ID A0A077EF62_9FLAO Unreviewed; 1043 AA.
AC A0A077EF62;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=BD94_0355 {ECO:0000313|EMBL:AIL44130.1};
OS Elizabethkingia anophelis NUHP1.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC Elizabethkingia.
OX NCBI_TaxID=1338011 {ECO:0000313|EMBL:AIL44130.1, ECO:0000313|Proteomes:UP000028933};
RN [1] {ECO:0000313|EMBL:AIL44130.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NUHP1 {ECO:0000313|EMBL:AIL44130.1};
RX PubMed=24012265; DOI=10.1016/S0140-6736(13)61858-9;
RA Teo J., Tan S.Y., Tay M., Ding Y., Kjelleberg S., Givskov M., Lin R.T.,
RA Yang L.;
RT "First case of E anophelis outbreak in an intensive-care unit.";
RL Lancet 382:855-856(2013).
RN [2] {ECO:0000313|EMBL:AIL44130.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NUHP1 {ECO:0000313|EMBL:AIL44130.1};
RX PubMed=26019164; DOI=10.1093/gbe/evv101;
RA Li Y., Liu Y., Chew S.C., Tay M., Salido M.M., Teo J., Lauro F.M.,
RA Givskov M., Yang L.;
RT "Complete Genome Sequence and Transcriptomic Analysis of the Novel Pathogen
RT Elizabethkingia anophelis in Response to Oxidative Stress.";
RL Genome Biol. Evol. 7:1676-1685(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; CP007547; AIL44130.1; -; Genomic_DNA.
DR RefSeq; WP_009085642.1; NZ_CP007547.1.
DR AlphaFoldDB; A0A077EF62; -.
DR STRING; 1338011.BD94_0355; -.
DR GeneID; 56685457; -.
DR KEGG; eao:BD94_0355; -.
DR eggNOG; COG1074; Bacteria.
DR HOGENOM; CLU_010638_0_0_10; -.
DR Proteomes; UP000028933; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 1.10.3170.10; Recbcd, chain B, domain 2; 1.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF64; ATP-DEPENDENT DNA HELICASE REP; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 1..468
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 469..743
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT COILED 212..239
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 9..16
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1043 AA; 121563 MW; 69A6ED163A35221D CRC64;
MNTYTVINAS AGSGKTYSLI KNLLKICLRN NRPEIIRNIL ALTFTNKAAN EMKERILSWL
GDFTSDHYMN IQALTDIQKE LKGEGIHLTL EDLHYRSKNL LDYILHHYSA LNISTIDKFN
TRLIRSFAYE LGLPQNFNLE INAAPFLLEA VDQTLDKIGD NEQLSVAFMD YVNYNLDNQK
RENLQKTLFD SAKNFNSDIH YFTLGKNKNF DWNAYSDEKE KIRKEIKQLM KEAKEKALSS
VELIKSRDLS IEDFAGGKVN SIAVFFEKYL NTESPALPTN SEEKALENYN KLSGAKSKNR
ADEIAAILPI LLDNRKNIIL NHLEIEKKKK IHTALLPLKV NKEIQDQLKF IEDENDLLML
SRFNVLINEQ LRNEPSAFIY EKVGEQYQHY FFDEFQDTSF LQWQNFLPLR DHILSEESTS
FTLVGDPKQS IYRFRGGDAQ LMLDIINKKE ETPRYADIHN LEHNYRSSYN IVEFNNKLYD
YLSDFVEEDY RDIFGTLAQQ KPHSENAGRV KINLVENNSV DVFFDEVAEK MKNDIQECLD
NGFSFSDIAI LCRGNNDILK FSQSLSALEV DYKNEKQFIR TISEKGLTLD LSATINAVIQ
YLLWYSFPKN RRYLVLCLYY LNKSGRISIE DFSAELSDIL LAENTTSLQQ KVEEKYKLKL
TSDIPNLNTY SFIESILQEF SVKGKETDYL INFLELLYGF FQNMAATLKD FLQYWQEEGH
SISIQASENT DAINLMTIHK SKGLEFPVVF LPMRNSHKDT QFNDWYDISD SREQPLQTVN
LTSFNKDLAQ YDQSMTSFNE VNTYKNKIDR FCIQYVATTR AVEQMFFYIQ KPGKTSGYLE
IYDFIAGQKS IDEDSFDFFE TDEKHLLKQR KKTKQHTGQD LHIGSLRASD ETFSTEIKIA
TPSKSYQERN ESVKTGIFTH QILEKVVTKE DAPYVLKQYL LDGTITKSEF EAVQIRLNKL
FETYPQYFDG HYEVINERDM LFSDKGESRL LRTDRLLKAP EGWIIIDFKT GAEREKYEDQ
IDIYKKALER SGEKVWKTEV LYI
//
