ID A0A077EFJ4_9FLAO Unreviewed; 1051 AA.
AC A0A077EFJ4;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Cobalt-zinc-cadmium resistance protein CzcA {ECO:0000313|EMBL:AIL44295.1};
GN ORFNames=BD94_0520 {ECO:0000313|EMBL:AIL44295.1};
OS Elizabethkingia anophelis NUHP1.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC Elizabethkingia.
OX NCBI_TaxID=1338011 {ECO:0000313|EMBL:AIL44295.1, ECO:0000313|Proteomes:UP000028933};
RN [1] {ECO:0000313|EMBL:AIL44295.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NUHP1 {ECO:0000313|EMBL:AIL44295.1};
RX PubMed=24012265; DOI=10.1016/S0140-6736(13)61858-9;
RA Teo J., Tan S.Y., Tay M., Ding Y., Kjelleberg S., Givskov M., Lin R.T.,
RA Yang L.;
RT "First case of E anophelis outbreak in an intensive-care unit.";
RL Lancet 382:855-856(2013).
RN [2] {ECO:0000313|EMBL:AIL44295.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NUHP1 {ECO:0000313|EMBL:AIL44295.1};
RX PubMed=26019164; DOI=10.1093/gbe/evv101;
RA Li Y., Liu Y., Chew S.C., Tay M., Salido M.M., Teo J., Lauro F.M.,
RA Givskov M., Yang L.;
RT "Complete Genome Sequence and Transcriptomic Analysis of the Novel Pathogen
RT Elizabethkingia anophelis in Response to Oxidative Stress.";
RL Genome Biol. Evol. 7:1676-1685(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP007547; AIL44295.1; -; Genomic_DNA.
DR RefSeq; WP_024564653.1; NZ_CP007547.1.
DR AlphaFoldDB; A0A077EFJ4; -.
DR STRING; 1338011.BD94_0520; -.
DR KEGG; eao:BD94_0520; -.
DR eggNOG; COG3696; Bacteria.
DR HOGENOM; CLU_002755_1_2_10; -.
DR Proteomes; UP000028933; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004763; CusA-like.
DR NCBIfam; TIGR00914; 2A0601; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF24; CATION EFFLUX SYSTEM (ACRB_ACRD_ACRF FAMILY); 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 483..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 541..560
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 878..897
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 904..923
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 929..955
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 976..995
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1007..1033
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1051 AA; 115413 MW; 87D9C06B97346692 CRC64;
MLNKIIEFSI KNKLIIGLMT LALVIYGVIE LRKLPIDAVP DITDNQVQII TASPSLGAPD
VERFITFPIE QVSRNIVGVK QIRSFSRFGL SVITIVFNED TNVYLARQQV AERLQQVSQD
IPKEIGVPAM APITTGLGEI YQYVVRPKKG YEHRYSAMEL RTIQDWIVRR QLLGVEGVAD
VASFGGDLKQ YEIAIKPAQL KAVGVTMQQL FTAVENNNQN AGGAYIEKGP NALFIRTEGL
AKNISDIENI VVKNLPDGTP ILVKNIAEVK LGKAIKYGAM TYNGKGEVAG AVVMMMKGGN
SNQVIDKIKT RVEEIQKTLP EGVKIEAFLD RTKMVDNAIG TVSKNLIEGA LIVVFVLVLF
LGNFRAGFIV ASVIPLAMLF AIIMMNIFGV SGNLMSLGAL DFGLIVDGAV IIVEAVLHRL
HSIKGKEGER ISSEQMNKEV KTSAGKMMNS AVFGQVIILI VYLPILSLQG IEGKMFKPMA
QTVAFALIGA FILSLTYIPM MSSVFLSRKI QTKPTFSDRM IEKLVAFYDR SLAKVLKSSK
IVMTVVFLLF ALAVFILSKL GGEFIPSLPE GDFAVETRIL PGSSLKTSTE VVLKSQQVLM
SKFPEIKKIV GKTGSSEIPT DPMPLDASDM MIILKDRKEW TSADNYNDLA DKMQKELQKN
MVGVTYSFQY PVAMRFNELM TGARQDVVCK IFGENLDTLK VYSEKLAAVV NKVNGAQNIY
VEPVSGLSQI VINYNRSALA QYGLNVSDVN NVVNAAFAGK VTGAVFEGEK KFDMVVRMDS
EERKKLEDVQ NLLLTTSSGT DIPLKSVADV DIKESVNQIQ RENAARRIIV GFNVRNRDIQ
STVNDLQNRV NSELKLPAGY SITYGGNFEN LQEAKARLGI AVPVSLLLIL LMLYFAFRSV
KYGLIIFTAI PLSAVGGVFA LWLRGMDFSI SAGIGFIALF GVAVLNGIVL IAEFNRQKTQ
KEDLRDVVLT GGKNRLRPVL MTATVASLGF LPMALSNGEG AEVQRPLATV VIGGLMLATF
LTLYVLPILY IFFEKKSFNK TKTVSETEHK I
//
