIIDS LEDIEHLPEH
     FYDVYVVDDD NKPIGEIPLS WILRHPRRTP VAKVMNPEVR SVPVNLDQEE VAYIFQRYSL
     SSMPVVDQDG RIAGMITVDD IINVIQEEAG DDILKLGGVT QETSLYGNII QASLSRFGWL
     FISLINCLIA SFVIAHFEQA LESFVVLAFL MPIVASMGGN AGMQTLTITV RSLSIYNLRA
     GHVVSAIKRE LSIAALNGLA LALILSSITL LWTGSLKIGF IIGMALLFNV LWSGFAGAFI
     PYILHRVNLD PAISAGPIMS TTTDVIGFSL FLGLATLILL
//

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