ID A0A077F343_9PSED Unreviewed; 265 AA.
AC A0A077F343;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase {ECO:0000313|EMBL:AIL59902.1};
DE SubName: Full=Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase {ECO:0000313|EMBL:QGW75850.1};
GN ORFNames=GPJ81_03855 {ECO:0000313|EMBL:QGW75850.1}, PSAKL28_06680
GN {ECO:0000313|EMBL:AIL59902.1};
OS Pseudomonas alkylphenolica.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=237609 {ECO:0000313|EMBL:AIL59902.1, ECO:0000313|Proteomes:UP000028931};
RN [1] {ECO:0000313|EMBL:AIL59902.1, ECO:0000313|Proteomes:UP000028931}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KL28 {ECO:0000313|EMBL:AIL59902.1,
RC ECO:0000313|Proteomes:UP000028931};
RA Lee K., Lim J.Y., Hwang I.;
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:QGW75850.1, ECO:0000313|Proteomes:UP000426235}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Neo {ECO:0000313|EMBL:QGW75850.1,
RC ECO:0000313|Proteomes:UP000426235};
RA Ne Ville C.J., Enright D., Hernandez I., Dodsworth J., Orwin P.M.;
RT "Hybrid Genome Assemblies of two High G+C Isolates from Undergraduate
RT Microbiology Courses.";
RL Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-
CC amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP;
CC Xref=Rhea:RHEA:19893, ChEBI:CHEBI:30616, ChEBI:CHEBI:57841,
CC ChEBI:CHEBI:58354, ChEBI:CHEBI:456216; EC=2.7.4.7;
CC Evidence={ECO:0000256|ARBA:ARBA00000565};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-
CC methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+);
CC Xref=Rhea:RHEA:23096, ChEBI:CHEBI:15378, ChEBI:CHEBI:16892,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58354, ChEBI:CHEBI:456216;
CC EC=2.7.1.49; Evidence={ECO:0000256|ARBA:ARBA00000151};
CC -!- PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004948}.
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DR EMBL; CP009048; AIL59902.1; -; Genomic_DNA.
DR EMBL; CP046621; QGW75850.1; -; Genomic_DNA.
DR RefSeq; WP_038606609.1; NZ_CP046621.1.
DR AlphaFoldDB; A0A077F343; -.
DR KEGG; palk:PSAKL28_06680; -.
DR eggNOG; COG0351; Bacteria.
DR HOGENOM; CLU_020520_0_2_6; -.
DR OrthoDB; 9810880at2; -.
DR UniPathway; UPA00060; UER00138.
DR Proteomes; UP000028931; Chromosome.
DR Proteomes; UP000426235; Chromosome.
DR GO; GO:0008972; F:phosphomethylpyrimidine kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR GO; GO:0009229; P:thiamine diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd01169; HMPP_kinase; 1.
DR Gene3D; 3.40.1190.20; -; 1.
DR InterPro; IPR004399; HMP/HMP-P_kinase_dom.
DR InterPro; IPR013749; PM/HMP-P_kinase-1.
DR InterPro; IPR029056; Ribokinase-like.
DR PANTHER; PTHR20858:SF17; HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED; 1.
DR PANTHER; PTHR20858; PHOSPHOMETHYLPYRIMIDINE KINASE; 1.
DR Pfam; PF08543; Phos_pyr_kin; 1.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:AIL59902.1};
KW Transferase {ECO:0000313|EMBL:AIL59902.1}.
FT DOMAIN 17..253
FT /note="Pyridoxamine kinase/Phosphomethylpyrimidine kinase"
FT /evidence="ECO:0000259|Pfam:PF08543"
SQ SEQUENCE 265 AA; 28426 MW; C607663E15E9928B CRC64;
MNTYSSRPVV LCLSGHDPSG GAGLQADIEA LIAQGCHAAP AVTALTVQDT VNVTDFRVLD
REWVLAQANA VLADSTVAAV KLGMLGSLDM VDTVVELLSA HPHLPLVCDP VLRAGGGGRL
GKDEVGYAMR ERLLPLATIA TPNLPEARIL AELPEGTADE CAEKLLPFVR HLLITGGHGD
EHEIHNRLYS RDGQRHTWTC QRLPGSYHGS GCTLASALAG RLALGEQLQS AVRSALDYTW
RTLRDAEQLG KGQYVPRRLP LDFCS
//
