ID A0A077DFS7_9BURK Unreviewed; 866 AA.
AC A0A077DFS7;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=aconitate hydratase {ECO:0000256|ARBA:ARBA00012926};
DE EC=4.2.1.3 {ECO:0000256|ARBA:ARBA00012926};
GN ORFNames=IX83_00605 {ECO:0000313|EMBL:AIL32023.1};
OS Basilea psittacipulmonis DSM 24701.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Alcaligenaceae; Basilea.
OX NCBI_TaxID=1072685 {ECO:0000313|EMBL:AIL32023.1, ECO:0000313|Proteomes:UP000028945};
RN [1] {ECO:0000313|EMBL:AIL32023.1, ECO:0000313|Proteomes:UP000028945}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 24701 {ECO:0000313|EMBL:AIL32023.1,
RC ECO:0000313|Proteomes:UP000028945};
RX PubMed=24581117; DOI=10.1186/1471-2164-15-169;
RA Whiteson K.L., Hernandez D., Lazarevic V., Gaia N., Farinelli L.,
RA Francois P., Pilo P., Frey J., Schrenzel J.;
RT "A genomic perspective on a new bacterial genus and species from the
RT Alcaligenaceae family, Basilea psittacipulmonis.";
RL BMC Genomics 15:169-169(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=citrate = D-threo-isocitrate; Xref=Rhea:RHEA:10336,
CC ChEBI:CHEBI:15562, ChEBI:CHEBI:16947; EC=4.2.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00023501};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SIMILARITY: Belongs to the aconitase/IPM isomerase family.
CC {ECO:0000256|ARBA:ARBA00007185}.
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DR EMBL; CP009238; AIL32023.1; -; Genomic_DNA.
DR RefSeq; WP_038497958.1; NZ_CP009238.1.
DR AlphaFoldDB; A0A077DFS7; -.
DR STRING; 1072685.IX83_00605; -.
DR KEGG; bpsi:IX83_00605; -.
DR eggNOG; COG1048; Bacteria.
DR HOGENOM; CLU_013476_2_1_4; -.
DR OrthoDB; 9764318at2; -.
DR Proteomes; UP000028945; Chromosome.
DR GO; GO:0003994; F:aconitate hydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019679; P:propionate metabolic process, methylcitrate cycle; IEA:InterPro.
DR Gene3D; 6.10.190.10; -; 1.
DR Gene3D; 3.30.499.10; Aconitase, domain 3; 2.
DR Gene3D; 3.20.19.10; Aconitase, domain 4; 1.
DR InterPro; IPR012708; 2Me_IsoCit_deHydtase_FeS-dep.
DR InterPro; IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
DR InterPro; IPR001030; Acoase/IPM_deHydtase_lsu_aba.
DR InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR InterPro; IPR006249; Aconitase/IRP2.
DR InterPro; IPR036008; Aconitase_4Fe-4S_dom.
DR InterPro; IPR000573; AconitaseA/IPMdHydase_ssu_swvl.
DR NCBIfam; TIGR02333; 2met_isocit_dHY; 1.
DR PANTHER; PTHR11670:SF43; 2-METHYLCITRATE DEHYDRATASE (2-METHYL-TRANS-ACONITATE FORMING); 1.
DR PANTHER; PTHR11670; ACONITASE/IRON-RESPONSIVE ELEMENT FAMILY MEMBER; 1.
DR Pfam; PF00330; Aconitase; 1.
DR Pfam; PF00694; Aconitase_C; 1.
DR PRINTS; PR00415; ACONITASE.
DR SUPFAM; SSF53732; Aconitase iron-sulfur domain; 1.
DR SUPFAM; SSF52016; LeuD/IlvD-like; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000028945}.
FT DOMAIN 60..536
FT /note="Aconitase/3-isopropylmalate dehydratase large
FT subunit alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF00330"
FT DOMAIN 659..791
FT /note="Aconitase A/isopropylmalate dehydratase small
FT subunit swivel"
FT /evidence="ECO:0000259|Pfam:PF00694"
SQ SEQUENCE 866 AA; 95768 MW; C3F9304D8EB33EB5 CRC64;
MMSNRQLLPQ SHRYYYDAKK LCDEIKPNAY EQLPYTCKIL AENIVRKAEG RYEEDQINTW
LNELIEHKKE IDFPWYPARV VCHDILGQTA LVDLAGLRDA IAEKGGDPSK VNPVVQTQLI
VDHSLAVEYG GDDPDAFEKN RSIEDRRNED RFHFINWTKT AFENVDVIPA GNGIMHQINL
EKMSPVIQVN GDTAFPDSCV GTDSHTPHTD ALGVISIGVG GLEAETVMLG RACMMRVPDI
IGIHLTGKRQ PGITATDIVL ALTEFLRKEK VVGAFLEFFG EGADSLTIGD RATISNMTPE
YGATAALFYI DQQTLDYLTL TGRDPQQVAL VKEYAQATGL WSEMMKTAVY PRTLSFDLSK
VERNIAGPSH PHARLSTRDL KTKGIAKPHT QINNEIPDGA VIIAAITSCT NTSNPRNVIA
AGLLARNANR RGLTRKPWVK SSFAPGSKVA EMYLNEAGLL KEMETLGFGV VAFACTTCNG
MSGALDPAIQ KEIIERDVYT TAVLSGNRNF DGRIHPYAKQ AFLASPPLVI AYAIAGNIHV
DIEQDSLGQD KNGSDVYLKD IWPDDHEIDE IVKTFVKPQQ FNAVYTPMFA SKTINKTTHP
LYDWKKDSTY ISRPPYWNSE LSQPRSLKGM RPLAILPDNI TTDHLSPSNA ILPNSAAGEY
LSKMGLAEED FNSYATHRGD HHTAQRATLA NPKLFNEMVK DEHGQTIQGS LTRIEPEGKI
SRIWEAIETY QSRQQPLIII AGADYGQGSS RDWAAKGVRL AGVQAIVAEG FERIHRSNLV
GMGILPLQFE AGTNRHTLKL DGTELYDVIG TPQAKGSLTL KITRQNGQID LIPVHCCLNT
DEETLVYEAG GVLPRFAQDF LATHSK
//
