ID A0A077EL96_9FLAO Unreviewed; 377 AA.
AC A0A077EL96;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Membrane fusion component of tripartite multidrug resistance system {ECO:0000313|EMBL:AIL46210.1};
GN ORFNames=BD94_2435 {ECO:0000313|EMBL:AIL46210.1};
OS Elizabethkingia anophelis NUHP1.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC Elizabethkingia.
OX NCBI_TaxID=1338011 {ECO:0000313|EMBL:AIL46210.1, ECO:0000313|Proteomes:UP000028933};
RN [1] {ECO:0000313|EMBL:AIL46210.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NUHP1 {ECO:0000313|EMBL:AIL46210.1};
RX PubMed=24012265; DOI=10.1016/S0140-6736(13)61858-9;
RA Teo J., Tan S.Y., Tay M., Ding Y., Kjelleberg S., Givskov M., Lin R.T.,
RA Yang L.;
RT "First case of E anophelis outbreak in an intensive-care unit.";
RL Lancet 382:855-856(2013).
RN [2] {ECO:0000313|EMBL:AIL46210.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NUHP1 {ECO:0000313|EMBL:AIL46210.1};
RX PubMed=26019164; DOI=10.1093/gbe/evv101;
RA Li Y., Liu Y., Chew S.C., Tay M., Salido M.M., Teo J., Lauro F.M.,
RA Givskov M., Yang L.;
RT "Complete Genome Sequence and Transcriptomic Analysis of the Novel Pathogen
RT Elizabethkingia anophelis in Response to Oxidative Stress.";
RL Genome Biol. Evol. 7:1676-1685(2015).
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; CP007547; AIL46210.1; -; Genomic_DNA.
DR RefSeq; WP_024564068.1; NZ_CP007547.1.
DR AlphaFoldDB; A0A077EL96; -.
DR STRING; 1338011.BD94_2435; -.
DR KEGG; eao:BD94_2435; -.
DR eggNOG; COG1566; Bacteria.
DR HOGENOM; CLU_018816_15_1_10; -.
DR Proteomes; UP000028933; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR032317; HlyD_D23.
DR PANTHER; PTHR30386; MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP; 1.
DR PANTHER; PTHR30386:SF26; TRANSPORT PROTEIN COMB; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 2.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022519};
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 41..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 80..322
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 148..206
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 377 AA; 41925 MW; F91297A5BF94E787 CRC64;
MESKDNVQQE QPTQGTATKV QMSTRVEEKK KANKKNKIRS TIANSIVFII LIAGFYWLVR
EYFHIGDKDY TEAAQVEEFI NPVNTRVAGY IKEIKFIEHQ QVKKGDTLLI LDDREIQTQL
GQAEAAYQNA LAQRSATSSS VNTVSNNVNV MESNIAGAKA RLWNAEQNLN RYKNLLAAEA
VTRQQYDQIK TEYDAQKAAY ETLVNQKQSA NLSTTEVKSK LGINDAEIKR TKAALDMAKL
NLSYTIITAP YDGVMGRRVI SDGQLVQAGQ QIATIVLNGQ KWVTANFLES QMPKIAIGKK
IMMSADALGG QQFEGEVTAI SAATGSRYSS VPTDNSTGNF IKVQQRIPVR IEFTSGNDKQ
KLNQLRAGMN MIIKLKD
//
