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Database: UniProt
Entry: A0A077C4R6_9PROT
LinkDB: A0A077C4R6_9PROT
Original site: A0A077C4R6_9PROT 
ID   A0A077C4R6_9PROT        Unreviewed;       280 AA.
AC   A0A077C4R6;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   08-MAY-2019, entry version 23.
DE   RecName: Full=2-dehydro-3-deoxyphosphooctonate aldolase {ECO:0000256|HAMAP-Rule:MF_00056};
DE            EC=2.5.1.55 {ECO:0000256|HAMAP-Rule:MF_00056};
DE   AltName: Full=3-deoxy-D-manno-octulosonic acid 8-phosphate synthase {ECO:0000256|HAMAP-Rule:MF_00056};
DE   AltName: Full=KDO-8-phosphate synthase {ECO:0000256|HAMAP-Rule:MF_00056};
DE            Short=KDO 8-P synthase {ECO:0000256|HAMAP-Rule:MF_00056};
DE            Short=KDOPS {ECO:0000256|HAMAP-Rule:MF_00056};
DE   AltName: Full=Phospho-2-dehydro-3-deoxyoctonate aldolase {ECO:0000256|HAMAP-Rule:MF_00056};
GN   Name=kdsA {ECO:0000256|HAMAP-Rule:MF_00056};
GN   ORFNames=IM40_03150 {ECO:0000313|EMBL:AIL12748.1};
OS   Candidatus Paracaedimonas acanthamoebae.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Holosporales;
OC   Caedimonadaceae; Candidatus Paracaedimonas.
OX   NCBI_TaxID=244581 {ECO:0000313|EMBL:AIL12748.1};
RN   [1] {ECO:0000313|EMBL:AIL12748.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=30173 {ECO:0000313|EMBL:AIL12748.1};
RA   Wang Z., Wu M.;
RT   "Comparative genomic insights into amoeba endosymbionts belonging to
RT   the families of Holosporaceae and Candidatus Midichloriaceae within
RT   Rickettsiales.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 3-
CC         deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate;
CC         Xref=Rhea:RHEA:14053, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57693, ChEBI:CHEBI:58702, ChEBI:CHEBI:85985;
CC         EC=2.5.1.55; Evidence={ECO:0000256|HAMAP-Rule:MF_00056,
CC         ECO:0000256|SAAS:SAAS01123735};
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide
CC       biosynthesis. {ECO:0000256|SAAS:SAAS00700395}.
CC   -!- PATHWAY: Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate
CC       biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-
CC       phosphate: step 2/3. {ECO:0000256|HAMAP-Rule:MF_00056,
CC       ECO:0000256|SAAS:SAAS00700401}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00056,
CC       ECO:0000256|SAAS:SAAS00700398}.
CC   -!- SIMILARITY: Belongs to the KdsA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00056, ECO:0000256|SAAS:SAAS00700400}.
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DR   EMBL; CP008936; AIL12748.1; -; Genomic_DNA.
DR   STRING; 244581.IM40_03150; -.
DR   EnsemblBacteria; AIL12748; AIL12748; IM40_03150.
DR   KEGG; caq:IM40_03150; -.
DR   KO; K01627; -.
DR   UniPathway; UPA00030; -.
DR   UniPathway; UPA00357; UER00474.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008676; F:3-deoxy-8-phosphooctulonate synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019294; P:keto-3-deoxy-D-manno-octulosonic acid biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00056; KDO8P_synth; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006269; KDO8P_synthase.
DR   PANTHER; PTHR21057; PTHR21057; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   TIGRFAMs; TIGR01362; KDO8P_synth; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00056,
KW   ECO:0000256|SAAS:SAAS00700397};
KW   Lipopolysaccharide biosynthesis {ECO:0000256|HAMAP-Rule:MF_00056,
KW   ECO:0000256|SAAS:SAAS00700406};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00056,
KW   ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN        8    270       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   280 AA;  30120 MW;  30C0B5296717037E CRC64;
     MTIGTKDVKQ VTFGNDLPLA VFAGPCVLES RAHGLEMSAA IREISDMLNI PIVYKTSFDK
     ANRSSNKNAR GLGLEKALPI LAEIREKSGL AVITDVHTAE QCAIVAEVVD VLQIPAFLCR
     QTDLLEAAAI TGKPIHVKKG QFLAPWDMKN VVAKFESFGN TQVLLCERGV SFGYNTLVSD
     MRSLPVLKDT GYPVVFDATH SVQQPGGQGT SSGGQREFVP VLARAAVSVG VAGVFLETHQ
     DPDQAPSDGP NMVYLKDLPN LLKTLMQFDQ LSKSLLPLSA
//
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