ID A0A077FD33_9PSED Unreviewed; 336 AA.
AC A0A077FD33;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Pyruvate dehydrogenase, E1 component subunit alpha {ECO:0000313|EMBL:AIL61759.1};
GN ORFNames=PSAKL28_25610 {ECO:0000313|EMBL:AIL61759.1};
OS Pseudomonas alkylphenolica.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=237609 {ECO:0000313|EMBL:AIL61759.1, ECO:0000313|Proteomes:UP000028931};
RN [1] {ECO:0000313|EMBL:AIL61759.1, ECO:0000313|Proteomes:UP000028931}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KL28 {ECO:0000313|EMBL:AIL61759.1,
RC ECO:0000313|Proteomes:UP000028931};
RA Lee K., Lim J.Y., Hwang I.;
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR EMBL; CP009048; AIL61759.1; -; Genomic_DNA.
DR RefSeq; WP_038610920.1; NZ_CP009048.1.
DR AlphaFoldDB; A0A077FD33; -.
DR KEGG; palk:PSAKL28_25610; -.
DR eggNOG; COG1071; Bacteria.
DR HOGENOM; CLU_029393_5_0_6; -.
DR OrthoDB; 9766715at2; -.
DR Proteomes; UP000028931; Chromosome.
DR GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR029061; THDP-binding.
DR PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Pyruvate {ECO:0000313|EMBL:AIL61759.1}.
FT DOMAIN 47..325
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
SQ SEQUENCE 336 AA; 36263 MW; 2A8EF11136CAE886 CRC64;
MQATHEQLLW MYHRMLLIRE YEDTLAMVYF EGKLPPHIQK GLAFDIGAGT IPGEMHLSAG
QEAAATGVCV HLEKQDSVWG THRAHHFAIA KGVPLDRMTA EIFGKVDGLC RGKGGHMHLY
DTEHNFACNG IVGAGIPHAC GAGLAARLKG NGAVAIAEFG DGAANQGSFH ESLNLASLWK
LPVVFVCQDN NYGISVSKQA STAVESNVER AAGYGMPGIR VAENDAQAMF AAAGEAIARA
RRGEGPTLIE MKVDRYYGHF QGDPEGYRPK GEVRALKQHD PIVKLEKQLL ELGVLDDAQV
QSAREATSQQ VRAAIAFARN SAYPDAAEAH LHLFAE
//
